91猫先生

中文姓名：林光辉

职称：特聘教授

研究室名称：基因调控

最高学歷：Ph.D.

学校/国家：阿拉巴马大学/美国

分机号码：88632118800 ext.5975

电子邮件帐号：khlin@mail.cgu.edu.tw

个人网页网址：http://lncrna103.wixsite.com/cgu-lkh

研究室现有： 博士后研究员  2 人

博士班研究生  0  人

硕士班研究生 0 人

专任研究助理  1  人

大学部专题生   0  人

Update：2022/12/26

研究方向及研究室特色：  

甲状腺素在肝臟之异常调控导致肝臟病变产生肝癌之机制。

A.   甲状腺素受体可调控下游基因表现，包括miRNAs, long non-coding (Lnc)RNAs影响细胞的生长、分化和发育之机制。利用之工具:

1.     基因体  microarray; 2.蛋白质体。

B.    肿瘤标识找寻: 利用基因体和蛋白質體技術系統性分析胃癌、子宮頸癌或皮膚癌中表現異常之基因(含small RNAs, LncRNA)，及biomarkers的找寻。

C.   甲狀腺素受體調控自噬机制。

E.  LncRNAs在肝癌中之角色及调控。

.

叁、近五年内获奖情形及重要会议邀请演讲

1.科技部杰出研究奖 (2017)
2.长庚大学特聘教授 (2015-迄今)
3.长庚大学優良教师研究獎 (2005、2012、2017、2018、2019、2022)
4.肝病防治基金会最佳论文(2013、2015、2017)
5.第28届(2018)王民寧奖--基础医学-杰出贡献奖

2019-2025着作目录 (selected publication,全部是通讯作者, 不包括共同作者之SCI论文)  May 06, 2025 updated

1. Yang-Hsiang Lin, Meng-Han Wu, Chia-Jung Liao, Yu-Tung Lin, Chau-Ting Yeh, and Kwang-Huei Lin Thyroid Hormone Suppresses Cell Growth by Regulating CDK2 and Cyclin E1 Expression via Hepsin Am. J. Cancer Res. 15(4). 2025 (SCI; IF: 3.6, 106/322=32.9%, Oncology)
2. Ya-Hui Huang, Chia-Jung Liao, Meng-Han Wu, Ming-Wei Lai, Yung-Hsin Yeh, Chau-Ting Yeh, Yang-Hsiang Lin, and Kwang-Huei Lin Enhanced Inhibitory Effects of Mianserin in Combination with Sorafenib on Liver Cancer Growth through Targeting the CCR9-AKT Pathway Am. J. Cancer Res. 15(4). 2025 (SCI; IF: 3.6, 106/322=32.9%, Oncology)
3. Yang-Hsiang Lin, Meng-Han Wu, Hsiang Cheng Chi, Cheng-Yi Chen, Po-Shuan Huang, Yi-Wen Wang, Tzu-Kang Lin, Chia-Jung Liao, Ming-Wei Lai, Chau-Ting Yeh, and Kwang-Huei Lin The Novel Role of LOC344887 in the Enhancement of Hepatocellular Carcinoma Progression via Modulation of SHP1-regulated STAT3/HMGA2 Signaling Axis Int. J. Biol. Sci. 20(15), 6281-6296. 2024 (SCI; IF: 8.2, 31/313=9.9%, Biochemistry & Molecular Biology)
4. Hsiang-Cheng Chi, Yang-Hsiang Lin, Yuh-Harn Wu, Cheng-Chih Chang, Cheng-Heng Wu, Chau-Ting Yeh, Ching-Chuan Hsieh, and Kwang-Huei Lin CCL16 is a Pro-tumor Chemokine that Recruits Monocytes and Macrophages to Promote Hepatocellular Carcinoma Progression Am. J. Cancer Res. 14(7), 3600-3613. 2024 (SCI; IF: 3.6, 106/322=32.9%, Oncology)
5. Yang-Hsiang Lin, Chau-Ting Yeh, Cheng-Yi Chen, and Kwang-Huei Lin Pseudogene: Relevant or Irrelevant? Biomed. J. #100790, 2024 (SCI; IF: 4.1, 96/313=30.7%, Biochemistry & Molecular Biology)
6. Chia-Jung Liao, Yang-Hsiang Lin, Huei-Tzu Chien, Yi-Wen Wang, Tzu-Kang Lin, Chau-Ting Yeh, and Kwang-Huei Lin Cytidine Deaminase Enhances Liver Cancer Invasion by Modulating Epithelial-Mesenchymal Transition via NFκB Signaling Biomed. J. #100789, 2024 (SCI; IF: 4.1, 96/313=30.7%, Biochemistry & Molecular Biology)
7. Hsun-Hua Lee, Hao-Yu Chuang, Chau-Ting Yeh, Yi-Min Wang, Hsiang-Cheng Chi, and Kwang-Huei Lin RNASE4 Promotes Malignant Progression and Chemoresistance in Hypoxic Glioblastoma via Activation of AXL/AKT and NF-κB/CIAP2/SURVIVIN Signaling Pathways Am. J. Cancer Res. 14(9), 4320-4336, 2024 (SCI; IF: 3.6, 106/322=32.9%, Oncology)
8. Po-Shuan Huang, Ling-Yu Wang, Yi-Wen Wang, Ming-Ming Tsai, Tzu-Kang Lin, Chia-Jung Liao, Chau-Ting Yeh, and Kwang-Huei Lin Evaluation and Application of Drug Resistance by Biomarkers in the Clinical Treatment of Liver Cancer Cells 12(6), 869. 2023 (SCI; IF: 5.1, 63/205=30.7%, Cell Biology)
9. Yi-Hsin Tseng, Cheng-Chih Chang, and Kwang-Huei Lin Thyroid Hormone Upregulates LAMP2 Expression and Lysosome Activity Biochem. Biophys. Res. Commun. 25, 662, 66-75, 2023 (SCI; IF: 2.5, 216/313=69.0%, Biochemistry & Molecular biology)
10. Ya-Hui Huang, Kwang-Huei Lin(co-1st), Ming-Wei Lai, and Chau-Ting Yeh Mifepristone Inhibits Hepatoma Growth by Enhancing the GR-HSP60-survivin Interaction to Facilitate Survivin Degradation J. of Cancer 14(16), 3066-3077. 2023 (SCI; IF: 3.3, 118/322=36.6 %, Oncology)
11. Hsiang-Wei Huang, Ching-Ying Chen, Ya-Hui Huang, Chau-Ting Yeh, Chia-Siu Wang, Cheng-Chih Chang, and Kwang-Huei Lin CMAHP Promotes Metastasis by Reducing Ubiquitination of Snail and Inducing Angiogenesis via GM-CSF Overexpression in Gastric Cancer Oncogene 41(2),159-172. 2022 (SCI; IF: 6.9, 36/313=11.5%, Biochemistry & Molecular biology)
12. Chia-Jung Liao, Po-Shuan Huang, Hui-Tzu Chien, Tzu-Kang Lin, Chau-Ting Yeh, and Kwang-Huei Lin Effects of Thyroid Hormones on Lipid Metabolism Pathologies in Non-Alcoholic Fatty Liver Disease Biomedicines 10(6), 1232, 1-17, 2022 (SCI; IF: 3.9, 104/313=33.2%, Biochemistry & Molecular biology)
13. Pei Yi Chu, Wei Chieh Huang, Shiao Lin Tung, Chung Ying Tsai, Chih Jung Chen,Yu Chin Liu Chia Wen Lee, Yang Hsiang Lin, Hung Yu Lin, Cheng Yi Chen, Chau Ting Yeh, Kwang-Huei Lin, and Hsiang Cheng Chi IFITM3 Promotes Malignant Progression, Cancer Stemness and Chemoresistance of Gastric Cancer by Targeting MET/AKT/FOXO3/c MYC Axis Cell & Bioscience 12(1), 124, 2022 (SCI; IF: 6.1, 47/313=15.0% Biochemistry & Molecular biology)
14. Yu-Chin Liu, Yang-Hsiang Lin, Hsiang-Cheng Chi, Po-Shuan Huang, Chia-Jung Liao, Yu-Syuan Liou, Chiao-Chun Lin, Chia-Jung Yu, Chau-Ting Yeh, Ya-Hui Huang, and Kwang-Huei Lin CRNDE Acts as an Epigenetic Modulator of the p300/YY1 Complex to Promote HCC Progression and Therapeutic Resistance Clinical Epigenetics 14(1), 106. 2022 (SCI; IF: 4.8, 29/191=15.2% Genetics & Heredity)
15. Yang-Hsiang Lin, Yu-Chin Liu, Cheng-Yi Chen, Hsiang-Cheng Chi, Meng-Han Wu, Po-Shuan Huang, Cheng-Chih Chang, Tzu-Kang Lin, Chau-Ting Yeh, and Kwang-Huei Lin LPAL2 Suppresses Tumor Growth and Metastasis of Hepatocellular Carcinoma by Modulating MMP9 Expression Cells 11(16), 2610. 2022 (SCI; IF: 5.1, 63/205=30.7%, Cell Biology)
16. Po-Shuan Huang, Cheng-Chih Chang, Chia-Siu Wang, and Kwang-Huei Lin Functional Roles of Non-Coding RNAs Regulated by Thyroid Hormones in Liver Cancer Biomed. J. 44(3), 272-284. 2021 (SCI; IF: 4.1, 96/313=30.7%, Biochemistry & Molecular Biology)
17. Hsiang-Wei Huang, Cheng-Chih Chang, Chia-Siu Wang and Kwang-Huei Lin Association between Inflammation and Function of Cell Adhesion Molecules Influence on Gastrointestinal Cancer Development Cells 10(1), 67. 2021 (SCI; IF: 5.1, 63/205=30.7%, Cell Biology)
18. Yang-Hsiang Lin, Meng-Han Wu, Yi-Chung Liu, Ping-Chiang Lyu, Chau-Ting Yeh, and Kwang-Huei Lin LINC01348 Suppresses Hepatocellular Carcinoma Metastasis through Inhibition of SF3B3-mediated EZH2 re-mRNA Splicing Oncogene 40(28), 4675–4685. 2021 (SCI; IF: 6.9, 36/313=11.5%, Biochemistry & Molecular biology)
19. Po-Shuan Huang, Chia-Jung Liao, Ya-Hui Huang, Chau-Ting Yeh, Cheng Yi Chen, Hui-Chi Tang, Cheng-Chih Chang, and Kwang-Huei Lin Functional and Clinical Significance of Dysregulated MicroRNAs in Liver Cancer Cancers 13(21), 5361, 2021 (SCI; IF: 4.5, 78/322=24.2 %, Oncology)
20. Yang-Hsiang Lin, Meng-Han Wu, Ya-Hui Huang, Chau-Ting Yeh, and Kwang-Huei Lin TUG1 is a Regulator of AFP and Serves as Prognostic Marker in Non-hepatitis B Non-hepatitis C Hepatocellular Carcinoma Cells 9(2), 262. 2020 (SCI; IF: 5.1, 63/205=30.7 %, Cell Biology)
21. Po-Shuan Huang, Yang-Hsiang Lin, Hsiang-Cheng Chi, Yi-Hsin Tseng, Cheng Yi Chen, Tzu-Kang Lin, Chau-Ting Yeh, and Kwang-Huei Lin Dysregulated FAM215A Stimulates LAMP2 Expression to Confer Drug-Resistant and Malignant in Human Liver Cancer Cells 9(4), 961. 2020 (SCI; IF: 5.1, 63/205=30.7 %, Cell Biology)
22. Syuan-Ling Lin, Yang-Hsiang Lin, Hsiang-Cheng Chi, Tzu-Kang Lin, Wei-Jan Chen, Chau-Ting Yeh and Kwang-Huei Lin A Novel Long Non-Coding RNA-01488 Suppressed Metastasis and Tumorigenesis by Inducing miRNAs That Reduce Vimentin Expression and Ubiquitination of Cyclin E Cells 9(6), 1504. 2020 (SCI; IF: 5.1, 63/205=30.7 %, Cell Biology)
23. Yu-Chin Liu, Chau-Ting Yeh, and Kwang-Huei Lin Cancer Stem Cell Functions in Hepatocellular Carcinoma and Comprehensive Therapeutic Strategies Cells 9(6), 1331. 2020 (SCI; IF: 5.1, 63/205=30.7 %, Cell Biology)
24. Cheng-Heng Wu, Cheng-Yi Chen, Chau-Ting Yeh, and Kwang-Huei Lin Radiosensitization of Hepatocellular Carcinoma through Targeting Radio-Associated MicroRNA International Journal of Molecular Sciences 21(5), 1859. 2020 (SCI; IF: 4.9, 66/313=21.1%, Biochemistry & Molecular Biology)
25. Hsiang-Cheng Chi, Chung-Ying Tsai, Chia-Siu Wang, Huang-Yu Yang, Chien-Hui Lo, Won-Jing Wang, Kam-Fai Lee, Li-Yin Lai, Ji-Hong Hong, Yen-Fang Chang, Ming-Ming Tsai, Chau-Ting Yeh, Cheng Heng Wu, Ching-Chuan Hsieh, Lu-Hai Wang, Wei-Jan Chen, and Kwang-Huei Lin DOCK6 Promotes Chemo- and Radioresistance of Gastric Cancer by Modulating WNT/β-Catenin Signaling and Cancer Stem Cell Traits Oncogene 39(37), 5933-5949. 2020 (SCI; IF: 6.9, 36/313=11.5%, Biochemistry & Molecular biology)
26. 26.  Cheng-Heng Wu, Chau-Ting Yeh, and Kwang-Huei Lin Thyroid Hormones Suppress FOXM1 Expression to Reduce Liver Cancer Progression Oncology Reports 44(4), 1686-1698. 2020 (SCI; IF: 3.8, 102/322=31.7 %, Oncology)
27. 27.  Ching-Ying Chen, Sheng-Ming Wu, Yang-Hsiang Lin, Hsiang-Cheng Chi, Syuan-Ling Lin, Chau-Ting Yeh, Wen-Yu Chuang, and Kwang-Huei Lin Induction of Nuclear Protein-1 by Thyroid Hormone Enhances Platelet-derived Growth Factor A Mediated Angiogenesis in Liver Cancer Theranostics 9(8), 2361-2379. 2019 (SCI; IF: 12.4, 8/189=4.2%, Medicine, Research & Experimental)
28. Hsiang-Cheng Chi, Chung-Ying Tsai, Ming-Ming Tsai, Chau-Ting Yeh, and Kwang-Huei Lin Molecular Functions and Clinical Impact of Thyroid Hormone-triggered Autophagy in Liver-related Diseases Journal of Biomedical Science 26(1), 24. 2019 (SCI, IF: 9.0, 15/189=7.9% Medicine, Research & Experimental)
29. Yu-Chin Liu, Chau-Ting Yeh, and Kwang-Huei Lin Molecular Functions of Thyroid Hormone Signaling in Regulation of Cancer Progression and Anti-Apoptosis Int. J. Mol. Sci. 20(20), 4986. 2019 (SCI; IF: 4.9, 66/313=21.1%, Biochemistry & Molecular Biology)
30. Po-Shuan Huang, Chia-Siu Wang, Chau-Ting Yeh, and Kwang-Huei Lin Roles of Thyroid Hormone-Associated microRNAs Affecting Oxidative Stress in Human Hepatocellular Carcinoma Int. J. Mol. Sci. 20(20). 5220. 2019 (SCI; IF: 4.9, 66/313=21.1%, Biochemistry & Molecular Biology)
31. Kam-Fai Lee, Ming-Ming Tsai, Chung-Ying Tsai, Chung-Guei Huang, Yu-Hsiang Ou, Ching-Chuan Hsieh, Hsi-Lung Hsieh, Chia-Siu Wang, and Kwang-Huei Lin DEK is a Potential Biomarker Associated with Malignant Phenotype in Gastric Cancer Tissues and Plasma Int. J. Mol. Sci. 20(22), 5689. 2019 (SCI; IF: 4.9, 66/313=21.1%, Biochemistry & Molecular Biology)