91猫先生

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生化暨分子生物学科

生化暨分子生物学科

林光輝老師

吴嘉霖

职称：教授 兼 醫學系醫預科主任

研究室名称：学习与记忆研究室

最高学歷：博士

学校/国家：清华大学/台湾

分机号码：5159

电子邮件帐号：clwu@mail.cgu.edu.tw

个人网页网址：

研究室现有： 博士后研究员 1?人

博士班研究生? 1?人

硕士班研究生 3?人

专任研究助理 3?人

大学部专题生 6 人

Update：2022/08/08

研究方向及研究室特色：

人类如何将学习的经验转為记忆储存一直都是科学界最想解开的谜题。人类拥有高度学习与记忆的能力，使人类祖先能在恶劣的自然环境中生存，进而成為优势物种。俗话说:”一朝被蛇咬，十年怕草绳”就是一个例子。先前被毒蛇咬过而大难不死的人，将毒蛇的样子与危险讯号两种讯息关联在一起并转变為记忆储存，下次再看到相似外型的物体，先前储存的记忆便会被唤起，出现恐惧的感觉进而产生警戒。而这些记忆的形成是由大脑上千亿颗神经元共同运作的结果，但确切机制目前仍然未知。我们研究室利用果蝇作為模式生物了解大脑在学习与记忆过程中产生哪些生理变化。果蝇大脑仅有约十叁万颗神经细胞，相较於人脑由将近千亿颗神经细胞组成相对简单。我们利用大脑组织免疫染色搭配共軛焦显微镜技术观察果蝇大脑内神经分子的变化情形，进而了解记忆过程中大脑的分子变化情形。搭配活体大脑钙离子影像系统研究果蝇大脑在学习前与学习后的神经反应变化情形。另外利用动物行為学分析观察特定基因突变或特定神经细胞的神经活性改变是否影响果蝇学习与记忆能力。这些实验结果都将使我们更加了解记忆形成的大脑神经机制。

最近五年所发表论文：

  1. Chen SL, Liu BT, Lee WP, Liao SB, Deng YB, Wu CL, Ho SM, Shen BX, Khoo GH, Shiu WC, Chang CH, Shih HW, Wen JK, Lan TH, Lin CC, Tsai YC, Tzeng HF, Fu TF. (2022). WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour. Nature Communications, 13:2518/ doi.org/10.1038/s41467-022-30165-2
  2. Chiang MH, Ho SM, Wu HY, Lin YC, Tsai WH, Wu T, Lai TH, Wu CL. (2022). Drosophila Model for Studying Gut Microbiota in Behaviors and Neurodegenerative Diseases. Biomedicines, Mar; 10, 596. doi.org/10.3390/biomedicines10030596.
  3. Lee WP, Chiang MH, Chang LY, Shyu WH, Chiu TH, Fu TF, Wu T, Wu CL. (2021). Serotonin Signals Modulate Mushroom Body Output Neurons for Sustaining Water-Reward Long-Term Memory in Drosophila. Frontiers in Cell and Developmental Biology, Nov 11; 9:755574.
  4. Hsu CY, Yeh JY, Chen CY, Wu HY, Chiang MH,?Wu CL, Lin HJ, Chiu CH, Lai CH. (2021). Helicobacter pylori?cholesterol-α-glucosyltransferase manipulates cholesterol for bacterial adherence to gastric epithelial cells. Virulence, Dec;12(1):2341-2351.
  5. Cheng KC, Chen YH,?Wu CL, Lee WP, Cheung CHA, Chiang HC. (2021).Rac1 and Akt Exhibit Distinct Roles in Mediating Aβ-Induced Memory Damage and Learning Impairment. Molecular Neurobiology, Jul 17. doi: 10.1007/s12035-021-02471-1.
  6. Lee WP, Chiang MH, Chang LY, Lee JY, Tsai YL, Chiu TH, Chiang HC, Fu TF, Wu T, Wu CL*. (2020) Mushroom body subsets encode CREB2-dependent water-reward long-term memory in Drosophila. PLOS Genetics, 16(8): e1008963. (*corresponding author).
  7. Lien WY, Chen YT, Li YJ, Wu JK, Huang KL, Lin JR, Lin SC, Hou CC, Wang HD, Wu CL, Huang SY, Chan CC*. (2020). Lifespan regulation in α/β posterior neurons of the fly mushroom bodies by Rab27. Aging Cell, e13179 doi 10.1111/acel.13179.
  8. Shyu WH, Lee WP, Chiang MH, Chang CC, Fu TF, Chiang HC, Wu T, Wu CL* (2019). Electrical synapses between mushroom body neurons are critical for consolidated memory retrieval in Drosophila. PLOS Genetics, 15(5): e1008153. (*corresponding author).
  9. Sneapati B, Tsao CH, Juan YA, Chiu TH, Wu CL, Waddell S, Lin S*. (2019). A neural mechanism for deprivation state-specific expression of relevant memories in Drosophila. Nature Neuroscience, 22(12): 2029-2039.
  10. Chen YR, Li YH, Hsieh TC, Wang CM, Cheng KC, Wang L, Lin TY, Cheung CHA, Wu CL, Chiang H* (2019). Aging-induced Akt activation involves in aging-related pathologies and Aβ-induced toxicity. Aging Cell, 18(4) e12989.
  11. Chi KC, Tsai WC, Wu CL, Lin TY, Hueng DY (2019). An adult Drosophila glioma model for studying pathometabolic pathways of gliomagenesis. Molecular Neurobiology, 56(6): 4589-4599.
  12. Lien HM, Wu HY, Hung CL, Chen CJ, Wu CL, Chen KW, Huang CL, Chang SJ, Chen CC, Lin HJ, Lai CH* (2019). Antibacterial activity of ovatodiolide isolated from Anisomeles indica against Helicobacter pylori. Scientific Reports,?(9)1: 4205. doi: 10.1038/s41598-019-40735-y.
  13. Wu CL*, Chang CC, Wu JK, Chiang MH, Yang CH, Chiang HC (2018). Mushroom body glycolysis is required for olfactory memory in Drosophila. Neurobiology of Learning and Memory, 150: 13-19 (*corresponding author).
  14. Chen YA, Tzeng D TW, Huang YP, Lin CJ, Lo UG, Wu CL, Lin H, Hsieh JT, Tang CH, Lai CH* (2018). Antrocin sensitizes prostate cancer cells to radiotherapy through inhibiting PI3K/AKT and MAPK signaling pathways. Cancers, 11(1): 34. doi 10.3390/cancers11010034.
  15. Chen YA,?Shih HW,?Lin YC,?Hsu HY,?Wu TF,?Tsai CH,?Wu CL,?Wu HY,?Hsieh JT,?Tang CH,?Lai CH* (2018). Simvastatin?sensitizes?radioresistant prostate cancer cells by compromising DNA?double-strand break?repair. Frontiers in Pharmacology, 9: 600.
  16. Ji XR, Cheng KC, Chen YR, Lin TY, Cheung CHA, Wu CL, Chiang HC* (2018). Dysfunction of different cellular degeneration pathways contributes to specific β-amyloid42-induced pathologies. FASEB Journal, 32(3): 1375-1387.?
  17. Yang CN, Wu MF, Liu CC, Jung WH, Chang YC, Lee WP, Shiao YJ, Wu CL, Liou HH, Lin SK, Chan CC* (2017) Differential protective effects of connective tissue growth factor against Aβ neurotoxicity on neurons and glia. Human Molecular Genetics, 26(20): 3909-3921.
  18. Shyu WH, Chiu TH, Chiang MH, Cheng YC, Tsai YL, Fu TF, Wu T, Wu CL* (2017). Neural circuits for long-term water-reward memory processing in thirsty Drosophila. Nature Communications, 8: 15230; doi: 10.1038/ncomms15230 (*corresponding author).
  19. Chen SL, Chen YH, Wang CC, Yu YW, Tsai YC, Hsu HW, Wu CL, Wang PY, Chen LC, Lan TH*, Fu TF* (2017). Active and passive sexual roles that arise in Drosophila male-male courtship are modulated by dopamine levels in PPL2ab neurons. Scientific Reports, 7:44595/doi:10.1038/srep44595.

近五年内获奖情形及重要会议邀请演讲：

获奖：

  1. 2019长庚大学優良教师—教学奖
  2. 56届中华民国十大杰出青年—医学研究类
  3. 2018长庚大学優良教师—研究奖
  4. 2018中央研究院年轻学者研究着作奖—生命科学组
  5. 106年度科技部吴大猷先生纪念奖
  6. 2017长庚大学優良教师—研究奖

邀请演讲：

1. Wu CL, Invited speaker. Asia-Pancific Drosophila Neuroscience Conference（APDNC）. January 16-20, 2019, Taipei, Taiwan. Electrical synapses in Kenyon cells are critical for Drosophila olfactory memory.

2. Wu CL, Invited speaker. The Research Center of Developmental Biology and Research Medicine at National Taiwan University (NTUCDBRM). October 30th2018, Taipei, Taiwan. Dissecting neural path-ways for Drosophila water reward long-term memory.

3. Wu CL, Invited speaker. The 13thAcross the Taiwan Strait Symposium on Cell Biology. July 18th-22th2018, Xining, China. Parallel brain circuits regulate long-and short-term memories in fruit fly.

4. Wu CL, Invited speaker. EMBO Workshop on Neural Development. March 2nd-6rd2018, Taipei, Taiwan. Water reward memory in Drosophila.

5. Wu CL, Invited speaker. NPAS Symposium on Drosophila Neurobiology. July 26th2017, Taipei, Tai-wan. Water reward long-term memory in Drosophila.

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