黄玄赢
职称: 教授
现职: 高雄长庚纪念医院解剖病理科教授级主治医师
电话: 07-731-7123
学歷: 高雄医学院医学系
专长领域: 骨骼与软组织病理、分子病理、头颈部肿瘤病理
经歷
2026–present Adjunct Professor of Pathology, College of Medicine, 91猫先生
2011–2029 Board Director, Supervisor, Executive Board Director, and Executive Supervisor, Taiwan Society of Pathology
2023–2026 Chair, Department of Anatomic Pathology, Kaohsiung Chang Gung Memorial Hospital
2012–present Adjunct Professor of Pathology, College of Medicine, 91猫先生
2019–present Editorial Board Member, Human Pathology (SCI)
2013–present Executive Board Director, Taiwan Society of Pathology
2004–present Consultant and Convener for Bone and Soft Tissue Pathology, Health Promotion Administration, Ministry of Health and Welfare
1999–present Attending Pathologist, Department of Anatomic Pathology, Kaohsiung Chang Gung Memorial Hospital
2010–2017 Chair, Department of Anatomic Pathology, Kaohsiung Chang Gung Memorial Hospital
2011, 2013, and 2021
Co-convener of the 7th (Taipei, Taiwan), 8th (Busan, Korea),
and 12th (Okayama, Japan) Asia-Pacific IAP congress,
bone and
soft tissue session
2012–2020 Member, Molecular Pathology Education Committee, Taiwan Society of Pathology
2008–2009, 2011–2012, 2014, and 2017 Review Panel Member for Anatomy, Forensic Medicine, and Pathology, National Science and Technology Council
2009–2011 Full-time Associate Professor of Pathology, College of Medicine, 91猫先生
2006–2009 Full-time Assistant Professor of Pathology, College of Medicine, 91猫先生
2004–2006 Adjunct Assistant Professor of Pathology, Shu-Zen Junior College of Medicine and Management
2001–2003 Fellow in Bone and Soft Tissue Pathology, Memorial Sloan Kettering Cancer Center, USA
1995–1999 Resident, Department of Pathology, Kaohsiung Chang Gung Memorial Hospital
1995 Resident, Department of Neurology, Kaohsiung Medical University Hospital
学会与认证
台湾病理学会
United States and Candian Academy of Pathology
International Society of Bone and Soft tissue Pathology
研究计画(近叁年)
国科会 :
1.Oncogenic mechanisms, clinicopathologic significance, and therapeutic relevance of SHOX2 overexpression in myxofibrosarcoma through novel protein interactions: elucidating a coordinated network involving ERK activation, USP11-mediated deubiquitination, and EZH2-driven gene repression (114-2320-B-182A-010-MY3, 2025/8/1–2028/7/31)
2.Molecular mechanisms and clinicopathologic implications of the thiamine transporter SLC19A2 as a tumor suppressor in myxofibrosarcoma: novel functional roles in anti-angiogenesis, suppression of invasiveness, and mitochondria-related metabolic reprogramming (111-2320-B-182A-006-MY3, 2022/8/1–2025/7/31)
长庚研究计画:
1. Integrative transcriptomic and epigenetic analyses of differences and similarities between bona fide kinase fusions and wild-type kinase upregulation in fusion-driven sarcomas (CMRPG8Q0821)
2. Integrated analyses of transcriptomic expression, whole-exome sequencing, and methylomics to identify molecular determinants of prognosis in solitary fibrous tumors beyond WHO-defined risk stratification (CMRPG8P0821)
3. Transcriptomic and methylomic characterization of mesenchymal tumors resembling RB1-deficient fibrofatty tumors but harboring PLAG1/HMGA2 fusions: determining whether they represent a distinct novel tumor entity or genetic variants of existing tumor types (CMRPG8N0891)
4. Comprehensive molecular characterization of SH3PXD2A::HTRA1 gene fusions across peripheral nerve sheath tumors: diagnostic value in a distinctive schwannoma subset, clinicopathologic correlations, and potential biological and pathogenetic implications (CMRPG8M1201, CMRPG8M1202)
厂商赞助研究计画 :
1.结合Pan-TRK免疫组织化学筛选与融合激?限定之RNA测序用以检测纺锤形间质肿瘤、炎性肌纤维母细胞肿瘤、和胆管癌中NTRK或功能类似的激融合()
2.笔补苍-罢搁碍阳性胃肠道间质瘤各种潜在致病畸变之研究:强调肠道和再发病例(, XPRPG8N0132)
论文发表(2021–2026)
1.Wang JC, Li WS*, Kao YC, Lee JC, Lee PH, Huang SC, Tsai JW, Chen CC, Chang CD, Yu SC, Huang HY*. Clinicopathologic and molecular characterization of USP6-rearranged soft tissue neoplasms: The evidence of genetic relatedness indicates an expanding family with variable bone-forming capacity. Histopathology. 2021 April:78.676-689 (SCI 2023 IF: 3.9, rank: 17/88 =19.3 % in Pathology, co-corresponding author)
2. Li CF, Chan TC, Wang CI, Fang FM, Lin PC, Yu SC, Huang HY*. RSF1 requires CEBP/ β and hSNF2H to promote IL-1β-mediated angiogenesis: The clinical and therapeutic relevance of RSF1 overexpression and amplification in myxofibrosarcomas. Angiogenesis. 2021 Aug;24(3):533-548 (Corresponding author, SCI 2023 IF=9.2, rank: 3/96=3.1% in Peripheral Vascular Disease)
3. Infant malignant ectomesenchymoma masquerading as inguinal hernia in two patients. Pediatr Neonatol. 021 May;62(3):324-326. (SCI 2023 IF=2.3, rank: 53/186=28.5% in Pediatrics)
4. Lee JC*, Li WS, Kao YC, Chung YC, Huang HY*. Toward a unifying entity that encompasses most, but perhaps not all, inflammatory leiomyosarcomas and histiocyte-rich rhabdomyoblastic tumors. Mod Pathol 2021 Jul;34(7):1434-1438 (co-corresponding author)(SCI,2023 IF: 7.1, rank: 5/88=5.7 % in Pathology)
5. Dynamic contrast-enhanced magnetic resonance imaging in correlation with tongue cancer stages. Acta Radiol. 2021 Dec;62(12):1618-1624. (SCI,2023 IF: 1.1, rank: 153/204 =75.0 % in Radiology,Nuclear Medicine &Medical Imaging)
6. S100P as a marker for poor survival and advanced stage in gallbladder carcinoma. Ann Diagn Pathol. 2021 Mar 22;52:151736. doi: 10.1016/j.anndiagpath.2021.151736. (SCI,2023 IF: 1.5, rank: 56/88 =63.6% in Pathology)
7. Ossifying low grade endometrial stromal sarcoma with PHF1-BRD8 fusion. Cancer Genet. 2021 Apr 22;256-257:81-85. (SCI,2023 IF: 1.4, rank: 152/191=79.6% in Genetics & Heredity)
8. Kao YC, PH Lee, Wu CL, Yu SC, Huang HY*. Superficial ALK-rearranged myxoid spindle cell neoplasm with a novel FMR1-ALK fusion gene. Mod Pathol. 2021 Mar;35(3):438-441 (corresponding author,2023 IF: 7.1, rank: 5/88 =5.7 % in Pathology).
9. Chen CH, Chang KC, Chuang CH, Huang HY*. The emerging PRRX1-NCOA fibroblastic neoplasm: A combined reappraisal of published tumors and two new cases. Virchows Arch. 2021 (corresponding author, SCI,2023 IF:3.4, rank, 22/88=25.0% in Pathology)
10. Liang CW, Fang PW, Huang HY, Lo CM. Deep convolutional neural networks detect tumor genotype from pathological tissue images in gastrointestinal stromal tumors. Cancers 2021 in press (SCI, 2023 IF:4.5, rank, 78/322=24.2% in oncology).
11. Lee PH, Kao YC, Hsieh TH, Liao JB, Li CF, Lee JC, Chang YM, Chang CD, Huang SC, Chen TZ, Liu TT, Yu SC, Huang HY*. Myoepithelial and oral intracranial myxoid mesenchymal tumor-like neoplasms as diagnostic considerations of the ever-expanding extracranial myxocollagenous tumors harboring FET-CREB fusions. Pathol Res Pract 2021, Nov in press (corresponding author, (SCI,2023 IF:2.9, rank, 28/88=31.8% in Pathology)
12. Lee PH#, Huang SC#, Wu PS^, Tai HC^, Lee CH, Lee JC, Kao YC, Tsai JW, Hsieh TH, Li CF, Li WS, Liu TT, Su YL, Yu SC, Huang HY*. Molecular characterization of dermatofibrosarcoma protuberans: the clinicopathologic significance of uncommon fusion gene rearrangements and their diagnostic importance in the exclusively subcutaneous and circumscribed lesions. Am J Surg Pathol. 2022 Jul 1;46(7):942-955. (Corresponding author,( SCI,2023 IF:4.5, rank, 19/290=6.6 % in Surgery)
13. Tsai JW§, Lee JC§, Hsieh TH, Huang SC, Lee PH, Liu TT, Kao YC, Chang CD, Weng TF, Li CF, Lin JC, Liang CW, Su YL, Chang IYF, Wang YT, Chang NY, Yu SC, Wang JC, Huang HY*. Adult NTRK-rearranged spindle cell neoplasms of the viscera: with an emphasis on rare locations and heterologous elements. Mod Pathol. 2022 July; (35):911–921. (Corresponding author,SCI,2023 IF: 7.1, rank: 5/88 =5.7 % in Pathology).
14. Malignant gastrointestinal neuroectodermal tumor in head and neck: two challenging cases with diverse morphology and different considerations for differential diagnosis. Virchows Arch. 2022 Jan 18. doi: 10.1007/s00428-022-03274-y. (SCI,2023 IF:3.4, rank, 22/88=25.0% in Pathology)
15. Pulmonary "Inflammatory Leiomyosarcomas" Are Indolent Tumors With Diploid Genomes and No Convincing Rhabdomyoblastic Differentiation.Am J Surg Pathol. 2022 Mar 1;46(3):424-433. (Corresponding author, SCI,2023 IF:4.5, rank, 19/290=6.6 % in Surgery)
16. Liu TT, Chien-Feng Li CF, Tan KT, Jan YH, Lee PH, Huang CH, Yu SC, Tsao CF, Wang JC, Huang HY* Characterization of aberrations in DNA damage repair pathways in gastrointestinal stromal tumors: the clinicopathologic relevance of γH2AX and 53BP1 in correlation with heterozygous deletions of CHEK2, BRCA2, and RB1. Cancers (Basel). 2022 Mar 31;14(7):1787. doi: 10.3390/cancers14071787. (SCI, 2023 IF:4.5, rank, 78/222=24.2% in oncology).
17. Sublingual clear cell carcinoma with liver metastasis: A case report and literature review. Kaohsiung J Med Sci. 2022 Jun 15. doi: 10.1002/kjm2.12567. (SCI, 2023 IF:2.7, rank, 95/189=50.3% in Medicine, General & Internal).
18. A clinicopathological reappraisal of orbital vascular malformations and distinctive GJA4 mutation in cavernous venous malformations. Hum Pathol. 2022 Oct 6:S0046-8177(22)00241-6. doi: 10.1016/j.humpath.2022.10.002. (SCI, 2023 IF:2.7, rank, 31/88=35.2% in Pathology).
19. Chang Chien YC, Madarász K, Csoma SL, Mótyán JA, Huang HY, Méhes G, Mokánszki A. Molecular Identification and In Silico Protein Analysis of a Novel BCOR-CLGN Gene Fusion in Intrathoracic BCOR-Rearranged Sarcoma. Cancers (Basel). 2023 Jan 31;15(3):898. (SCI, 2023 IF:4.5, rank, 78/322=24.2% in Oncology).
20. Huang SC, Chang IYF, Chang CJ, Liu H, Chen KH, Liu TT, Hsieh TY, Chuang HC, Chien-Cheng Chen, Lin IC, Ng KF, Huang HY*, Chen TC*. Association between hepatic angiosarcoma and end-stage renal disease: nationwide population-based evidence and enriched mutational signature of aristolochic acid exposure. J Pathol. 2023 June;260(2):165–176 (co-corresponding authors, SCI in press, (SCI, 2023 IF:5.6, rank, 8/88=9.1% in Pathology).
21. Kao YC, Yoshida A, Hsieh TH, Nord KH, Saba KH, Ichikawa H, Tsai JW, Huang HY, Chih-Hsueh Chen P, Fletcher CDM, Lee JC. Identification of COL1A1/2 Mutations and Fusions With Noncoding RNA Genes in Bizarre Parosteal Osteochondromatous Proliferation (Nora Lesion). Mod Pathol. 2023 Feb;36(2):100011 (SCI, 2023 IF: 7.1, rank: 5/88 =5.7 % in Pathology).
22. Huang SC, Lee JC, Hsu YC, Tsai JW, Kao YC, Hsieh TH, Chang YM, Chang KC, Wu PS, Chen CH, Chang CD, Lee PH, Tai HC, Liu TT, Wen MC, Li WS, Yu SC, Wang JC, Huang HY*. Extraskeletal myxoid chondrosarcomas: the uncommon clinicopathologic manifestations and significance of TAF15::NR4A3 fusion in 58 molecularly confirmed cases. Mod Pathol. 2023 Jul;36(7):100161. (Corresponding author, SCI, 2023 IF: 7.1, rank: 5/88 =5.7 % in Pathology).
23. Li CF, Chan TC, Fang FM, Yu SC, Huang HY.* PAK1
overexpression promotes myxofibrosarcoma angiogenesis through
STAT5B-mediated CSF2 transactivation:
clinical and therapeutic relevance of amplification and nuclear entry. Int J Biol
Sci. 2023 Jul 31;19(12):3920-3936. (Corresponding author,SCI, 2023 IF:8.2, rank: 31/313 =9.9 % in
Biochemistry &
Molecular Biology).
24. Lee JC, Hsieh TH, Kao YC, Tsai CF, Huang HY, Shih CY, Song HL, Oda Y, Chen PC, Pan CC, Sittampalam K, Petersson F, Konishi E, Chiu WY, Chen CF, Carpenter TO, Lu TP, Chang CD, Huang SC, Folpe AL. Klotho overexpression is frequently associated with upstream rearrangements in fusion-negative phosphaturic mesenchymal tumors of bone and sinonasal tract. Mod Pathol. 2023 Sep 22:100336. doi:10.1016/j.modpat.2023.100336.( SCI, 2023 IF: 7.1, rank: 5/88 =5.7 % in Pathology.)
25. EWSR1::POU2AF3(COLCA2) Sarcoma: An aggressive, polyphenotypic sarcoma with a head and neck predilection. Mod Pathol. 2023 Sep 22:100337. doi: 10.1016/j.modpat.2023.100337. (SCI, 2023 IF:7.1, rank: 5/88 =5.7 % in Pathology.)
26. Wang SH, Huang HY, Medeiros LJ, Chang KC. ALK-positive histiocytosis of external auditory canal in a 3-year-old boy. Am J Hematol. 2023 Oct 26. doi: 10.1002/ajh.27143. Online ahead of print. (SCI, 2023 IF: 10.1, rank: 8/97 =8.2 % in Hematology.)
27. Huang HY, Lo CM, Lu HI, Chang JP. Huge ancient schwannoma causing acute respiratory failure: a case report. J Cardiothorac Surg. 2024 Mar 15;19(1):131. (SCI, 2023 IF: 1.5, rank: 153/290 =52.8 % in Surgery.)
28. Lee JC#, Lee PH#, Li SC^,, Liao KC^, Chang YM, Chen HC, Kao YC, Wu PS, Huang SC, Tsai JW, Hu CF, Li CH, Liu TT, Yu SC, Wang JC, Huang HY*. Systematic characterization of the clinical and pathological features of schwannomas harboring SH3PXD2A::HTRA1 fusion. Mod Pathol. 2024 Mar;37(3):100427. (Corresponding author, (SCI, 2023 IF: 7.1, rank: 5/88 =5.7 % in Pathology;) #, co-first authors, ^, equal contribution).
29. Lee PH, Huang SC, Lee JC, Li SC, JTsai JW, Chang YM, Kao YC, Wen-Lang Fan WL, Chang CD, Chen HC, Li CH, Hu CF, Liu TT, Wu PS, Nam MH, Yu SC, Wang JC, Huang HY*. In-frame insertions of SOX10 are highly enriched and characterize a distinct transcriptomic profile in gastrointestinal schwannomas. J Pathol. 2025 March. (Corresponding author, SCI in press, (SCI, 2023 IF:5.6, rank, 8/88=9.1% in Pathology).
30. Huang SN, Kao YC, Lee JC, Huang HY, Chang C, Li WS, Hsieh TH, Nam MH. Pseudomyogenic hemangioendothelioma: A series of 13 patients, highlighting unusual cardiac locations, novel gene fusions, and malignant behavior. Pathol Res Pract. 2025 Nov;275:156254. (SCI, 2024 IF: 3.2, rank: 24/90 =5.7 % in Pathology)
31. Chou CC, Lee JC, Wu PS, Kao YC, Chang YM, Huang SC, Hsu YC, Pan CC, Hang JF, Liang PI, Tsai JW, Lee PH, Li CH, Hu CF, Yu SC, Huang HY. Genitourinary Mesenchymal Neoplasms with Tumor-Defining Genetic Alterations: A Clinicopathologic and Molecular Correlative Study of 71 cases. Hum Pathol. 2025 Oct 21:105953. (corresponding author, SCI in press, 2024 IF:2.6, rank, 35/90=38.9% in Pathology).
32. Lee CH, Lee YS, Bennett JA, Kolin DL, Lee JC, Huang HY, K?bel M, Sementsov M, Dickson BC, Koelsche C, Kommoss F, von Deimling A, Kommoss FKF. GREB1-rearranged uterine tumour shares a common DNA methylation signature with ESR1-rearranged UTROSCT. Histopathology. 2026 Apr;88(5):1084-1093. (SCI 2025 IF: 3.8, rank: 19/90 =21.1 % in Pathology)
33. Hu CF, Huang HY, Li WS, Lee CH. Primary pulmonary composite hemangioendothelioma harboring a YAP1::FOXR1 fusion. Pathology (SCI in press, 2025 IF: 3.9, rank: 17/90 =18.9 % in Pathology)
获奖奖项
2014年 國家生技醫療品質獎銅獎-解构复杂罕见的肿瘤群-领航结缔组织病理
2010年 台湾病理学会-叶曙基金会最佳论文奖
2009年 行政院国科会吳大猷先生紀念獎