91猫先生

研究主题

药剂学研究在日本是属於医疗药学领域，在欧美国家则属药厂研发实务，其精神在於以既定药物赋予全新设计的处方、添加物或材料，以使药物本身之药理活性最大化或使其毒性及副作用最小化，或是延长药物於体内的留存时间。其意义在於使临床上的用药更加安全及有效，进而改善病患之依顺性。药剂学在药学研究领域内被视為较下游之药物研发过程，為一门应用科学，本研究室的主要工作便是為药物设计新的处方内容并探究其改善传统剂型缺点之程度与能力。

最近之研究计画:

1. 多功能药物奈米载体经由 retinol-binding protein 4 (RBP4) 传输至肾臟以治疗抗药性菌血症诱发之肾损伤
2. 多效能之蓝莓活性成分 pterostilbene 可塑性奈米微脂体：用以促进瓦解 P. acnes 生物膜结构与抗局部感染活性
3. 接合 NIMP-R14 抗体的脂质奈米载体主动标靶至嗜中性白血球以改善 PDE4 抑制剂之抗乾癣活性
4. 兼具被动与主动标靶能力之奈米载体传输 ciprofloxacin 以治疗感染性肺炎：以 IsaB DNA 為配体之非离子微胞
5. 设计合成含有角鯊烯之前驱药及其奈米载体开发：以毛囊為标靶位置
6. 厚朴有效成分之抗发炎及经皮吸收之研究
7. 牛樟芝萃取物治疗异位性皮肤炎之研究：牛樟芝单苯环类化合物在角质细胞中的抗发炎机制
8. 一系列合成异黄酮类化合物之经皮吸收参数建立与其乾癣治疗之活性探究
9. 中草药多酚成分之最适分离技术开发

最近之产学合作计画:

1. 中部科学园区管理局: 新剂型、新给药方式之痤疮 (Acne vulgaris) 用药-美诺四环 (Minocycline)-505(b)2新药开发
2. 台塑生医: 保养品暨美容仪器经皮吸收及功效性研究
3. 肌活丽学创研所: 乳铁蛋白抗白髮胜肽经皮吸收
4. 大江生医: LipoMask 之经皮吸收能力评估
5. 生达化学製药: VD-T03 处方优化与物理化学性质评估
6. 信东製药: 硬镜去蛋白试验
7. 元太科技: 新型药物贴片平台经皮肤传导能力可行性
8. 药华医药：碍齿-01牛皮癣软膏之药物穿透研究
9. 恩扬生物科技：牛樟芝萃取物应用於治疗乾癣及异位性皮肤炎之抗发炎

专利

1. Fluorescent dye compositions and uses thereof, Chia-Yu Fang, Chih-Jen Wen, US9,855,346 B2, 美国, 2014/11/06-2034/11/06
2. 使用2,4-二甲氧基-6-甲基苯-1,3-二醇来治疗异位性皮肤炎，王东弘、方嘉佑、杨世骏、黄泽宏，I670055，中华民国 2019/9/1-2038/4/10
3. 使用2,4-二甲氧基-6-甲基苯-1,3-二醇来防止和/或抑制葡萄球菌属物种的生长以及生物膜形成，王东弘、方嘉佑、杨世骏、黄泽宏，I680756，中华民国 2020/1/1-2038/7/1
4. 使用2,4-二甲氧基-6-甲基苯-1,3-二醇来预防和/或治疗乾癣，王东弘、方嘉佑、杨世骏、庄士亿、黄泽宏，I716940，中华民国 2021/1/21-2039/7/22
5. 凝膠型防曬組成物，吳智元、楊世駿、王東弘、方嘉佑，1760745，中华民国20224/11-2040/5/11

荣誉事蹟

实验室成员与活动照片

论文着作

The selected publications from total 339 articles

*, corresponding author

1. Tsai, M.J., Lin, C.Y., Trousil, J., Sung, C.T., Lee, M.H., Fang, J.Y.*, Yang, S.C. (2023) Proteinase K/retinoic acid-loaded cationic liposomes as multifunctional anti-acne therapy to disorganize biofilm and regulate keratinocyte proliferation. Int. J. Nanomed., 18, 3879?3896.
2. Yang, S.C., Lin, C.F., Alshetaili, A., Aljuffalin, I.A., Chien, M.Y., Fang, J.Y.* (2023) Dual antibacterial and regenerative activities of platelet-rich plasma combined with β-lactam antibiotics are effective to treat MRSA-infected skin wound: the cell- and animal-based studies. Biomed. Pharmacother., 165, 115017.
3. Huang, T.H., Chen, C.J., Lin, H.C.A., Chen, C.H., Fang, J.Y.* (2023) Self-nanoemulsifying drug delivery system-containing the poorly absorbed drug?valsartan in post-bariatric surgery. Int. J. Nanomed., 18, 2647?2658.
4. Lin, C.Y., Yu, H.P., Chang, Y.T., Lin, Z.C., Alalaiwe, A., Hwang, T.L., Fang, J.Y.* (2023) Targeting anti-inflammatory immunonanocarriers to human and murine neutrophils via Ly6 antigen for psoriasiform dermatitis alleviation. Biomater. Sci., 11, 873–893.
5. Nirmal, G.R., Lin, Z.C., Lin, C.H., Sung, C.T., Liao, C.C., Fang, J.Y.* (2022) Polydopamine/IR820 nanoparticles as topical phototheranostics for inhibiting psoriasiform lesions through dual photothermal and photodynamic treatments. Biomater. Sci., 10, 6172–6189.
6. Lee, W.R., Chou, W.L., Lin, Z.C., Sung, C.T., Lin, C.Y., Fang, J.Y.* (2022) Laser-assisted nanocarrier delivery to achieve cutaneous siRNA targeting for attenuating psoriasiform dermatitis. J. Control. Release, 347, 590–606.
7. Tseng, C.H., Lin, C.F., Aljuffali, I.A., Huang, J.R., Yang, S.H., Fang, J.Y.* (2022) The effectiveness of synthetic methoxylated isoflavones in delivering to the skin and alleviating psoriasiform lesions via topical absorption. Int. J. Pharm., 617, 121629.
8. Lee, W.R., Hsiao, C.Y., Chang, Z.Y., Wang, P.W., Aljuffali, I.A., Lin, J.Y., Fang, J.Y.* (2022) Cutaneous delivery of cosmeceutical peptides enhanced by picosecond- and nanosecond-domain Nd:YAG lasers with quick recovery of the skin barrier function: comparison with microsecond-domain ablative lasers. Pharmaceutics, 14, 450.
9. Fang, J.Y., Huang, T.H., Chen, W.J., Aljuffali, I.A., Hsu, C.Y. (2022) Rhubarb hydroxyanthraquinones act as antiobesity agents to inhibit adipogenesis and enhance lipolysis. Biomed. Pharmacother., 146, 112497.
10. Fang, J.Y., Chou, W.L., Lin, C.F., Sung, C.T., Alalaiwe, A., Yang, S.C. (2021) Facile biofilm penetration of cationic liposomes loaded with DNase I/proteinase K to eradicate Cutibacterium acnes biofilm for treating cutaneous and catheter infections. Int. J. Nanomed., 16, 8121–8138.
11. Chuang, S.Y., Chen, C.Y., Yang, S.C., Alalaiwe, A., Lin, C.H., Fang, J.Y.* (2021) 2,4-Dimethoxy-6-methylbenzene-1,3-diol, a benzenoid from Antrodia cinnamomea, mitigates psoriasiform inflammation by suppressing MAPK/NF-κB phosphorylation and GDAP1L1/Drp1 translocation. Front. Immunol., 12, 664425.
12. Nirmal, G.R., Lin, Z.C., Tsai, M.J., Yang, S.C., Alalaiwe, A., Fang, J.Y.* (2021) Photothermal treatment by PLGA-gold nanorod-isatin nanocomplexes under near-infrared irradiation for alleviating psoriasiform hyperproliferation. J. Control. Release, 333, 487–499.
13. Lin, Z.C., Hwang, T.L., Huang, T.H., Tahara, K., Trousil, J., Fang, J.Y.* (2021) Monovalent antibody-conjugated lipid-polymer nanohybrids for active targeting to desmoglein 3 of keratinocytes to attenuate psoriasiform inflammation. Theranostics, 11, 4567–4584.
14. Liao, C.C., Yu, H.P., Yang, S.C., Alalaiwe, A., Dai, Y.S., Liu, F.C., Fang, J.Y.* (2021) Multifunctional lipid-based nanocarriers with antibacterial and anti-inflammatory activities for treating MRSA bacteremia in mice. J. Nanobiotechnol., 19, 48.
15. Elzoghby, A.O., Abdelmoneem, M.A., Hassanin, I.A., Abd Elwakil, M.M., Elnaggar, M.A., Mokhtar, S., Fang, J.Y., Elkhodairy, K.A. (2020) Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier and targeting ligand. Biomaterials, 263, 120355.
16. Tang, K.W., Lin, Z.C., Wang, P.W., Alalaiwe, A., Tseng, C.H., Fang, J.Y.* (2020) Facile skin targeting of a thalidomide analog containing benzyl chloride moiety alleviates experimental psoriasis via the suppression of MAPK/NF-κB/AP-1 phosphorylation in keratinocytes. J. Dermatol. Sci., 99, 90–99.
17. Alalaiwe, A., Lin, Y.K., Lin, C.H., Wang, P.W., Lin, J.Y., Fang, J.Y.* (2020) The absorption of polycyclic aromatic hydrocarbons into the skin to elicit cutaneous inflammation: the establishment of structure–permeation and in silico–in vitro–in vivo relationships. Chemosphere, 255, 126955.
18. Yu, H.P., Liu, F.C., Lin, C.Y., Umoro, A., Trousil, J., Hwang, T.L., Fang, J.Y.* (2020) Suppression of neutrophilic inflammation can be modulated by the droplet size of anti-inflammatory nanoemulsions. Nanomedicine, 15, 773–791.
19. Wu, C.Y.J., Chen, C.H., Lin, C.Y., Feng, L.Y., Lin, Y.C., Wei, K.C., Huang, C.Y., Fang, J.Y.*, Chen, P.Y. (2020) CCL5 of glioma-associated microglia/macrophages regulates glioma migration and invasion via calcium-dependent matrix metalloproteinase-2. Neuro-Oncology, 22, 253–266.
20. Yu, H.P., Liu, F.C., Umoro, A., Lin, Z.C., Elzoghby, A.O., Hwang, T.L., Fang, J.Y.* (2020) Oleic acid-based nanosystems for mitigating acute respiratory distress syndrome in mice through neutrophil suppression: how the particulate size affects therapeutic efficiency. J. Nanobiotechnol., 18, 25.
21. Lee, W.R., Lin, Y.K., Alalaiwe, A., Wang, P.W., Liu, P.Y., Fang, J.Y.* (2020) Fractional laser-mediated siRNA delivery for mitigating psoriasis-like lesions via IL-6 silencing. Mol. Ther.-Nucl. Acids, 19, 240–251.
22. Chen, P.Y., Wu, C.Y.J., Fang, J.H., Chen, H.C., Feng, L.Y., Huang, C.Y., Wei, K.C., Fang, J.Y.*, Lin, C.Y. (2019) Functionl change of effector tumor-infiltrating CCR5+CD38+HLA-DR+CD8+ T cells in glioma microenvironment. Front. Immunol., 10, 2395.
23. Weng, J.R., Huang, T.H., Lin, Z.C., Alalaiwe, A., Fang, J.Y.* (2019) Cutaneous delivery of [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol, an indole-3-carbinol derivative, mitigates psoriasiform lesion by blocking MAPK/NF-κB/AP-1 activation. Biomed. Pharmacother., 119, 109398.
24. Hsiao, C.Y., Yang, S.C., Alalaiwe, A., Fang, J.Y.* (2019) Laser ablation and topical drug delivery: a review of recent advances. Expert Opin. Drug Deliv., 16, 937–952.
25. Lin, C.Y., Hsu, C.Y., Elzoghby, A.O., Alalaiwe, A., Hwang, T.L., Fang, J.Y.* (2019) Oleic acid as the active agent and lipid matrix in cilomilast-loaded nanocarriers to assist PDE4 inhibition of activated neutrophils for mitigating psoriasis-like lesions. Acta Biomater., 90, 350–361.
26. Fang, J.Y., Lin, C.H., Huang, T.H., Chuang, S.Y. (2019) In vivo rodent models of type 2 diabetes and their usefulness for evaluating flavonoid bioactivity. Nutrients, 11, 530.
27. Lin, Z.C., Hsieh, P.W., Hwang, T.L., Chen, C.Y., Sung, C.T., Fang, J.Y.* (2018) Topical application of anthranilate derivatives ameliorates psoriatic inflammation in a mouse model by inhibiting keratinocyte-derived chemokine expression and neutrophil infiltration. FASEB J., 32, 6783–6795.
28. Abdelmoneem, M.A., Mahmoud, M., Zaky, A., Helmy, M.W., Sallam, M., Fang, J.Y.*, Elkhodairy, K.A., Elzoghby, A.O. (2018) Dual-targeted casein micelles as green nanomedicine for synergistic phytotherapy of hepatocellular carcinoma. J. Control. Release, 287, 78–93.
29. Elgohary, M.M., Helmy, M.W., Abdelfattah, E.Z.A., Ragab, D.M., Mortada, S.M., Fang, J.Y.*, Elzoghby, A.O. (2018) Targeting sialic acid residues on lung cancer cells by inhalable boronic acid-decorated albumin nanocomposites for combined chemo/herbal therapy. J. Control. Release, 285, 230–243.
30. Chuang, S.Y., Lin, C.H., Sung, C.T., Fang, J.Y.* (2018) Murine models of psoriasis and their usefulness for drug discovery. Expert Opin. Drug Discov., 13, 551–562.
31. Liu, F.C., Yu, H.P., Lin, C.Y., Elzoghby, A.O., Hwang, T.L., Fang, J.Y.* (2018) Use of cilomilast-loaded phosphatiosomes to suppress neutrophilic inflammation for attenuating acute lung injury: the effect of nanovesicular surface charge. J. Nanobiotechnol., 16, 35.
32. Hsu, C.Y., Sung, C.T., Aljuffali, I.A., Chen, C.H., Hu, K.Y., Fang, J.Y.* (2018) Intravenous anti-MRSA phosphatiosomes mediate enhanced affinity to pulmonary surfactants for effective treatment of infectious pneumonia. Nanomed.-Nanotechnol. Biol. Med., 14, 215-225.
33. Liu, K.S., Huang, T.H., Aljuffali, I.A., Chen, E.L., Wang, J.J., Fang, J.Y.* (2017) Exploring the structure-permeation relationship of topical tricyclic antidepressants used for skin analgesia. Int. J. Pharm., 523, 386–397.
34. Hsieh, P.W., Hung, C.F., Lin, C.H., Huang, C.W., Fang, J.Y.* (2017) Anti-melasma codrug of retinoic acid assists cutaneous absorption with attenuated skin irritation. Eur. J. Pharm. Biopharm., 114, 154–163.