91猫先生

吴明道（Albert M. Wu）

职称：教授

研究室：醣类免疫化学研究室

最高学歷：Ph.D

学校/国家：纽约医学院/美国

分机号码：5175

电子邮件帐号：amwu@mail.cgu.edu.tw

请简述研究方向及研究室特色：

? 研究复杂性碳水化合物的抗原决定因子和生物活性区的化学构造及结合性质，将有助於暸解这些碳水化合物的分子在生物学和医学上所扮演的角色。这些知识对於疫苗的製造和血清诊断(Serodiagnosis)的改进或对於Cancer和Genetic disorders的诊断是有相当的助意的。同时，对於人类血型间的关係，微生物如何附着在宿主细胞和宿主如何在防止微生物侵入的过程，Glycoconjugates在Neurobiology所扮演的角色等等，将能用分子观点来解释，进而可供发展防止感染和中毒的方法。又如Lectins, Chitin和Oligosaccharides等，在医学上、工业上的应用具有相当的潜在力。目前台湾在这方面的基础研究几乎还在起点，长庚医学院的碳水化合物免疫化学研究室拥有抗原製备室、现代化的抗原决定因子纯化系统和免疫化学分析设备，可供国际水準复杂性碳水化合物和分子免疫学的研究。

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Research Description

??? Knowledge of the structures and binding properties of antigenic determinants and active sites (epitopes) of complex carbohydrates will contribute to a better understanding of the functional roles of these carbohydrates at the molecular level, and will provide us with valuable information about the following aspects: (a) understanding life process, mechanism of infections, inflammation, genetic disorders and cancer; (b) producing new reagents to detect cancer; (c) for developing vaccines and drugs to prevent infection, and (d) for improving serodiagnosis.

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最近五年所发表论文：

(1)?? Wu : 复杂性碳水化合物在生物医学上的重要性. Chemistry (The Chinese Chem. Soc., Taiwan), Vol.52, No.4, 462-476, Dec., 1994;

(2)?? Wu (ed): “The Molecular Immunology of Complex Carbohydrates.” Adv. Exp. Med. & Biol. 228, (868 pages). Plenum Press, New York and London, 1988. (长庚医院图书馆有存放);

(3) Defining the Carbohydrate Specificities of Abrus precatorius agglutinin as T (Galb1?3GalNAc) > I/II (Gal b1?3/4GlcNAc). J. Biol. Chem., 267: 19130-19139, 1992;

(4) The Biotin/Avidin-Mediated Microtiter Plate Lectin Assay with the Use of Chemically Modified Glycoprotein Ligand. Analytical Biochem., 221: 266-272, 1994;

(5) A Sheep Hydatid Cyst Glycoprotein as Receptors for three Toxic Lectins, as well as Abrus Precatorius and Ricinus Communis Agglutinins. Biochim. Biophys. Acta., 1243: 124-128, 1995.

(6) 浅谈Gal 和GalNAc有特异性的应用凝集素(Applied lectins)对醣类结合性质的表达和分类. 生命科学简讯, 第十二卷,第一期, P.6, 1998.

(7) Studies on the binding of wheat germ agglutinin (Triticum vulgaris) to O-glycans. FEBS Letter, 440:315-319, 1998. (10) Further characterization of the combining sites of Bandeiraea (Griffonia) simplicifolia lectin-I, isolectin A₄ (GSI-A₄). Glycobiology, in press, 1999.

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