91猫先生

高龄照护人机介面辅助研究团队

高龄照护人机介面辅助研究团队

研究专长：动作控制与学习、中风上肢神经復健、脑影像学分析

研究团队成员:

吴菁宜主任、谢妤葳老师、李冠逸老师、郑嘉雄老师、陈柏伃老师、庄宜静老师、张雅如主任、林佩欣老师、林燕慧老师、郑智修老师、庄丽玲老师、谢宗勋老师、詹晓龙老师

研究计画：

目的:

针对社区老人或衰弱、退化性(如Parkinson disease)、脑血管疾病老人，建立筛检、预测疾病发生或再发的生物行為与神经生理侦测指标，并验证次级预防(secondary prevention)恶化、退化或再发之治疗方案，建立具实证治疗手法之虚拟实境与监测系统，以及推广至社区及居家之健康促进方案。

方法:

(一) 利用发展出之嗅觉、动作知觉及平衡测试仪，针对社区或退化性老人进行筛检，建立筛检动作及感觉障碍与神经损伤之系统。

(二) 针对生理、认知退化或障碍的长者，进行认知与运动功能检测，并设计认知与运动相关之训练组合，验证该训练对促进体能、生理、智能状况的成效

(叁) 针对脑血管疾病老人，根据目前新兴的非侵入性神经刺激技术，结合行為治疗（包含机器辅助治疗）研发复合疗法，改善生理认知功能，同时结合工程科技，建立即时监测及预警系统。

(四) 依据上述验证之训练方案，针对老化族群建立虚拟实境与监控系统，提供远距离医疗服务及居家训练。

相关研究主题：

1.老化对大脑感觉皮质抑制功能之影响：脑造影与行為学研究

2.初期中枢神经退化疾患其运动觉及嗅觉功能变化

3.疲劳之中枢与周边临床指标与虚拟实境抗疲劳训练模式之建立-应用於帕金森氏病患者

4.虚拟实境双重任务检测与训练平台设计-应用於帕金森氏病患者

5.利用感压鞋垫建立衰弱老化相关监测参数

6.机器辅助训练对中风患者於动作控制/表现、生活功能与生理反应之成效

7.有氧运动合併认知训练对中风患者之认知功能、生理指标、生活功能与生活品质之疗效

8.高龄者行动辅具操控虚拟训练

9.衰弱、失智、行动不便失能者之健康促进方案、虚拟实境介入系统研发(体感Kinect运动介入)，以体感偵測老年人之體適能與平衡能力

10.社區居住老人之不同模式运动介入方案的成效比較

跨国际研究合作：

1.社区中风患者自我效能及健康相关参数研究 (合作单位：加州州立大学多明格斯山分校职能治疗系黄妍华教授)

2.脑神经律动与脑功能研究 (合作单位：加拿大蒙特娄神经医学中心)

主要成果:

Chuang, I-C., Lin, K-C., Wu, C-Y.*, Hsien, Y-W., Liu, C-T., Chen, C-L. (2017 Accepted). Using rasch analysis to validate the motor activity log and the lower-functioning motor activity log in patients with stroke. Physical Therapy.

Chen, H-L., Lin, K-C., Hsieh, Y-W., Wu, C-Y. *, Liing, R-J., Chen, C-L. (2017 Accepted). A study of predictive validity, responsiveness, and mnimally clinically important difference of arm accelerometer in real-world activity of patients with chronic stroke. Clinical Rehabilitaion.

Cheng C-H.*, Tsai S-Y., Liu C-Y., Niddam D-M. (2017 Accepted) Automatic inhibitory function in the human somatosensory and motor cortices: An MEG-MRS study. Scientific Reports.

Cheng C-H.*, Sun H-H., Weng J-Q., Tseng Y-J. (2017 Accepted) Differential motor cortex excitability during observation of normal and abnormal goal-directed movement patterns. Neuroscience Research.

Li, K-Y. *, Wu, Y-H., & Chen, R-S. (2017). Interrater reliability of clinically performed manual arm position and motion matching test. Neuropsychiatry, 7(4), 290-296.

Li, K-Y. *, Chu, P-Y., & Pickett, A-K. (2017). The Effect of Dopaminergic medication on joint kinematics during haptic movements in individuals with Parkinson’s Disease. Behavioral Neurology, Article ID 2358386.

Hsieh, Y-W., Wu, C-Y., Wang, W-E., Lin, K-C., Chang, K-C., Chen, C-C., & Liu, C-T. (2017). Bilateral robotic priming before task-oriented approach in subacute stroke rehabilitation: A pilot randomized controlled trial. Clinical Rehabilitation, 31(2), 225-233.

Ma, H-Y., Lin, K-C., Hsieh, F-H., Chen, C-L., Tang, S F., & Wu, C-Y. (2017) Kinematic manifestation of arm-trunk performance during symmetric bilateral reaching after stroke: Within vs. beyond arm’s length. American Journal of Physical Medicine & Rehabilitation, 96(3), 146-151.

Hsieh,Y-W., Liing, R-J., Lin, K-C., Wu, C-Y., Liou, T-H., Lin, J-C., & Hung, J-W. (2016) Sequencing bilateral robot-assisted arm therapy and constraint-induced therapy improves reach to press and trunk kinematics in patients with stroke. Journal of NeuroEngineering and Rehabilitation, 13: 31,1-9.

Wu, C-Y., Chuang, I-C., Ma, H-I., Lin, K-C., & Chen, C-L. (2016). Validity and responsiveness of the revised nottingham sensation assessment for outcome evaluation in stroke rehabilitation. American Journal of Occupational Therapy, 70(2), 7002290040p1-8.

Hung, C-S., Hsieh, Y-W., Wu, C-Y., Lin, K-C., Lin, Y-T., & Chen, C-L. (2016). The effects of combination of robot-assisted therapy with task-specific or impairment-oriented training on motor function and quality of life in chronic stroke. American Academy of Physical Medicine and Rehabilitation, 1-8.

Cheng, C-H., Chan, P-Y., Hsieh, Y-W., & Chen. K-F. (2016) A meta-analysis of mismatch negativity in children with attention deficit-hyperactivity disorders. Neuroscience Letters, 612, 132-137.

Chan, P-Y., Cheng, C-H., Jhu, Y-J., Chen, C-L., & von Leupoldt, A. (2016) Being Anxious, Thinking Positively: The Effect of Emotional Context on Respiratory Sensory Gating. Frontiers in Physiology, 7: 19.

Cheng, C-H., Tseng, Y-J., Chen, R-S., & Lin, Y-Y. (2016) Reduced functional connectivity of somatosensory network in writer's cramp patients. Brain and Behavior, 6(3), e00433.

Cheng, C-H., Chan, P-Y., Niddam, D-M., Tsai, S-Y., Hsu, S-C., & Liu, C-Y. (2016) Sensory gating, inhibition control and gamma oscillations in the human somatosensory cortex. Scientific Reports, 6: 20437.

Huang, H-H. (2016) Commentary on "Modified Ride-on Car Use by Children with Complex Medical Needs". Pediatric Physical Therapy, 28(1): 108.

Lin, P-S., Hsieh, C-C., Cheng, H-S., Tseng, T-J., & Su, S-C. (2016) Association between Physical Fitness and Successful Aging in Taiwanese Older Adults. PloS One, 11(3): e0150389.

Liang, P-J., & Lin, P-S. (2016) Reliability and Validity of the Stroke Impact Scale 3.0 in Taiwanese Stroke Patients. Formosan Journal of Physical Therapy, 41(1), 28-36.

Lin, Y-C., Tsai, L-C., Cheng, H-Y., Lin, Y-H., & Cheng, C-H. (2016) Postural steadiness after prolonged standing on different sloped surface in young health adults. Biomedical Engineering: Applications, Basis and Communications, 28, 1650007.

Cheng, C-H., Chien, A., Hsu, W-L., Chen, C-P., & Cheng, H-Y. (2016) Investigation of the differential contributions of superficial and deep muscles on cervical spinal loads with changing head postures. PLoS One, 11(3), e0150608.

Cheng, C-H., Chien, A., Hsu W-L., Lai, D-M., Wang, S-F., &Wang, J-L. (2016) Identification of head control deficits following anterior cervical discectomy and fusion in patients with cervical spondylotic myelopathy. European Spine Journal, 25(6), 1855-1860.

Chen, C-C., Chuang, Y-F., Huang, A-C., Chen, C-K., & Chang, Y-J. (2016) The antalgic effects of non-invasive physical modalities on central post-stroke pain: a systematic review. Journal of Physical Therapy Science, 28(4), 1368-1373.

Lee, Y-Y., Hsieh, Y-W., Wu, C-Y., Lin, K-C., & Chen, C-K. (2015). Proximal Fugl-Meyer assessment scores predict clinically important upper limb improvement after 3 stroke rehabilitative interventions. Archives of Physical Medicine and Rehabilitation, 96, 2137-2144.

Chen, P-Y., Lin, K-C., Liing, R-J., Wu, C-Y., Chen, C-L., & Chang, K-C. (2015) Validity, responsiveness, and minimal clinically important difference of EQ-5D-5L in stroke patients undergoing rehabilitation. Quality of Life Research,. 25(6), 1585-1596.

Lee, Y-Y., Lin, K-C., Cheng, H-J., Wu, C-Y., Hsieh, Y-W., & Chen, C-K. (2015). Effects of combining robot-assisted therapy with neuromuscular electrical stimulation on motor impairment, motor and daily function, and quality of life in patients with chronic stroke: A double-blinded randomized controlled trial. Journal of NeuroEngineering and Rehabilitation, 12: 96, 1-10.

Fan, Y-T., Wu, C-Y., Liu, H-L., Lin, K-C., Wai, Y-Y., & Chen, Y-L. (2015). Neuroplastic changes in resting-state functional connectivity after stroke rehabilitation. Frontiers in Human Neuroscience, 9: 546, 1-12.

Fan, Y-T., Lin, K-C., Liu, H-L., Chen, Y-L., & Wu, C-Y. (2015). Changes in structural integrity are correlated with motor and functional recovery after post-stroke rehabilitation. Restorative Neurology and Neuroscience, 33(6), 835-844.

Wu, C-Y., & Chang, K-C. (2015). Constraint-induced movement therapy translated into practice. [Peer commentary on the paper “Efficacy of home-based Constraint-Induced Movement Therapy on chronic stroke patients' arm use in activities of daily living: Results of the cluster randomised-controlled HOMECIMT trial” by A. Barzel et al]. Lancet Neurology 14(9), 869-871.

Chuang, L-L., Lin, K-C., Hsu, A-L., Wu, C-Y., Chang, K-C., Li, Y-C., Chen, Y-L. (2015). Reliability and validity of a vertical numerical rating scale supplemented with a faces rating scale in measuring fatigue after stroke. Health and Quality of Life Outcomes,13: 91, 1-9.

Wu, C-Y., Chuang, I-C., Ma, H-I., Lin, K-C., & Chen, C-L. (2016). Validity and responsiveness of the revised nottingham sensation assessment for outcome evaluation in stroke rehabilitation. American Journal of Occupational Therapy, 70(2), 7002290040p1-8.

Li, K-Y., Lin, K-C., Chen, C-K., Liing, R-J., Wu, C-Y., & Chang, W-Y. (2015). Concurrent and predictive validity of arm kinematics with and without trunk restraint during a reaching task in stroke. Archives of Physical Medicine and Rehabilitation, 96(9), 1666-1675.

Lee, Y-Y., Lin, K-C., Wu, C-Y., Liao, C-H., Lin, J-C., Chen, C-L. (2015). Combining afferent stimulation and mirror therapy for improving muscular, sensorimotor, and daily functions after chronic stroke - A randomized, placebo-controlled study. American Journal of Physical Medicine & Rehabilitation, 94(10), 859-868.

Lin, K-C., Wu, Y-F., Chen, I-C., Tsai, P-L., Wu, C-Y., Chen, C-L. (2015). Dual-task performance involving hand dexterity and cognitive tasks and daily functioning in people with schizophrenia: A pilot study. American Journal of Occupational Therapy, 69(3), 6903250020p1-7.

Fan, Y-T., Wu, C-Y., Tsai, W-C., & Lin, K-C. (2015). Effects of lateralized light flash and color on unilateral neglect. Disability and Rehabilitation, 37(26), 2400-2406.

Lai, C-J., Liu, W-Y., Yang, T-F., Chen, C-L., Wu, C-Y., & Chan, A-C. (2015). Pediatric aquatic therapy on motor function and enjoyment in children diagnosed with cerebral palsy of various motor severities. Journal of Child Neurology, 30(2), 200-208.

Li, K-Y., Su, W-J., Fu, H-W., & Pickett, K-A. (2015) Kinesthetic deficit in children with developmental coordination. Research in Developmental Disabilities, 38, 125-133.

Li. K-Y., Fu, H-W., Yau, T-Y., Chen, R-S., & Wu, C-L. (2015) The use of the traditional Chinese version of the University of Pennsylvania Smell Identification test and the smell threshold test for healthy young and old adults in Taiwan. Perceptual and Motor Skills, 120(3), 928-943.

Konczak, J., Aman. J-E., Chen, Y-W., Li, K-Y., & Watson, P.J. (2015) Impaired Limb Proprioception in Adults With Spasmodic Dysphonia. Journal of Voice, 29(6), 777. e17-23.

Huang, Y-Z., Chang, Y-S., Hsu, M-J., Wong, A-M., & Chang, Y-J. (2015) Restoration of central programmed movement pattern by temporal electrical stimulation-assisted training in patients with spinal cerebellar atrophy. Neural Plasticity, 2015:462182.

Chen, C-C., Chuang, Y-F., Yang, H-C., Hsu, M-J., Huang, Y-Z., & Chang, Y-J. (2015) Neuromuscular electrical stimulation of the median nerve facilitates low motor cortex excitability in patients with spinocerebellar ataxia. Journal of Electromyography and Kinesiology, 25(1), 143-150.

Chan, P-Y., Cheng, C-H., & von Leupoldt, A. (2015) The effect of development in respiratory sensory gating measured by electrocortical activations. Neural Plasticity, 2015:389142.

Chan, P-Y., Cheng, C-H., Hsu, S-C., Liu, C-Y., Davenport, P-W., & von Leupoldt, A. (2015) Respiratory sensory gating measured by respiratory-related evoked potentials in generalized anxiety disorder. Frontiers in Psychology, 6, 957.

Cheng, C-H., Baillet, S., & Lin, Y-Y. (2015) Region-specific reduction of auditory sensory gating in older adults. Brain and Cognition, 101, 64-72.

Cheng, C-H., Chan, P-Y., Baillet, S., & Lin, Y-Y. (2015) Age-related reduced somatosensory gating is associated with altered alpha frequency desynchronization. Neural Plasticity, 2015:302878.

Cheng, C-H., Su, H-T., Yen, L-W., Liu, W-Y., & Cheng, H-Y. (2015) Long-term effects of therapeutic Eexercise on nonspecific chronic neck pain: a literature review. Journal of Physical Therapy Science, 27(4), 1271-1276.

Chen, C-Y., Chang, C-W., Lee, S-T., Chen, Y-C., Tang, S-F., Cheng, C-H., & Lin, Y-H. (2015) Is rehabilitation intervention during hospitalization enough for functional improvements in patients undergoing lumbar decompression surgery: a prospective randomized controlled study? Clinical Neurology and Neurosurgery, 129(Suppl 1), S41-46.

Huang, W-P., Wang, C-C., Hung, J-H., Chien, K-C., Liu, W-Y., Cheng, C-H., Ng, H-H., & Lin, Y-H. (2015) Joystick-controlled video console game practices for power wheelchairs indoor driving skills. Journal of Physical Therapy Science, 27(2), 495-498.

Yang, W-C., Cheng, C-H., Wang, H-K., Lin, K-H., & Hsu, W-L. (2015) Mulit-muscle coordination during a challenging stance. European Journal of Applied Physiology, 115(9), 1959-1966.

Hsieh, C-C., & Lin, P-S. (2015) Kinect Tai-Chi exercise for community-dwelling older people: A pilot study. The Journal of Long-Term Care, 19(3), 283-294.

Chen, H-C., Chen, C-L., Kang, L-J., Wu, C-Y., Chen, F-C., Hong, W-H. (2014). Improvement of upper extremity motor control and function after home-based constraint-induced therapy in children with unilateral cerebral palsy: Immediate and long-term effects. Archives of Physical Medicine and Rehabilitation, 95(8), 1423-1432.

Chen, C-L., Lin, K-C., Kang, L-J., Wu, C-Y., Chen, H-C., & Hsieh, Y-W. (2014). Potential predictors of functional outcomes after home-based constraint-induced therapy for children with cerebral palsy. American Journal of Occupational Therapy, 68(2), 159-166.

Chuang, L-L., Wu, C-Y., Lin, K-C., & Hsieh, C-J. (2014). Relative and absolute reliability of a vertical numerical pain rating scale supplemented with a faces pain scale after stroke. Physical Therapy, 94, 129-138.

Hsieh, Y-W., Lin, K-C., Horng, Y-S., Wu, C-Y., Wu, D-J., & Ku, F-L. (2014). Sequential combination of robot-assisted therapy and constraint-induced therapy in stroke rehabilitation: A randomized controlled trial. Journal of Neurology, 261(5), 1037-1045.

Hsieh, Y-W., Lin, K-C., Korivi, M., Lee, T-H., Wu, C-Y., & Wu, K-Y. (2014). The reliability and predictive ability of a biomarker of oxidative DNA damage on functional outcomes after stroke rehabilitation. International Journal of Molecular Sciences, 15(4), 6504-6516.

Hsieh, Y-W., Lin, K-C., Wu, C-Y., Lien, H-Y., Chen, J-L., Chen, C-C., & Chang, W-H. (2014). Predicting clinically significant changes in motor and functional outcomes after robot-assisted stroke rehabilitation. Archives of Physical Medicine and Rehabilitation, 95, 316-321.

Huang, P-C., Hsieh, Y-W., Wang, C-M., Wu, C-Y., Huang, S-C., & Lin, K-C. (2014). Predictors of motor, daily function, and quality of life improvements after upper extremity robot-assisted rehabilitation in stroke. American Journal of Occupational Therapy, 68(3), 325-333.

Lin, K-C., Chen, Y-T., Huang, P-C., Wu, C-Y., Huang. W-L., Yang, H-W., Lai, H-T., & Lu, H-J. (2014). Effect of mirror therapy combined with somatosensory stimulation on motor recovery and daily function in stroke patients: A pilot study. Journal of the Formosan Medical Association, 113(7), 422-428.

Lin, K-C., Huang, P-C., Chen, Y-T., Wu, C-Y., & Huang, W-L. (2014). Combining afferent stimulation and mirror therapy for rehabilitating motor function, motor control, ambulation, and daily functions after stroke. Neurorehabilitation and Neural Repair,28(2), 153-162.

Wu, C-Y., Liing, R-J., Chen, H-C., Chen, C-L., & Lin, K-C. (2014). Arm and trunk movement kinematics during seated reaching within and beyond arm’s length in patients with stroke: A validity study. Physical Therapy,94(6), 845-856.

Cheng, C-H., Cheng, H-Y., Chen, C-P., Lin, K-H., Liu, W-Y., Wang, S-F., Hsu, W-L., & Chuang, Y-F. (2014) Altered co-contraction of cervical muscles in young adults with chronic neck pain during voluntary neck motions. Journal of Physical Therapy Science, 26(4), 587-590.

Chien, A., Lai, D-M., Cheng, C-H., Wang, S-F., Hsu, W-L., & Wang. J-L. (2014) Translation, cross-cultural adaptation, and validation of a Chinese version of the Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire. Spine, 39(12), 963-970.

Fang, C-Y., Lee, B-R., & Chang, Y-J. (2014) The supraspinal excitability modulation before rapid and slow goal-directed movements in human. Formosan Journal of Physical Therapy, 39(1), 42-49.

Hsu, W-L., Lin, K-H., Yang, R-S., & Cheng, C-H. (2014) Use of motor abundance in old adults in the regulation of a narrow-based stance. European Journal of applied Physiology, 114(2), 261-271.

Huang, H-H., Ellis, T-D., Wagenaar, R-C., & Fetters, L. (2014) Effect of body-scaled information on reaching in children with hemiplegic cerebral palsy: a pilot study. Pediatric Physical Therapy, 26(1), 28-37.

Huang, H-H., Ragonesi, C-B., Stoner, T., Peffley, T., & Galloway, J-C. (2014) Modified toy cars for mobility and socialization: a case report of a child with cerebral palsy. Pediatric Physical Therapy, 26(1), 76-84.

Li, K-Y., & Wu, Y-H. (2014) Clinical evaluation of motion and position sense in the upper extremities of the elderly using motion analysis system. Clinical Interventions in Aging, 9, 1123-1131.

Lin, M-R., Hwang, H-F., Lin, P-S., & Chen, C-Y. (2014) Relationships of osteoporosis and follow-up length to recurrent falls in older men and women. Osteoporosis International, 25(3), 863-871.

Lin, P-S., Lin, T-C., Chen, C-C., Chi, S-F., Chen, C-K., & Wong, M-K. (2014) An simplified Comprehensive Assessment Tool for long-term care residents in Taiwan. Taiwan Journal of Physical Medicine and Rehabilitation, 42(1), 41-50.

Liu, W-Y., Chen, F-J., Lin, Y-H., Kuo, C-H., Lien, H-Y., & Yu, Y-J.. (2014) Postural alignment in children with bilateral spastic cerebral palsy using a bimanual interface for powered wheelchair control. Journal of Rehabilitation Medicine, 46(1), 39-44.

Logan, S-W., Huang, H-H., Stahlin, K., & Galloway, J-C. (2014) Modified ride-on car use for mobility and socialization: single-case study of an infant with Down syndrome. Pediatric Physical Therapy, 26(4), 418-426.

Li, K-Y., Hsu, W-C., & Lin, L-J. (2014) Effect of the recreational life review program on patients with dementia in an outpatient clinic: a preliminary study. Perceptual and Motor Skills, 119, 1-12.

Chan, P-Y., von Leupoldt, A., Liu, C-Y., & Hsu, S-c. (2014) Respiratory perception measured by cortical neural activations in individuals with generalized anxiety disorder. Respiratory Physiology & Neurobiology, 204, 36-40.

Chenivesse, C., Chan, P-Y., Tsai, H-W., Wheeler-Hegland, K., Silverman, E., von Leupoldt, A., Similowski, T., & Davenport, P. (2014) Negative emotional stimulation decreases respiratory sensory gating in healthy humans. Respiratory Physiology & Neurobiology, 204, 50-57.

Yu, C-H., Hung, Y-C., Lin, Y-H., Chen, G-X., Wei, S-H., Huang, C-H., & Chen, C-S. (2014) A 3D mathematical model to predict spinal joint and hip joint force for trans-tibial amputees with different SACH foot pylon adjustments. Gait & Posture, 40(4), 545-548.