91猫先生

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生化暨分子生物学科

生化暨分子生物学科

洪锦堂老師new

洪锦堂

职称：教授兼科主任

研究室名称：抗新冠病毒药物研发实验室

最高学歷：Ph.D.

学校/国家：英国剑桥大学

分机号码：5156

电子邮件帐号：jimtong@mail.cgu.edu.tw

个人网页网址：

研究室现有：博士后研究员1人

博士班研究生2人

硕士班研究生4人

专任研究助理3人

大学部专题生2人

Update：2022/08/03

研究方向及研究室特色：(2022.7更新)

研究题目: 1. Drug discovery against RNA viruses，?2. Molecular biology of RNA viruses

研究方向:

1.我们实验室从事抗病毒植物新药与小分子药物的开发，希望从(1)临床复方或单味植物新药，(2)AI药物开发，来开发与筛选具抗流行性感冒病毒、新冠病毒与肠病毒的抑制药物，并研究其机转，以因应可能爆发之疫情。

2. 利用定量蛋白质体学技术/高通量次世代定序，鑑定药物之靶标蛋白质，透过miRNA/lncRNA表现差异，诱发讯号传递，了解宿主-病毒的相互调控，并研究其相关的抗病毒机制。

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最近五年所发表论文：

  1. Chang, Y. H., Lau, K. S., Kuo, R. L., and Horng*, J. T. (2017) dsRNA Binding Domain of PKR Is Proteolytically Released by Enterovirus A71 to Facilitate Viral Replication. Front Cell Infect Microbiol 7, 284 (IF:6.073, MICROBIOLOGY 33/136=24%)
  2. Chen, S. G., Cheng, M. L., Chen, K. H., Horng, J. T., Liu, C. C., Wang, S. M., Sakurai, H., Leu, Y. L., Wang, S. D., and Ho, H. Y. (2017) Antiviral activities of Schizonepeta tenuifolia Briq. against enterovirus 71 in vitro and in vivo. Sci Rep 7, 935
  3. Jheng, J. R., Lau, K. S., Lan, Y. W., and Horng, J. T. (2018) A novel role of ER stress signal transducer ATF6 in regulating enterovirus A71 viral protein stability. Journal of biomedical science 25, 9 (IF:12.771, MEDICINE, RESEARCH & EXPERIMENTAL 11/139=7.55%)
  4. Huang, C. G., Lee, L. A., Wu, Y. C., Hsiao, M. J., Horng, J. T., Kuo, R. L., Huang, C. H., Lin, Y. C., Tsao, K. C., Chen, M. C., Chen, T. C., and Shih, S. R. (2018) A pilot study on primary cultures of human respiratory tract epithelial cells to predict patients' responses to H7N9 infection. Oncotarget 9, 14492-14508
  5. Sethy, B., Hsieh, C. F., Yeh, C., Horng, J. T., and Hsieh, P. W. (2018) Design, synthesis & structure-activity relationships of a new class of antihuman enterovirus D68 & A71 agents. Future Med Chem 10, 1333-1347
  6. Tang, W. F., Huang, R. T., Chien, K. Y., Tang, P., and Horng*, J. T. (2018) Large-Scale Proteomic Identification of Targets of Cellular miR-197 Downregulated by Enterovirus A71. Journal of proteome research (IF=5.370 BIOCHEMICAL RESEARCH METHODS 16/79=21%)
  7. Sethy, B., Hsieh, C. F., Lin, T. J., Hu, P. Y., Chen, Y. L., Lin, C. Y., Tseng, S. N., Horng*, J. T., and Hsieh*, P. W. (2019) Design, Synthesis, and Biological Evaluation of Itaconic Acid Derivatives as Potential Anti-Influenza Agents. Journal of medicinal chemistry 62, 2390-2403 (IF=8.039, MEDICINAL CHEMISTRY 3/63=4 %)
  8. Hsieh, C.F., Jheng, J.R., Lin, G.H., Chen, Y.L., Ho, J.Y., Liu, C.J., Hsu, K.Y., Chen, Y.S., Chan, Y.F., Yu, H.M., Hsieh, P.W., Chern, J.H., Horng*, J.T., 2020. Rosmarinic acid exhibits broad anti-enterovirus A71 activity by inhibiting the interaction between the five-fold axis of capsid VP1 and cognate sulfated receptors. Emerg Microbes Infect 9, 1194-1205. (IF=19.568, MICROBIOLOGY 7/136 =4.78%)
  9. Chu, H.W., Sethy, B., Hsieh, P.W., and Horng*, J.T. (2021). Identification of Potential Drug Targets of Broad-Spectrum Inhibitors with a Michael Acceptor Moiety Using Shotgun Proteomics. Viruses 13. (IF=5.818, VIROLOGY 14/37 36%)
  10. Tang, W.F., Tsai, H.P., Chang, Y.H., Chang, T.Y., Hsieh, C.F., Lin, C.Y., Lin, G.H., Chen, Y.L., Jheng, J.R., Liu, P.C., et al. (2021). Perilla (Perilla frutescens) leaf extract inhibits SARS-CoV-2 via direct virus inactivation. Biomed J 44, 293-303 (IF= 7.892, BIOCHEMISTRY & MOLECULAR BIOLOGY 47/296=15.71%)
  11. Jheng, J.R., Chen, Y.S., and Horng*, J.T. (2021). Regulation of the proteostasis network during enterovirus infection: A feedforward mechanism for EV-A71 and EV-D68. Antiviral research 188, 105019. (IF=10.103, PHARMACOLOGY & PHARMACY 16/279 =5.56%)
  12. Hsieh, C.F., Chen, Y.L., Lin, G.H., Chan, Y.F., Hsieh, P.W., and Horng*, J.T. (2022). 3,4-Dicaffeoylquinic Acid from the Medicinal Plant Ilex kaushue Disrupts the Interaction Between the Five-Fold Axis of Enterovirus A-71 and the Heparan Sulfate Receptor. Journal of virology 96, e0054221. (IF=6.549, VIROLOGY 11/37=29.7%)
  13. Jheng, J.R., Hsieh, C.F., Chang, Y.H., Ho, J.Y., Tang, W.F., Chen, Z.Y., Liu, C.J., Lin, T.J., Huang, L.Y., Chern, J.H., et al. (2022). Rosmarinic acid interferes with influenza virus A entry and replication by decreasing GSK3beta and phosphorylated AKT expression levels. Journal of microbiology, immunology, and infection (in press) (IF=10.273, MICROBIOLOGY 17/136=12.5%)
  14. Chin, Y.F., Tang, W.F., Chang, Y.H., Chang, T.Y., Lin, W.C., Lin, C.Y., Yang, C.M., Wu, H.L., Liu, P.C., Sun, J.R., et al. (2022). Orally delivered perilla (Perilla frutescens) leaf extract effectively inhibits SARS-CoV-2 infection in a Syrian hamster model. J Food Drug Anal 30, 252-270. (IF= 6.157, PHARMACOLOGY & PHARMACY 45/279 =15.95%)

执行中的计画

Ongoing Research Support

MOST 109-2320-B-182 -026 -MY3?? Horng (PI) ??? 2020/08/01? ~?? 2023/07/31

衣康酸衍生物抑制流感病毒核酸蛋白出核的分子机转研究

MOST 109-2634-F-182-001???? Horng (co-PI) ?? 2021/03/01? ~? 2023/02/28

高教深根与特色中心计画The Featured Areas Research Center Program within the framework of the Higher Education? Sprout Project by the Ministry of Education (MOE) in Taiwan and the Ministry of Science and Technology.

MOST 109-2327-B-182 -003 -?? Horng (co-PI) ????? 2022/03/01 ?~ ? 2026/02/28

防疫科学研究中心-长庚大学暨長庚醫院The Research Center for Epidemic Prevention Science

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