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中医学系

中医学系
:::
陈金銓 教授

陈金銓 教授/ Chin-Chuan Chen

职称： 教授

现职： 天然药物研究所教授

信箱： chinchuan@mail.cgu.edu.tw

电话： 03-2118800转3719

学歷： 美國科羅拉多大學醫學分校 生化暨分子遺傳博士

专长领域： 生物化学、分子生物学、遗传学、表观遗传学、微生物天然物

个人网页：

研究主题

本实验室以酵母菌(Saccharomyces cerevisiae)、人类细胞、和小鼠模式进行以下叁大主题之研究：

  1. 中草药/天然药物调控DNA修补之分子机转与应用

臨床研究顯示，許多中草药對於合併放射治療有一定的增效作用，其中一個分子原理，是利用中草药抑制細胞的DNA修补机制，来增加癌症细胞的放射线敏感性。因此研究中药物如何调控DNA修补之分子机制，将有助於设计和发展合併放射治疗的新药物。

  1. 中草药對壽命機制之調控與延長壽命/抗肥胖药物之筛选
目前筛选增加寿命药物的系统极少，本实验室利用一套新颖的筛选系统大量筛选具有延长寿命功效的药物，并研究其分子机制。针对人口老化日趋严重的社会现象，此类型健康食品可用於预防及治疗老化相关的病状，更可望大量减少未来老年人口的医疗资源支出，真正达到健康老化的最终目的。
  1. 研发新型预防及治疗新型冠状肺炎（COVID-19）药物
目前对於颁翱痴滨顿-19病毒感染并无治癒方法，随着全球疫情升温，各国迫切地需要找寻更多治疗和预防的潜力药物，最近研究证实罢惭笔搁厂厂2对於厂础搁厂-颁翱痴-2进入及体内传播扮演重要角色，若能使用罢惭笔搁厂厂2抑製剂抑制病毒进入细胞，则有助於COVID-19的治疗。目前本实验致力於筛选具有此一特性之药物并瞭解其分子药理积转，可望作為治疗颁翱痴滨顿-19的候选药物并期望抑制疫情的扩张。

荣誉事蹟

专利

  1. 陈金銓，吕彦礼，黄聪龙，方嘉佑，潘台龙，

专利名稱：哺乳類SIRT1的活化剂，

台灣专利證號：I556818，

专利期限：2016.11.11-2035.08.06

  1. 陈金銓，吕彦礼，王淑慧，专利名稱：哺乳類

专利名稱：TOR的抑制剂，

台灣专利證號：I586351，

专利期限：2017.06.11-2036.02.15

  1. 陈金銓, 王淑慧, 吕彦礼

专利名稱：哺乳類SIRT1的活化剂，

美國专利證號：US 9,795,588 B2，

    专利期限：2016.08~ 2036.08

实验室成员与活动照片

博士班研究生 1 人
硕士班研究生 6人
专任研究助理 3 人

论文着作

  1. Wang TH., Tseng WC., Leu YL., Chen CY., Lee WC., Chi YC., Cheng SF., Lai CY., Kuo CH., Yang SL., Yang SH., Shen JJ., Feng CH., Wu CC., Hwang TL., Wang CJ., Wang SH., Chen CC*. The flavonoid corylin exhibits lifespan extension properties in mouse. (2022) Nature communications doi:10.1038/s41467-022-28908-2
  2. Chen CC, Chen CY, Cheng SF, Shieh TM, Leu YL, Chuang WY, Liu KT, Ueng SH, Shih YH, Chou LF, Wang TH. Hydroxygenkwanin Increases the Sensitivity of Liver Cancer Cells to Chemotherapy by Inhibiting DNA Damage Response in Mouse Xenograft Models. (2021) Int J Mol Sci. Sep 9;22(18):9766. doi: 10.3390/ijms22189766
  3. Tseng WC, Chen CY, Chern CY, Wang CA, Lee WC, Chi YC, Cheng SF, Kuo YT, Chiu YC, Tseng ST, Lin PY, Liou SJ, Li YC, Chen CC*. Targeting HR Repair as a Synthetic Lethal Approach to Increase DNA Damage Sensitivity by a RAD52 Inhibitor in BRCA2-Deficient Cancer Cells. (2021) Int J Mol Sci. Apr 23;22(9):4422. doi: 10.3390/ijms22094422.
  4. Chen CC, Kuo CH, Leu YL, Wang SH. Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and β3-AR activation. (2020) Pharmacol Res. 27:105291. doi: 10.1016/j.phrs.2020.105291
  5. Chen CY, Fang JY, Chen CC(co-first), Chuang WY, Leu YL, Ueng SH, Wei LS, Cheng SF, Hsueh C, Wang TH. 2-O-Methylmagnolol, a Magnolol Derivative, Suppresses Hepatocellular Carcinoma Progression via Inhibiting Class I Histone Deacetylase Expression. (2020) Frontiers in Oncology 10:1319. doi: 10.3389/fonc.2020.01319
  6. Chen CY, Chen CC(co-first), Chuang WY, Leu YL, Ueng SH, Hsueh C, Yeh CT, Wang TH. Hydroxygenkwanin Inhibits Class I HDAC Expression and Synergistically Enhances the Antitumor Activity of Sorafenib in Liver Cancer Cells. (2020) Frontiers in Oncology 25;10:216. doi: 10.3389 /fonc.2020.00216
  7. Chen CC, Li HY, Leu YL, Chen YJ, Wang CJ, Wang SH. Corylin Inhibits Vascular Cell Inflammation, Proliferation and Migration and Reduces Atherosclerosis in ApoE-Deficient Mice. (2020) Antioxidants 25;9(4) doi: 10.3390/antiox9040275
  8. Wang TH, Chen CC(co-first), Huang KY, Shih YM, Chen CY. High levels of EGFR prevent sulforaphane-induced reactive oxygen species-mediated apoptosis in non-small-cell lung cancer cells. (2019) Phytomedicine 64:152926. doi: 10.1016/j.phymed.2019.152926
  9. Kuo CH, Leu YL, Wang TH, Tseng WC, Feng CH, Wang SH, Chen CC*. A novel DNA repair inhibitor, diallyl disulfide (DADS), impairs DNA resection during DNA double-strand break repair by reducing Sae2 and Exo1 levels. (2019) DNA repair 82:102690 doi: 10.1016/j.dnarep.2019.102690
  10. Chen CC, Lee TY, Leu YL, Wang SH. Pigment epithelium-derived factor inhibits adipogenesis in 3T3-L1 adipocytes and protects against high-fat diet-induced obesity and metabolic disorders in mice. (2019) Translational Research. 210:26-42 doi: 10.1016/j.trsl.2019.04.006
  11. Wang TH, Chen CC (co-first), Hsiao YC, Lin YH, Pi WC, Huang PR, Wang TV, Chen CY. Heterogeneous Nuclear Ribonucleoproteins A1 and A2 Function in Telomerase-Dependent Maintenance of Telomeres. (2019) Cancers (Basel). 8;11(3) doi: 10.3390/cancers11030334
  12. Wang TH, Hsueh C, Chen CC, Li WS, Yeh CT, Lian JH, Chang JL, Chen CY. Melatonin Inhibits the Progression of Hepatocellular Carcinoma through MicroRNA Let7i-3p Mediated RAF1 Reduction. (2018) Int J Mol Sci. 10;19(9), 380. doi: 10.3390/ijms19092687
  13. Chen CC, Chen CY, Wang SH, Yeh CT, Su SC, Ueng SH, Chuang WY, Hsueh C, Wang TH. Melatonin Sensitizes Hepatocellular Carcinoma Cells to Chemotherapy Through Long Non-Coding RNA RAD51-AS1-Mediated Suppression of DNA Repair. (2018) Cancers (Basel). 10;10(9) DOI: 10.3390/cancers10090320
  14. Chen CC, Chen CY, Ueng SH, Hsueh C, Yeh CT, Ho JY, Chou LF, Wang TH. Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair. (2018) Cell Death Dis. 1;9(5):543
  15. Huang TH, Fowler F, Chen CC, Shen ZJ, Sleckman B, Tyler JK. The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells. (2018) Mol Cell. 1;69(5):879-892.e5. doi: 10.1016/j.molcel.2018.01.031
  16. Chen CY, Chen CC, Shieh TM, Hsueh C, Wang SH, Leu YL, Lian JH, Wang TH. Corylin Suppresses Hepatocellular Carcinoma Progression via the Inhibition of Epithelial-Mesenchymal Transition, Mediated by Long Noncoding RNA GAS5. (2018) Int J Mol Sci. 19(2), 380. doi: 10.3390/ijms19020380
  17. Chen CC, Huang JS, Wang TH, Kuo CH, Wang CJ, Wang SH, Leu YL. Dihydrocoumarin, an HDAC Inhibitor, Increases DNA Damage Sensitivity by Inhibiting Rad52. (2017) Int J Mol Sci. 18(12),2655. doi: 10.3390/ijms18122655
  18. Chen CC, Kao CP, Chiu MM, Wang SH. The anti-cancer effects and mechanisms of Scutellaria barbata D. Don on CL1-5 lung cancer cells. (2017) Oncotarget. 8:109340-109357 doi: 10.18632/oncotarget.22677
  19. Yeh CJ, Chen CC (co-first), Leu YL, Lin MW, Chiu MM, Wang SH. The effects of artocarpin on wound healing: in vitro and in vivo studies. (2017) Scientific reports; 7(1):15599. doi: 10.1038/s41598-017-15876-7
  20. Wang TH, Chen CC, Liang KH, Chen CY, Chuang WY, Ueng SH, Chu PH, Huang CG, Chen TC, Hsueh C. A Multivariate Evaluation of Factors Affecting the Quality of Freshly Frozen Tissue Specimens. (2017) Biopreservation and Biobanking,15(4):344-349
  21. Chen CC, Liang CJ, Leu YL, Chen YL, Wang SH. Viscolin Inhibits In Vitro Smooth Muscle Cell Proliferation and Migration and Neointimal Hyperplasia In Vivo. (2016) PLoS one 11(12): e0168092. doi:10.1371/journal.pone.0168092
  22. Chen CC, Lin MW, Liang CJ, Wang SH. The Anti-Inflammatory Effects and Mechanisms of Eupafolin in Lipopolysaccharide-Induced Inflammatory Responses in RAW264.7 Macrophages. (2016) PLoS One. 11(7):e0158662. doi: 10.1371/journal.pone.0158662
  23. Wang SH, Lin PY, Chiu YC, Huang JS, Kuo YT, Wu JC, Chen CC*. Curcumin-Mediated HDAC Inhibition Suppresses the DNA Damage Response and Contributes to Increased DNA Damage Sensitivity. (2015) PLoS One. 10(7):e0134110. doi: 10.1371/journal.pone.0134110
  24. Hu Z, Chen K, Xia Z, Chavez M, Pal S, Seol JH, Chen CC, Li W, Tyler JK. Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging. (2014) Genes & Development, 15;28(4):396-408 DOI: 10.1101/gad.233221.113
  25. Chen, C-C. & Tyler, J. K. Selective sensitization of cancer cells to DNA damage by a HAT inhibitor. (2009) Cell Cycle 8(18).
  26. Chen, C-C. & Tyler, J. K. Chromatin assembly signals the end of repair. (2008) Cell Cycle, 7, 3792-7.
  27. Chen, C-C., Carson, J., Feser, J., Tamburini, B., Zabaronick, S., Linger, J. & Tyler, J. K. Acetylation of lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of double-strand DNA repair. (2008) Cell, 134, 231-43. OI: 10.1016/j.cell.2008.06.035