老化相关心血管疾病研究团队
老化相关心血管疾病研究团队
老化相关心血管疾病研究团队
主持人: 王鐘賢 教授
研究专长：心肺物理治疗、运动生理、血栓/发炎免疫
研究团队成员:
王鐘贤老师、赵崇义老师、马蕴华老师、杨春茂老师、周淑娥老师、陈乔男老师、傅铁城医师、黄书群医师、王兆宏医师
研究计画:
说明: 本研究团队拟以多指标分析模式建立生物侦测标誌，如生理/功能标誌；探讨心肌组织重塑及心衰发展之分子机制及评估心臟復健对心衰相关标誌的影响，最终建立安全而有效的运动处方。
背景: 自民国96年起，心臟病已攀升至国人主要死亡原因之第二名，且死亡人数逐年增加。心臟衰竭是许多心臟疾病的病程终点，而在发病案例中有超过80%為高龄者。并且，罹患严重心臟衰竭之病人(NYHA功能分级IV)，平均年死亡率更高达40~50%。研究调查显示，由於人口老化、老年人口比例提高、以及冠状动脉疾病存活的病人数日益增加等原因，加剧了心臟衰竭病患增加的趋势。因此，降低心臟衰竭的发生与减缓心臟衰竭病生理进程的速度，是现今乃至未来极為重要的老化医疗议题。心臟衰竭患者可能因长期的神经内分泌代偿失衡，导致心肌功能更加衰弱恶化，并引发末端器官和骨骼肌缺血、发炎、与机能损伤，使其病患日常活动能力与生活品质更加降低。然而，有关心臟衰竭确切的病生理机转，目前尚未完全瞭解，亟待进一步研究釐清。由於心臟病变初期不易察觉，待病症出现时，常已迈入心臟衰竭阶段。因此，开发侦测早期心臟病变及尔后衍生心臟衰竭的生物与功能指标，对降低心臟衰竭的发生与改善心臟衰竭病程发展之临床决策判断，极其重要。
目的: 本研究团队拟以多指标分析模式建立生物侦测标誌，如生理/功能标誌；探讨心肌组织重塑及心衰发展之分子机制及评估心臟復健对心衰相关标誌的影响，最终建立安全而有效的运动处方。
方法: 以系统性评估模式建立心臟衰竭[生理与功能标誌]侦测方法，建立心臟血管流体动力特性、粥状血栓、血管新生、能量代谢等指标。
主要成果:
1. FU, Tieh-cheng, et al. Aerobic interval training improves oxygen uptake efficiency by enhancing cerebral and muscular hemodynamics in patients with heart failure. International journal of cardiology, 2013, 167.1: 41-50.
2. WANG, Jong-Shyan, et al. Exertional periodic breathing potentiates erythrocyte rheological dysfunction by elevating pro-inflammatory status in patients with anemic heart failure. International journal of cardiology, 2013, 167.4: 1289-1297.
3. WANG, Jong-Shyan, et al. Effect of aerobic interval training on erythrocyte rheological and hemodynamic functions in heart failure patients with anemia.International journal of cardiology, 2013, 168.2: 1243-1250.
4. CHEN, Yu-Wen, et al. Anemic comorbidity reduces capacity of endogenous thrombin generation and is associated with consumptive coagulopathy in patients with heart failure. International journal of cardiology, 2013, 168.5: 4965-4967.
5. CHEN, Yu-Wen; CHEN, Yi-Ching; WANG, Jong-Shyan. Absolute hypoxic exercise training enhances in vitro thrombin generation by increasing procoagulant platelet-derived microparticles under high shear stress in sedentary men. Clinical Science, 2013, 124.10: 639-649.
6. LEE, I.-Ta, et al. ATP stimulates PGE 2/cyclin D1-dependent VSMCs proliferation via STAT3 activation: role of PKCs-dependent NADPH oxidase/ROS generation. Biochemical pharmacology, 2013, 85.7: 954-964.
7. WENG, Tzu-Pin, et al. Effects of interval and continuous exercise training on CD4 lymphocyte apoptotic and autophagic responses to hypoxic stress in sedentary men. PloS one, 2013, 8.11: e80248.
8. HUANG, S. C., et al. Systemic vascular resistance is increased and associated with accelerated arterial stiffening change in patients with chronic cervical spinal cord injury. European journal of physical and rehabilitation medicine, 2013, 49.1: 41-49.
9. FU, Tieh-Cheng, et al. Cardiac Rehabilitation in Patients with Heart Failure.Acta Cardiologica Sinica, 2014, 30.5: 353-359.
10. WANG, Jong-Shyan, et al. Hypoxic exercise training improves cardiac/muscular hemodynamics and is associated with modulated circulating progenitor cells in sedentary men. International journal of cardiology, 2014, 170.3: 315-323.
11. WENG, Tzu-Pin, et al. Activation of lymphocyte autophagy/apoptosis reflects haemodynamic inefficiency and functional aerobic impairment in patients with heart failure. Clinical Science, 2014, 127.10: 589-602.
12. CHOW, Shu-Er, et al. Resveratrol induced ER expansion and ER caspase-mediated apoptosis in human nasopharyngeal carcinoma cells. Apoptosis, 2014, 19.3: 527-541.
13. HUANG, Shu-Chun, et al. Comparison of Cardiac Autonomic Nervous System Disturbed by Sleep Deprivation in Sex and Menstrual Phase. The Chinese journal of physiology, 2015, 58.2.
14. WANG, Jong-Shyan, et al. Effects of normoxic and hypoxic exercise regimens on monocyte-mediated thrombin generation in sedentary men. Clinical Science, 2015, 129.4: 363-374.
15. FU, Tieh-Cheng, et al. Aerobic Interval Training Elicits Different Hemodynamic Adaptations Between Heart Failure Patients with Preserved and Reduced Ejection Fraction. American Journal of Physical Medicine & Rehabilitation, 2016, 95.1: 15-27.
16. CHEN, Yi-Ching, et al. Interval and continuous exercise regimens suppress neutrophil-derived microparticle formation and neutrophil-promoted thrombin generation under hypoxic stress. Clinical Science, 2015, 128.7: 425-436.
17. TU, Shu-Ju, et al. Retention assessment of magnetic nanoparticles in rat arteries with micro-computed tomography. Physics in medicine and biology, 2014, 59.5: 1271.
18. LU, Yi-Ching, et al. Augmented cellular uptake of nanoparticles using tea catechins: effect of surface modification on nanoparticle–cell interaction.Nanoscale, 2014, 6.17: 10297-10306.
19. HO, Hung-Yao, et al. Characterization of global metabolic responses of glucose-6-phosphate dehydrogenase-deficient hepatoma cells to diamide-induced oxidative stress. Free Radical Biology and Medicine, 2013, 54: 71-84.
20. YANG, H. C., et al. Glucose 6-phosphate dehydrogenase deficiency enhances germ cell apoptosis and causes defective embryogenesis in Caenorhabditis elegans. Cell death & disease, 2013, 4.5: e616.
21. LIN, Hsin-Ru, et al. Proteome-wide dysregulation by glucose-6-phosphate dehydrogenase (G6PD) reveals a novel protective role for G6PD in aflatoxin B1-mediated cytotoxicity. Journal of proteome research, 2013, 12.7: 3434-3448.
22. CHENG, M. L., et al. Effective NET formation in neutrophils from individuals with G6PD Taiwan-Hakka is associated with enhanced NADP+ biosynthesis.Free radical research, 2013, 47.9: 699-709.
23. HO, H.-Y.; CHENG, M.-L.; CHIU, DT-Y. Glucose-6-phosphate dehydrogenase–beyond the realm of red cell biology. Free radical research, 2014, 48.9: 1028-1048.
24. TANG, Hsiang-yu, et al. Inability to maintain GSH pool in G6PD-deficient red cells causes futile AMPK activation and irreversible metabolic disturbance.Antioxidants & redox signaling, 2015, 22.9: 744-759.
25. YANG, Hung-Chi, et al. Glucose 6-phosphate dehydrogenase knockdown enhances IL-8 expression in HepG2 cells via oxidative stress and NF-κB signaling pathway. Journal of Inflammation, 2015, 12.1: 1.
26. WU, Yi-Hsuan, et al. Glucose-6-Phosphate Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-κB Signaling. Viruses, 2015, 7.12: 6689-6706.
27. CHEN, Chiao-Nan, et al. Home-‐Based Exercise May Not Decrease the Insulin Resistance in Individuals With Metabolic Syndrome. Journal of physical activity & health, 2015, 12.1: 74-79.
【獲獎】首創系統性及時評估運動心臟動力學變化與大腦/活動骨骼肌血流運行與氧氣利用的效率，榮獲「國家品質標章 (SNQ)」及2012年財團法人醫院評鑑暨醫療品質策進會最高獎項「醫療品質獎(HQIC)金獎」
【专利】王鐘賢: 智慧型腳踏車及操作方法
中華民國發明專利第I458521號(2012/10/19)
聯絡窗口: 楊玫齡 小姐 03-2118800# 3173
johfjk@mail.cgu.edu.tw