91猫先生

研究室资料

研究主题

1. 天然物在心血管疾病之机转探讨;针对冠状动脉的发生过程与机制，研究药物抑制血小板以及发炎细胞（嗜中性白血球）活化的相关机转，藉以研发对於心血管疾病的有效用药。研究过程中针对药物对血小板以及嗜中性白血球细胞内讯息传递之探讨，包括药物与细胞表面受体结合、酵素活性、自由基清除、细胞内钙离子变化，以及细胞内二级讯息传递之分析。
2. 探讨天然药物抗自由基之研究；自由基参与许多生理及病理现象，包括免疫反应、老化、甚至与癌症的发生亦有关连。自由基除了被白血球用於杀菌外，不正常过多的自由基对许多细胞造成不必要的伤害。因此藉由中草药对自由基清除的研究，对於中草药在药品或健康食品发展上，能有更进一步的帮助。
3. 研究血液中细胞与细胞间的交互作用；探讨细胞表面吸附分子生理及病理角色，并且配合天然药物对细胞间交互作用的影响，探讨吸附分子表现之讯息传递，以期瞭解吸附分子在血栓形成过程中，生理病理角色，并且藉由药物机制的探讨，找出能预防血栓形成更有效的药物。研究方法以全血的状态下进行，目的是可以达到较接近生理状态。
4. 研究天然药物调控人类嗜中性白血球与血小板交互作用机转、探讨血小板刺激嗜中性白血球细胞外陷阱捕捉&苍产蝉辫;(neutrophil extracellular traps; NET) 的机转与药物效果，并以动物血栓及肝臟再灌流模式，评估天然药物的应用。

论文着作

*, corresponding author

1. Huang TH, Hsieh PW, Chen TJ, Tsai HJ, Cheng JC, Liao HR, Kuo SL, Tseng CP. Melastoma malabathricum L. Suppresses Neutrophil Extracellular Trap Formation Induced by Synthetic Analog of Viral Double-Stranded RNA Associated with SARS-CoV-2 Infection. Pathogens. 2023, 17;12(2):341. (SCI) (IF: 3.3; R/C=70/161 in MICROBIOLOGY)
2.  Liao HR*, Kao YY, Leu YL, Liu FC, Tseng CP. Larixol inhibits fMLP-induced superoxide anion production and chemotaxis by targeting the βγ subunit of Gi-protein of fMLP receptor in human neutrophils. Biochem Pharmacol. 2022, 201:115091. (SCI) (IF: 6.100; R/C=46/279 in PHARMACOLOGY & PHARMACY)
3. Liao HR*, Lin CH, Chen JJ, Liu FC, Tseng CP. The anti-inflammatory effect of ε-viniferin by specifically targeting formyl peptide receptor 1 on human neutrophils. Chem Biol Interact. 2021, 345:109490. (SCI) (IF: 5.168; R/C=73/279 in PHARMACOLOGY & PHARMACY)
4. Chu YC, Chang CH, Liao HR, Fu SL, Chen JJ. Anti-Cancer and Anti-Inflammatory Activities of Three New Chromone Derivatives from the Marine-Derived Penicillium citrinum. Mar Drugs. 2021, 19(8):408. (SCI) (IF: 6.085; R/C=10/63 in CHEMISTRY, MEDICINAL)
5. Tsai HJ, Cheng JC, Kao ML, Chiu HP, Chiang YH, Chen DP, Rau KM, Liao HR, Tseng CP. Integrin αIIbβ3 outside-in signaling activates human platelets through serine 24 phosphorylation of Disabled-2. Cell Biosci. 2021, 11(1):32. (SCI) (IF: 9.606; R/C=31/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
6. Chu YC, Chang CH, Liao HR, Cheng MJ, Wu MD, Fu SL, Chen JJ. Rare Chromone Derivatives from the Marine-Derived Penicillium citrinum with Anti-Cancer and Anti-Inflammatory Activities. Mar Drugs. 2021, 19(1):25. (SCI) (IF: 6.085; R/C=10/63 in CHEMISTRY, MEDICINAL)
7. Tseng CP, Huang YL, Chang YW, Liao HR, Chen YL, Hsieh PW. Polysaccharide-containing fraction from Artemisia argyi inhibits tumor cell-induced platelet aggregation by blocking interaction of podoplanin with C-type lectin-like receptor 2. J Food Drug Anal. 2020, 28(1):115-123. (SCI) (IF: 6.157; R/C=45/279 in PHARMACOLOGY & PHARMACY).
8. Wang SL, Liao HR, Cheng MJ, Shu CW, Chen CL, Chung MI, Chen JJ. Four New 2-(2-Phenylethyl)-4H-chromen-4-one Derivatives from the Resinous Wood of Aquilaria sinensis and Their Inhibitory Activities on Neutrophil Pro-Inflammatory Responses. Planta Med. 2018, 84(18):1340-1347. (SCI) (IF: 3.007; R/C=41/63 in CHEMISTRY, MEDICINAL)
9. Liao HR, Chen IS, Liu FC, Lin SZ, Tseng CP. 2',3-dihydroxy-5-methoxybiphenyl suppresses fMLP-induced superoxide anion production and cathepsin G release by targeting the β-subunit of G-protein in human neutrophils. Eur J Pharmacol. 2018, 829:26-37. (SCI) (IF: 5.195; R/C=71/279 in PHARMACOLOGY & PHARMACY)
10. Chang YW, Tseng CP, Lee CH, Hwang TL, Chen YL, Su MT, Chong KY, Lan YW, Wu CC, Chen KJ, Lu FH, Liao HR, Hsueh C, Hsieh PW. β-Nitrostyrene derivatives attenuate LPS-mediated acute lung injury via the inhibition of neutrophil-platelet interactions and NET release. Am J Physiol Lung Cell Mol Physiol. 2018, 314(4):L654-L669. (SCI) (IF: 6.011; R/C=12/81 in PHYSIOLOGY)
11. Tsai HJ, Chien KY, Liao HR, Shih MS, Lin YC, Chang YW, Cheng JC, Tseng CP. Functional links between Disabled-2 Ser723 phosphorylation and thrombin signaling in human platelets. J Thromb Haemost. 2017, 15(10):2029-2044. (SCI) (IF: 16.036; R/C=3/67 in PERIPHERAL VASCULAR DISEASE)
12. Cheng LY, Liao HR, Chen LC, Wang SW, Kuo YH, Chung MI, Chen JJ. Naphthofuranone derivatives and other constituents from Pachira aquatica with inhibitory activity on superoxide anion generation by neutrophils. Fitoterapia. 2017, 117:16-21. (SCI) (IF: 3.204; R/C=166/279 in PHARMACOLOGY & PHARMACY)
13. Chen JJ, Tsai TH, Liao HR, Chen LC, Kuo YH, Sung PJ, Chen CL, Wei CS. New Sesquiterpenoids and Anti-Platelet Aggregation Constituents from the Rhizomes of Curcuma zedoaria. Molecules. 2016, 21(10):1385. (SCI) (IF: 4.927; R/C=114/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
14. Liao HR, Chien CR, Chen JJ, Lee TY, Lin SZ, Tseng CP. The anti-inflammatory effect of 2-(4-hydroxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol by targeting Lyn kinase in human neutrophils. Chem Biol Interact. 2015, 236:90-101. (SCI) (IF: 5.168; R/C=73/279 in PHARMACOLOGY & PHARMACY)
15. Chang YW, Hsieh PW, Chang YT, Lu MH, Huang TF, Chong KY, Liao HR, Cheng JC, Tseng CP. Identification of a novel platelet antagonist that binds to CLEC-2 and suppresses podoplanin-induced platelet aggregation and cancer metastasis. Oncotarget. 2015, 6(40):42733-48. (SCI) (IF: 5.168; R/C=44/217 in ONCOLOGY)
16. Tseng WL, Chen TH, Huang CC, Huang YH, Yeh CF, Tsai HJ, Lee HY, Kao CY, Lin SW, Liao HR, Cheng JC, Tseng CP. Impaired thrombin generation in Reelin-deficient mice: a potential role of plasma Reelin in hemostasis. J Thromb Haemost. 2014, 12(12):2054-64. (SCI) (IF: 16.036; R/C=3/67 in PERIPHERAL VASCULAR DISEASE)
17. Kuo WL, Liao HR, Chen JJ. Biflavans, Flavonoids, and a Dihydrochalcone from the Stem Wood of Muntingia calabura and Their Inhibitory Activities on Neutrophil Pro-Inflammatory Responses. Molecules. 2014, 19(12):20521-20535. (SCI) (IF: 4.927; R/C=114/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
18. Chuang LP, Chen NH, Lin SW, Chang YL, Liao HR, Lin YS, Chao IJ, Lin Y, Pang JH. Increased C-C chemokine receptor 2 gene expression in monocytes of severe obstructive sleep apnea patients and under intermittent hypoxia. PLoS One. 2014, 9(11):e113304. (SCI) (IF: 3.752; R/C=29/73 in MULTIDISCIPLINARY SCIENCES)
19. Liu FC, Liou JT, Liao HR, Mao CC, Yang P, Day YJ. The anti-aggregation effects of ondansetron on platelets involve IP3 signaling and MAP kinase pathway, but not 5-HT3-dependent pathway. Thromb Res. 2012, 130(3):e84-94. (SCI) (IF: 10.407; R/C=6/67 in PERIPHERAL VASCULAR DISEASE)
20. Liu FC, Day YJ, Liou JT, Yu HP, Liao HR*. Splitomicin inhibits fMLP-induced superoxide anion production in human neutrophils by activate cAMP/PKA signaling inhibition of ERK pathway. Eur J Pharmacol, 2012, 688(1-3):68-75. (SCI) (IF: 5.195; R/C=71/279 in PHARMACOLOGY & PHARMACY)
21. Liao HR*, Chen JJ, Chien YH, Lin SZ, Lin S, Tseng CP. 5-Hydroxy-7-methoxyflavone inhibits N-formyl-L-methionyl-L-leucyl- Lphenylalanine-induced superoxide anion production by specific modulate membrane localization of Tec with a PI3K independent mechanism in human neutrophils. Biochem Pharmacol. 2012, 84(2):182-91. (SCI) (IF: 6.100; R/C=46/279 in PHARMACOLOGY & PHARMACY)
22. Chang MC, Wang TM, Yeung SY, Jeng PY, Liao CH, Lin TY, Lin CC, Lin BR, Jeng JH. Antiplatelet effect by p-cresol, a uremic and environmental toxicant, is related to inhibition of reactive oxygen species, ERK/p38 signaling and thromboxane A2 production. Atherosclerosis. 2011, 219(2):559-65. (SCI) (IF: 6.847; R/C=11/67 in PERIPHERAL VASCULAR DISEASE)
23. Chang-Hui Liao*, Jih-Jung Chen, Jieru Egeria Lin, Chia-Hsin Liu, Ching-Ping Tseng, Yuan-Ji Day. 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,7-dimethoxy-4H-chromen-4-one (MSF-2) suppresses fMLPmediated respiratory burst in human neutrophils by inhibiting phosphatidylinositol 3-kinase activity. Journal of cellular physiology, 2011, 226(6):1519-30. (SCI) (IF: 6.513; R/C=10/81 in PHYSIOLOGY)
24. Liou BJ, Chang HS, Wang GJ, Chiang MY, Liao CH, Lin CH, Chen IS. Secondary metabolites from the leaves of Neolitsea hiiranensis and the anti-inflammatory activity of some of them. Phytochemistry. 2011, 72(4-5):415-22. (SCI) (IF: 4.004; R/C=161/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY)

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