1.
Cheng SF, Lin YT, Wang TH, Leu YL, Hsia KC, Lee WC, Feng CH, Kuo
CH, Yang SH, Wang MC, Liu CY, Hu PC, Hsieh YC, Yang CW, Wang SH, Yu JS, Chen
CY, Chen CC*. Corylin promotes healthy aging via RAGA-mTOR
suppression and sex-dependent activation of SIRT3. (2026) Nature Communications. doi: 10.1038/s41467-026-74184-9.
2. Liu YY, Chen
CC(co-first), Kuo CH, Leu YL,
Wang SH. Beneficial Effects of Corylin on Metabolic Dysfunction-Associated
Fatty Liver Disease. (2026) Antioxid
Redox Signal. 44(16-18):910-927.
doi: 10.1177/15230864261443781.
3. Chen CC, Wang TH, Leu YL, Chan CW, Chen YX, Chu TD, Chen CY. Magnolol
suppresses TKI-resistant EGFR-mutant lung cancer by inhibiting EGFR and
AXL-cMyc. (2026) Eur J
Pharmacol 28;1016:178607.
doi: 10.1016/j.ejphar.2026.178607. Epub 2026 Jan 27
4. Chen CC, Chen CY, Chou LF, Yeh CT, Liu YT, Chu YD, Lin HW, Chen KY, Yu
CC, Wang TH. Corylin attenuates oral squamous cell carcinoma progression
through c-Myc inhibition. (2025) J
Dent Sci. 20(4):2322-2331.
doi: 10.1016/j.jds.2025.04.014.
5. Leu YL, Cheng SF, Wang TH, Feng CH, Chen YJ, Hsieh YC, Lan YH, Chen CC*.
Increasing DNA damage sensitivity through corylin-mediated inhibition of
homologous recombination. (2024) Biomed
Pharmacother.
11;176:116864. doi: 10.1016/j.biopha.2024.116864
6. Chang TY, Lin MS, Chen CC
(co-first), Leu YL, Wang SH.
Isoxanthohumol reduces neointimal hyperplasia through the apelin/AKT pathway.
(2024) Biochim Biophys Acta
Mol Basis Dis.1870(4):167099.
doi: 10.1016/j.bbadis.2024.167099. Epub 2024 Feb 28. PMID: 38428686.
7. Chen CC, Chen CY, Yeh CT, Liu YT, Leu YL, Chuang WY, Shih YH, Chou LF,
Shieh TM, Wang TH. Corylin Attenuates CCl4-Induced Liver Fibrosis in Mice by
Regulating the GAS6/AXL Signaling Pathway in Hepatic Stellate Cells. (2023) Int J Mol Sci. doi:
10.3390/ijms242316936
8. Wang TH., Tseng WC., Leu YL., Chen CY., Lee WC., Chi YC., Cheng
SF., Lai CY., Kuo CH., Yang SL., Yang SH., Shen JJ., Feng CH., Wu CC., Hwang
TL., Wang CJ., Wang SH., Chen
CC*. The flavonoid corylin
exhibits lifespan extension properties in mouse. (2022) Nature Communications doi:10.1038/s41467-022-28908-2
9. Chen CC, Chen CY, Cheng SF, Shieh TM, Leu YL, Chuang WY, Liu KT, Ueng SH,
Shih YH, Chou LF, Wang TH. Hydroxygenkwanin Increases the Sensitivity of Liver
Cancer Cells to Chemotherapy by Inhibiting DNA Damage Response in Mouse
Xenograft Models. (2021) Int
J Mol Sci. 9;22(18):9766.
doi: 10.3390/ijms22189766
10. Wang TH, Chen
CC(co-first), Leu YL, Lee YS,
Lian JH, Hsieh HL, Chen CY. Palbociclib induces DNA damage and inhibits DNA
repair to induce cellular senescence and apoptosis in oral squamous cell
carcinoma. (2021) J Formos
Med Assoc.
18:S0929-6646(20)30609-4. doi: 10.1016/j.jfma.2020.12.009
11. Tseng WC, Chen CY, Chern CY, Wang CA, Lee WC, Chi YC, Cheng SF,
Kuo YT, Chiu YC, Tseng ST, Lin PY, Liou SJ, Li YC, Chen CC*.
Targeting HR Repair as a Synthetic Lethal Approach to Increase DNA Damage
Sensitivity by a RAD52 Inhibitor in BRCA2-Deficient Cancer Cells. (2021) Int J Mol Sci. Apr
23;22(9):4422. doi: 10.3390/ijms22094422.
12. Chen CC, Kuo CH, Leu YL, Wang SH. Corylin reduces obesity and insulin
resistance and promotes adipose tissue browning through SIRT-1 and β3-AR
activation. (2021) Pharmacol
Res. 27:105291. doi:
10.1016/j.phrs.2020.105291
13. Chen CY, Fang JY, Chen
CC(co-first), Chuang WY, Leu
YL, Ueng SH, Wei LS, Cheng SF, Hsueh C, Wang TH. 2-O-Methylmagnolol, a Magnolol
Derivative, Suppresses Hepatocellular Carcinoma Progression via Inhibiting
Class I Histone Deacetylase Expression. (2020) Frontiers in Oncology 10:1319. doi: 10.3389/fonc.2020.01319
14. Chen CY, Chen
CC(co-first), Chuang WY, Leu
YL, Ueng SH, Hsueh C, Yeh CT, Wang TH. Hydroxygenkwanin Inhibits Class I HDAC
Expression and Synergistically Enhances the Antitumor Activity of Sorafenib in
Liver Cancer Cells. (2020) Frontiers
in Oncology 25;10:216.
doi: 10.3389 /fonc.2020.00216
15. Chen CC, Li HY, Leu YL, Chen YJ, Wang CJ, Wang SH. Corylin Inhibits
Vascular Cell Inflammation, Proliferation and Migration and Reduces
Atherosclerosis in ApoE-Deficient Mice. (2020) Antioxidants 25;9(4)
doi: 10.3390/antiox9040275
16. Wang TH, Chen
CC(co-first), Huang KY, Shih
YM, Chen CY. High levels of EGFR prevent sulforaphane-induced reactive oxygen
species-mediated apoptosis in non-small-cell lung cancer cells. (2019) Phytomedicine 64:152926.
doi: 10.1016/j.phymed.2019.152926
17. Kuo CH, Leu YL, Wang TH, Tseng WC, Feng CH, Wang SH, Chen CC*.
A novel DNA repair inhibitor, diallyl disulfide (DADS), impairs DNA resection
during DNA double-strand break repair by reducing Sae2 and Exo1 levels. (2019) DNA repair 82:102690
doi: 10.1016/j.dnarep.2019.102690
18. Chen CC, Lee TY, Leu YL, Wang SH. Pigment epithelium-derived factor
inhibits adipogenesis in 3T3-L1 adipocytes and protects against high-fat
diet-induced obesity and metabolic disorders in mice. (2019) Translational Research. 210:26-42 doi: 10.1016/j.trsl.2019.04.006
19. Wang TH, Chen
CC (co-first), Hsiao YC, Lin
YH, Pi WC, Huang PR, Wang TV, Chen CY. Heterogeneous Nuclear Ribonucleoproteins
A1 and A2 Function in Telomerase-Dependent Maintenance of Telomeres. (2019) Cancers (Basel).
8;11(3) doi: 10.3390/cancers11030334
20. Chen CC, Chen CY, Wang SH, Yeh CT, Su SC, Ueng SH, Chuang WY, Hsueh C,
Wang TH. Melatonin Sensitizes Hepatocellular Carcinoma Cells to Chemotherapy
Through Long Non-Coding RNA RAD51-AS1-Mediated Suppression of DNA Repair.
(2018) Cancers (Basel). 10;10(9) DOI:
10.3390/cancers10090320
21. Chen CC, Chen CY, Ueng SH, Hsueh C, Yeh CT, Ho JY, Chou LF, Wang TH.
Corylin increases the sensitivity of hepatocellular carcinoma cells to
chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA
repair. (2018) Cell Death
Dis. 1;9(5):543
22. Chen CC, Huang JS, Wang TH, Kuo CH, Wang CJ, Wang SH, Leu YL.
Dihydrocoumarin, an HDAC Inhibitor, Increases DNA Damage Sensitivity by
Inhibiting Rad52. (2017) Int
J Mol Sci. 18(12),2655. doi:
10.3390/ijms18122655
23. Yeh CJ, Chen
CC (co-first), Leu YL, Lin MW,
Chiu MM, Wang SH. The effects of artocarpin on wound healing: in vitro and in
vivo studies. (2017) Scientific
reports; 7(1):15599. doi:
10.1038/s41598-017-15876-7
24. Chen CC, Liang CJ, Leu YL, Chen YL, Wang SH. Viscolin Inhibits In Vitro Smooth
Muscle Cell Proliferation and Migration and Neointimal Hyperplasia In Vivo. (2016) PLoS
one 11(12): e0168092.
doi:10.1371/journal.pone.0168092
25. Chen CC, Lin MW, Liang CJ, Wang SH. The Anti-Inflammatory Effects and
Mechanisms of Eupafolin in Lipopolysaccharide-Induced Inflammatory Responses in
RAW264.7 Macrophages. (2016) PLoS
One. 11(7):e0158662. doi:
10.1371/journal.pone.0158662
26. Wang SH, Lin PY, Chiu YC, Huang JS, Kuo YT, Wu JC, Chen CC*.
Curcumin-Mediated HDAC Inhibition Suppresses the DNA Damage Response and
Contributes to Increased DNA Damage Sensitivity. (2015) PLoS One.
10(7):e0134110. doi: 10.1371/journal.pone.0134110
27. Hu Z, Chen K, Xia Z, Chavez M, Pal S, Seol JH, Chen CC,
Li W, Tyler JK. Nucleosome loss leads to global transcriptional up-regulation
and genomic instability during yeast aging. (2014) Genes & Development, 15;28(4):396-408 DOI: 10.1101/gad.233221.113
28. Chen CC. & Tyler, J. K. Selective sensitization of cancer cells to
DNA damage by a HAT inhibitor. (2009) Cell
Cycle 8(18).
29. Chen CC. & Tyler, J. K. Chromatin assembly signals the end of repair.
(2008) Cell Cycle, 7, 3792-7.
30. Chen CC., Carson, J., Feser, J., Tamburini, B., Zabaronick, S., Linger,
J. & Tyler, J. K. Acetylation of lysine 56 on histone H3 drives chromatin
assembly after repair and signals for the completion of double-strand DNA
repair. (2008) Cell, 134, 231-43. OI: 10.1016/j.cell.2008.06.035