91猫先生

研究室资料

研究室：生物分子结构暨药物开发研究室

實驗室介紹連結 (Laboratory Introduction Link) : 

研究室成員 : 碩士班研究生 1人

研究主题

我们的实验室致力於探究生物分子（包括核酸与蛋白质）的结构精细特性，以推动药物开发。透过整合结构生物学、生物化学、生物物理与细胞层级的研究方法，我们旨在揭示疾病相关靶点的作用机制，并开发精準的药物候选分子。

我们的研究聚焦於致病性核酸与蛋白质，以及它们与小分子之间的相互作用，期望应用於癌症与神经疾病的转译医学研究。

目前实验室的研究方向包括：

1. 非典型核酸结构与功能
2. 核苷酸重复扩增相关疾病
3. 天然产物啟发的核酸配体
4. 顿狈础修復调节剂与精準肿瘤治疗

论文着作

1. Roshan Satange, and Ming-Hon Hou; The role of water in mediating DNA structures with epigenetic modifications, higher-order conformations and drug-DNA interactions, RSC Chemical Biology, 6, 14 March 2025, 699-720. (https://doi.org/10.1039/D4CB00308J)

2. Chih-Chun Chang, Hsin-Ju Li, Roshan Satange, Shan-Meng Lin, Tai-Lin Chen, Chi-Chien Lin, Stephen Neidle, and Ming-Hon Hou; Structural and functional insights into targeting GCCG sites in the EGFR promoter by two DNA intercalators to inhibit breast cancer metastasis, Journal of Medicinal Chemistry, 68, 6, 03 March 2025, 6601–6615. (https://doi.org/10.1021/acs.jmedchem.4c03203)

3. Sankar Panthi, Jhen-Yi Hong, Roshan Satange, Ching-Ching Yu, Long-Yuan Li, and Ming-Hon Hou; Antiviral drug development by targeting RNA binding site, oligomerization and nuclear export of influenza nucleoprotein, International Journal of Biological Macromolecules, volume 282, Part 4, 136996, December 2024. (https://doi.org/10.1016/j.ijbiomac.2024.136996)

4. Shih-Chun Huang, Chia-Wei Chen, Roshan Satange, Chang-Chih Hsieh, Chih-Chun Chang, Shun-Ching Wang, Chi-Li Peng, Tai-Lin Chen, Ming-Hsi Chiang, Yih-Chern Horng and Ming-Hon Hou; Targeting DNA junction sites by bis-intercalators induces topological changes with potent antitumor effects, Nucleic Acids Research, volume 52, issue 15, 27, 27 August 2024, 9303–9316. (https://doi.org/10.1093/nar/gkae643)

5. Shan-Meng Lin, Hsiang-Ti Huang, Pei-Ju Fang, Chi-Fon Chang, Roshan Satange, Chung-ke Chang, Shan-Ho Chou, Stephen Neidle and Ming-Hon Hou; Structural basis of water-mediated cis Watson-Crick/Hoogsteen base-pair formation in non-CpG methylation, Nucleic Acids Research, volume 52, issue 14, 12 August 2024, 8566–8579. (https://doi.org/10.1093/nar/gkae594)

6. Shun-Ching Wang, Yi-Tsao Chen, Roshan Satange, Jhih-Wei Chu, and Ming-Hon Hou; Structural basis for water modulating RNA duplex formation in the CUG repeats of myotonic dystrophy type 1, Journal of Biological Chemistry, volume 299, issue 7,104864, 26 May 2023. (https://doi.org/10.1016/j.jbc.2023.104864)

7. Roshan Satange, Chih-Chun Chang, Long‐Yuan Li, Sheng-Hao Lin, Stephen Neidle, and Ming Hon Hou; Synergistic binding of actinomycin D and echinomycin to DNA mismatch sites and their combined anti-tumour effects, Nucleic Acids Research, volume 51, issue 8, 8 May 2023, 3540–3555. (https://doi.org/10.1093/nar/gkad156)

8. Roshan Satange, Peng Jin, Ming-Hon Hou and Ambadas B. Rode; Editorial: Non-canonical nucleic acid structures, functions and their applications for understanding human genetic diseases, Frontiers in Genetics, volume 14, 5 April 2023, 1188978. (https://doi.org/10.3389/fgene.2023.1188978)

9. Roshan Satange, Ambadas B. Rode, and Ming Hon Hou; Revisiting recent unusual drug-DNA complex structures: implications for cancer and neurological disease diagnostics and therapeutics, Bioorganic & Medicinal Chemistry, volume 76, 15 December 2022, 117094. (https://doi.org/10.1016/j.bmc.2022.117094)

10.Roshan Satange, Shih-Hao Kao, Ching-Ming Chien, Shan-Ho Chou, Chi-Chien Lin, Stephen Neidle, and Ming-Hon Hou; Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism, Nucleic Acids Research, volume 50, issue 15, 26 August 2022, 8867-8881. (https://doi.org/10.1093/nar/gkac629)

11.Cyong-Ru Jhan*, Roshan Satange, Shun-Ching Wang, Jing-Yi Zeng, Yih-Chern Horng, Peng Jin, Stephen Neidle, and Ming-Hon Hou; Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction, Nucleic Acids Research, volume 49, issue 16, 20 September 2021, 9526-9538. (https://doi.org/10.1093/nar/gkab227)

12.Chung-ke Chang, Shan-Meng Lin, Roshan Satange, Shih-Chao Lin, Sin-Cih Sun, Hung-Yi Wu, Kylene Kehn-Hall and Ming-Hon Hou; Targeting protein-protein interaction interfaces in COVID-19 drug discovery, Computational and Structural Biotechnology Journal, volume 19, 24 April 2021, 2246-2255. (https://doi.org/10.1016/j.csbj.2021.04.003)

13.Ching-Ming Chien, Pei-Ching Wu, Roshan Satange, Cheng-Chun Chang, Zi-Lun Lai, Lauren D. Hagler, Steven C. Zimmerman, and Ming-Hon Hou; Structural basis for targeting T:T mismatch with triaminotriazine-acridine conjugate induces a U-shaped head-to-head four-way junction in CTG repeat DNA, Journal of the American Chemical Society, volume 142 (25), 1 June 2020, 11165-11172. (https://doi.org/10.1021/jacs.0c03591)

14.Roshan Satange, Chien-Ying Chuang, Stephen Neidle, and Ming-Hon Hou; Polymorphic G:G mismatches act as hotspots for inducing right-handed Z DNA by DNA intercalation. Nucleic Acids Research, volume 47, issue 16, 19 September 2019, 8899-8912. (https://doi.org/10.1093/nar/gkz653)

15.Yu-Wen Chen, Roshan Satange, Pei-Ching Wu, Cyong-Ru Jhan, Chung-ke Chang, Kuang-Ren Chung, Michael J. Waring, Sheng-Wei Lin, Li-Ching Hsieh, and Ming-Hon Hou; CoII(Chromomycin)2 complex induces a conformational change of CCG repeats from i-Motif to base extruded DNA duplex. International Journal of Molecular Sciences, 19(9), 17 September 2018, 2796. (https://doi.org/10.3390/ijms19092796)

16.Roshan Satange, Chung-ke Chang, and Ming-Hon Hou; A survey of recent unusual high-resolution DNA structures provoked by mismatches, repeats and ligand binding. Nucleic Acids Research, volume 46, issue 13, 27 July 2018, 6416-6434. (https://doi.org/10.1093/nar/gky561)

17.Ming-Hon Hou, Roshan Satange, and Chung-Ke Chang; Binding of Small Molecules to Trinucleotide DNA Repeats Associated with Neurodegenerative Diseases, Chemical Biology No. 7, DNA-targeting Molecules as Therapeutic Agents, The Royal Society of Chemistry, Chapter 6, 08 Mar 2018, 144-174. (https://doi.org/10.1039/9781788012928-00144)