91猫先生

我们实验室着重於利用显微技术研究微生物与宿主组织交互作用，并利用黏膜共生真菌作為模型探讨这样的交互作用对微生物共生、感染与自体免疫疾病的影响。我们亦同时与台湾疾管署、位於巴黎巴斯德研究中心的世界卫生组织李斯特菌欧洲合作实验室、以及国内各大医学中心合作，利用基因体学研究李斯特菌全球演化，并进一步结合动物模型及实验室各种离体模型以了解李斯特菌症。我们欢迎有志於学习并从事感染症研究的学生加入我们的团队。

Current members (Updated on Nov. 2024)

博士生 PhD students (joined since-graduated)

曾国尧 (2019-2024)

顾子奇 (2020, 2018-2020 as a Master student in the lab)

陈瑋璘 (MMP PhD program; 2021, 2019-2021 as a Master student in the lab)

硕士生 (Master students)

王安妮 (2023)

陈婕恩 (2023)

陈宥嫣 (2024)

张庭瑄 (2024)

陈育丞 (2024)

论文与着作(笔耻产濒颈肠补迟颈辞苍)

1.       Hafner L, Gadin E, Huang L, Frouin A, Laporte F, Gaultier C, Vieira A, Maudet C, Varet H, Moura A, Bracq-Dieye H, Tessaud-Rita, Maury M, Dazas M, Legendre R, Gastineau P, Tsai YH, Coppée JY, Charlier C, Patin E, Chikhi R, Rocha E, Leclercq A, Disson O, Hugues Aschard, Lecuit M. Differential stress responsiveness determines intraspecies virulence heterogeneity and host adaptation in Listeria monocytogenes. Nat Microbiol. 2024 Nov 22. 

2.       Tseng KY, Huang YT, Huang YT, Su YT, Wang AN, Weng WY, Ke CL, Yeh YC, Wang JJ, Du SH, Gu ZQ, Chen WL, Lin CH, Tsai YH*. Regulation of candidalysin underlies Candida albicans persistence in intravascular catheters by modulating NETosis. PLoS Pathog. 2024 Jun 17;20(6):e1012319. doi: 10.1371/journal.ppat.1012319. *lead contact

3.       Tsai YH*, Moura A*, Gu ZQ, Chang JH, Liao YS, Teng RH, Tseng KY, Chang DL, Liu WR, Huang YT, Leclercq A, Lo HJ, Lecuit M, Chiou CS. Genomic surveillance of Listeria monocytogenes in Taiwan, 2014 to 2019. Microbiol Spectr. 2022 Dec 21;10(6):e0182522. doi: 10.1128/spectrum.01825-22. *co-first author

4.       Herrera-Heredia SA, Hsu HP, Kao CY, Tsai YH, Yamaguchi Y, Roers A, Hsu CL, Dzhagalov IL. Heparin is required for the formation of granules in connective tissue mast cells. Front Immunol. 2022 Nov 9;13:1000405. 

5.       Shih HP, Ding JY, Sotolongo Bellón J, Lo YF, Chung PH, Ting HT, Peng JJ, Wu TY, Lin CH, Lo CC, Lin YN, Yeh CF, Chen JB, Wu TS, Liu YM, Kuo CY, Wang SY, Tu KH, Ng CY, Lei WT, Tsai YH, Chen JH, Chuang YT, Huang JY, Rey FA, Chen HK, Chang TW, Piehler J, Chi CY, Ku CL. Pathogenic autoantibodies to IFN-γ act through the impedance of receptor assembly and Fc-mediated response. J Exp Med. 2022 Sep 5;219(9):e20212126. doi: 10.1084/jem.20212126. 

6.       Maudet C, Kheloufi M, Levallois S, Gaillard J, Huang L, Gaultier C, Tsai YH, Disson O, Lecuit M. Bacterial inhibition of Fas-mediated killing promotes neuroinvasion and persistence. Nature. 2022 Mar;603(7903):900-906.

7.       Huang YT, Kuo YW, Lee MR, Tsai YH, Teng LJ, Tsai MS, Liao CH, Hsueh PR. Clinical and molecular epidemiology of human listeriosis in Taiwan. Int J Infect Dis. 2021 Jan 28;104:718-724.

8.       Guo J, Ning XQ, Ding JY, Zheng YQ, Shi NN, Wu FY, Lin YK, Shih HP, Ting HT, Liang G, Lu XC, Kong JL, Wang K, Lu YB, Fu YJ, Hu R, Li TM, Pan KS, Li XY, Huang CY, Lo YF, Chang IY, Yeh CF, Tu KH, Tsai YH, Ku CL, Cao CW. Anti-IFN-γ autoantibodies underlie disseminated Talaromyces marneffei infections. J Exp Med. 2020 Dec 7;217(12):e20190502.

9.       Tsai YH* and Chen WL. Host lipid rafts as the gates for Listeria monocytogenes infection: a mini-review. Front Immunol. 2020 Aug 11;11;1666  *lead contact

10.    Gu ZQ, Tseng KY, and Tsai YH*. Candida gut commensalism and inflammatory disease. Medicine in Microecology 2020Mar;3:100008 * lead contact

11.    Chang CJ, Lu CC, Lin CS, Martel J, Ko YF, Ojcius DM, Wu TR, Tsai YH, Yeh TS, Lu JJ, Lai HC, and Young JD. Antrodia cinnamomea reduces obesity and modulates the gut microbiota in high-fat diet-fed mice. Int J Obes. (Lond) 2018Feb;42(2):231-243

12.    Wei CF*, Tsai YH*, Tsai SH, Lin CS, Chang CJ, Lu CC, Huang HC, Lai HC. Cross-talk between bacterial two-component systems drives stepwise regulation of flagellar biosynthesis in swarming development. Biochem Biophys Res Commun. 2017 Jul 15;489(1):70-75 *co-first author

13.    Lin CS*, Tsai YH*, Chen CC, Chang WW, Lin YC, Chang CJ, Tseng SF, Wu TR, Lu CC, Horng JT, Martel J, Ojcius DM, Young JD, Lai HC. An iron detection system determines bacterial swarming initiation and biofilm formation. Sci Rep. 2016Nov 15;6:36747 *co-first author

14.    Maury MM*, Tsai YH*, Charlier C, Touchon M, Chenal-Francisque V, Leclercq A, Criscuolo A, Gaultier C, Rousse S, Brisabois A, Disson O, Rocha EP, Brisse S, Lecuit M. Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity. Nat Genet. 2016 Mar 48(3)308-13 *co-first author

15.    Gessain G, Tsai YH, Travier L, Bonazzi M, Grayo S, Cossart P, Charlier C, Disson O, Lecuit M. PI3-kinase activation is critical for host barrier permissiveness to Listeria monocytogenes. J Exp Med. 2015 Feb 9;212(2):165-83.

16.    Tsai YH, Disson O, Bierne H, Lecuit M. Murinization of internalin extends its receptor repertoire, altering Listeria monocytogenes cell tropism and host responses. PLoS Pathog 2013;9(5):e1003381