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生化暨分子生物学科

生化暨分子生物学科

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郑邑荃老師

郑邑荃

职称： 教授

研究室名称：神经发育、退化、与肿瘤

最高学歷：Ph.D.

学校/国家：长庚大学

分机号码：3396

电子邮件帐号：yccheng@mail.cgu.edu.tw

个人网页网址：

研究室现有：博士后研究员1人

博士班研究生2人

硕士班研究生4人

专任研究助理1人

大学部专题生5人

Update：2023/02/01

研究方向及研究室特色：

研究目标：

1. 运动障碍疾病 (帕金森氏症、渐冻人)

我們實驗室透過與長庚醫療體系與國外研究機構合作，以遺傳分析和高通量研究發現許多新的基因與帕金森氏症及肌萎縮側索硬化症等运动障碍疾病有關。然而，這些基因在运动障碍中的病理作用和基本機制大多不清楚。我們採用神經毒劑、基因突變、誘導性轉殖基因等方法，建立了帕金森氏症和肌萎縮側索硬化症的動物模式，剖析候選基因的生理、病理功能及其調控途徑，並找出可作為治療用途的化學物質和分子以及營養補充品。

2. 脊髓损伤与再生

我们也试图找出在脊髓损伤后，参与在脊髓再生中的新的分子调控路径和细胞。在哺乳动物中，脊髓损伤会导致神经细胞损失，并造成永久性的残疾。相比之下，斑马鱼有能力再生其受伤的脊髓，并恢復活动能力，因此提供了一个有效的动物模式来开发潜在的治疗策略。我们已经确定了几个参与改善斑马鱼脊髓再生的分子，这对於非再生脊椎动物的成人神经再生来说开啟了一个新的治疗策略，因此，在未来也可能应用於脊髓损伤的细胞和分子治疗。

3. 神经发育与脑肿瘤

神经母细胞具有自我新生和多样分化的能力，能够分化為神经元、星形胶质细胞、寡树突胶细胞等多种神经细胞。在许多神经退行性疾病和脑肿瘤中，其存活、增殖、分化和迁移的调控路径经常被破坏或改变。因此，了解神经发育过程中的基因调控和讯息传递路径可以提供与神经退化和脑肿瘤发生的相关知识，并发现新的治疗方法和策略。我们正在研究不正常的发育过程是如何导致退化和肿瘤的，特别着重在Notch讯息传递路径在调节神经发育、神经退化和脑肿瘤发生中的作用，从而发展这些疾病的治疗方法。

4. 其他合作计画--遗传性肾臟疾病

台灣洗腎人數高居世界第一。我們長期與長庚醫院腎臟科醫師合作，建立了罹患遗传性肾臟疾病的斑馬魚模式，並使用腎臟螢光斑馬魚品系，以利用斑馬魚胚胎體透明可直接觀察腎臟病變之優勢，研究遗传性肾臟疾病中之分子調控機制及篩選治療藥物。

最近五年所发表论文：

  1. Wu YM, Huang PY, Cheng YC, Lee CH, Hsu MC, Lu JJ, Wang SH. (2021 Dec). Enhanced Virulence of Candida albicans by Staphylococcus aureus: Evidence in Clinical Bloodstream Infections and Infected Zebrafish Embryos. J Fungi (Basel). 7(12):1099
  2. Lin SJ, Huang YC, Chen HY, Fang JY, Hsu SY, Shih HY, Liu YC, Cheng YC*. (2021 Dec). RGS2 Suppresses Melanoma Growth via Inhibiting MAPK and AKT Signaling Pathways. Anticancer Res. 41(12):6135-6145.
  3. Yeh TH, Liu HF, Chiu CC, Cheng ML, Huang GJ, Huang YC, Liu YC, Huang YZ, Lu CS, Chen YC, Chen HY, Cheng YC*. (2021 Sep). PLA2G6 mutations cause motor dysfunction phenotypes of young-onset dystonia-parkinsonism type 14 and can be relieved by DHA treatment in animal models. Exp Neurol. 11;346:113863.
  4. Wu YM, Lee CH, Cheng YC, Lu JJ, Wang SH. (2020 Oct). Association between CAI microsatellite, multilocus sequence typing, and clinical significance within Candida albicans isolates. Medical Mycology. myaa090 [Epub ahead of print].
  5. Chiang MC, Nicol CJB, Cheng YC, Yen C, Lin CH, Chen SJ, Huang RN. (2020 May). Nanogold Neuroprotection in Human Neural Stem Cells Against Amyloid-beta-induced Mitochondrial Dysfunction. Neuroscience. 21;435:44-57.
  6. Wang SH, Chen CC, Lee CH, Chen XA, Chang TY, Cheng YC, Young JJ, Lu JJ. (2020 Jan [Epub 2019 Nov 15]). Fungicidal and anti-biofilm activities of trimethylchitosan-stabilized silver nanoparticles against Candida species in zebrafish embryos. International Journal of Biological Macromolecules, 143:724-731.
  7. Lin CH, Nicol CJB, Cheng YC, Yen C, Wang YS, Chiang MC. (2020 Jan (Epub 2019 Oct 3)). Neuroprotective effects of resveratrol against oxygen glucose deprivation induced mitochondrial dysfunction by activation of AMPK in SH-SY5Y cells with 3D gelatin scaffold. Brain Res. 1726:146492.
  8. Wang HL, Lu CS, Yeh TH, Shen YM, Weng YH, Huang YZ, Chen RS, Liu YC, Cheng YC, Chang HC, Chen YL, Chen YJ, Lin YW, Hsu CC, Lin HL, Chiu CH, Chiu CC. (2019 Oct) Combined Assessment of Serum Alpha-Synuclein and Rab35 is a Better Biomarker for Parkinson's Disease. J Clin Neurol. 15(4):488-495.
  9. Chiu CC, Yeh TH, Chen RS, Chen HC, Huang YZ, Weng YH, Cheng YC, Liu YC, Cheng AJ, Lu YC, Chen YJ, Lin YW, Hsu CC, Chen YL, Lu CS, Wang HL. (2019 Sep). Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade. Front Cell Neurosci. 13:399.
  10. Chiu CC, Lu CS, Weng YH, Chen YL, Huang YZ, Chen RS, Cheng YC, Huang YC, Liu YC, Lai SC, Lin KJ, Lin YW, Chen YJ, Chen CL, Yeh TH, Wang HL. (2019 June). PARK14 (D331Y) PLA2G6 Causes Early-Onset Degeneration of Substantia Nigra Dopaminergic Neurons by Inducing Mitochondrial Dysfunction, ER Stress, Mitophagy Impairment and Transcriptional Dysregulation in a Knockin Mouse Model. Mol Neurobiol. 56(6), 3835-3853.
  11. Chang MC, Cheng YC. (2019). ‘Zebrafish Model for Leptospirosis Kidney Disease’, in Yang CW, Pan MJ, Yang HY (eds.), Leptospirosis and the Kidney, Translational Research in Biomedicine, KARGER AG, Basel, Vol. 7, 76-81 - 2019
  12. Ku YC, Lai MH, Lo CC, Cheng YC, Qiu JT, Tarn WY, Lai MC. (2018 Dec). DDX3 Participates in Translational Control of Inflammation Induced by Infections and Injuries. Mol Cell Biol. 11;39(1). pii: e00285-18.
  13. Hsieh YC, Chiang MC, Huang TC, Yeh TH, Shih HY, Liu HF, Chen HY, Wang CP, Cheng YC* (2018 Dec). Pparα deficiency inhibits the proliferation of neuronal and glial precursors in the zebrafish central nervous system. Developmental Dynamics, 247(12):1264-1275.
  14. Lin CH, Nicol CJB, Cheng YC, Chen SJ, Yen CH, Huang RN, Chiang MC. (2018 Sep [Epub 2018 Jun]). Rosiglitazone rescues human neural stem cells from amyloid-beta induced ER stress via PPARγ dependent signaling. Exp Cell Res. 370(2):312-321.
  15. Yeh TH, Liu HF, Li YW, Lu CS, Shih HY, Chiu CC, Lin SJ, Huang YC, Cheng YC*. (2018, Jun [Epub 2019 Mar]). C9orf72 is Essential for Neurodevelopment and Motility Mediated by Cyclin G1. Experimental Neurology, 304:114-124.
  16. Wu YH, Lee YH, Shih HY, Chen SH, Cheng YC*, Chiu D. (2018, Jan). Glucose-6-phosphate dehydrogenase is indispensable in embryonic development by modulation of epithelial-mesenchymal transition via the NOX/Smad3/miR-200b axis. Cell Death and Disease, 9(1):10.
  17. Chiang MC, Nicol CJ, Cheng YC. (2018, May (online 2017, Oct)). Resveratrol activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against amyloid-beta-induced inflammation and oxidative stress. Neurochemistry International, Volume 115, , Pages 1-10
  18. Lin CH, Cheng YC, Nicol CJ, Lin KH, Yen CH, Chiang MC. (2017, Oct (online 2017, Aug)). Activation of AMPK is neuroprotective in the oxidative stress by advanced glycosylation end products in human neural stem cells. Experimental Cell Research, 15;359(2):367-373.
  19. Chiang MC, Cheng YC, Nicol CJ, Lin CH. (2017, Nov (online 2017, Sep)). The neuroprotective role of rosiglitazone in advanced glycation end product treated human neural stem cells is PPARgamma-dependent. International Journal of Biochemistry and Cell Biology, 92:121-133.
  20. Chiu CC, Yeh TH, Lu CS, Huang YC, Cheng YC, Huang YZ, Weng YH, Liu YC, Lai SC, Chen YL, Chen YJ, Chen CL, Chen HY, Lin YW, Wang HL. (2017 Sep). PARK14 PLA2G6 mutants are defective in preventing rotenone-induced mitochondrial dysfunction, ROS generation and activation of mitochondrial apoptotic pathway. Oncotarget. 8(45):79046-79060.
  21. Huang YC, Lin SJ, Shih HY, Chou CH, Chu HH, Chiu CC, Yuh CH, Yeh TH, Cheng YC*. (2017, Jun (2017, Sep). Epigenetic regulation of NOTCH1 and NOTCH3 by KMT2A inhibits glioma proliferation. Oncotarget. 8(38): 63110–63120.
  22. Chang MY, Ma TL, Hung CC, Tian YC, Chen YC, Yang CW, Cheng YC*. (2017, Aug). Metformin Inhibits Cyst Formation in a Zebrafish Model of Polycystin-2 Deficiency. Scientific Reports, 7(1):7161.
  23. Chung MM, Nicol CJ, Cheng YC, Lin KH, Chen YL, Pei D, Lin CH, Shih YN, Yen CH, Chen SJ, Huang RN, Chiang MC. (2017, Mar (online 2017, Feb)). Metformin activation of AMPK suppresses AGE-induced inflammatory response in hNSCs. Experimental Cell Research, 352(1):75-83.
  24. Lin SJ, Chiang MC, Shih HY, Chiang KC, Cheng YC* (2017, Jun (online 2017, Feb)). Spatiotemporal expression of foxo4, foxo6a, and foxo6b in the developing brain and retina are transcriptionally regulated by PI3K signaling in zebrafish. Development Genes and Evolution, doi: 10.1007/s00427-017-0575-6.
  25. Lin SJ, Chiang MC, Shih HY, Hsu LS, Yeh TH, Huang YC, Lin CY, Cheng YC*. (2017, Mar (online 2016, Dec)). Regulator of G protein signaling 2 (Rgs2) regulates neural crest development through Pparδ-Sox10 cascade. Biochimica et Biophysica Acta Molecular Cell Research, 1864 (3): 463–474.
  26. Shih HY, Hsu SY, Ouyang P, Lin SJ, Chou TY, Chiang MC, Cheng YC*. (2017, Apr (online 2016, Oct)). Bmp5 Regulates Neural Crest Cell Survival and Proliferation Via Two Different Signaling Pathways. Stem Cells, 35(4):1003-1014.

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