2025 國際先進放射醫學論壇 Series 1
我們誠摯邀請您參與本年度第一場國際論壇，本次特別榮幸邀請到來自 美國德州大學西南醫學中心 的 Kang-Hsin Wang 博士，分享他在小動物光學影像與 Flash 放射治療 領域的前沿研究成果。
? 活動時間：2025 年 6月11日 中午12:10-13:00
? 活動地點：大教室 (線上演講)
? 線上會議網址:
?? 主題演講：
"Assessing the Flash Effect in Minimizing Radiation-induced Late Toxicity and Advancing Novel Optical Imaging for Cancer Research"
专题演讲介绍:
本次专题演讲将聚焦於癌症治疗领域中两项具突破性的创新技术，致力推动更安全且高效的放射治疗方法，并实现更精準的癌症早期侦测。演讲首先介绍最新的超高剂量率放射治疗技术（贵尝础厂贬-搁罢）。传统放疗在针对復发性脊椎转移癌进行重复照射时，常因正常组织的毒性反应而受限。贵尝础厂贬-搁罢因其潜在显着降低副作用的特性，备受期待，但其对晚期反应组织的影响仍有待釐清。演讲将分享美国德州大学西南医学中心关於贵尝础厂贬脊髓照射的前沿研究成果，涵盖高精度贵尝础厂贬系统的开发、动物模型中脊髓耐受性的评估，以及探讨贵尝础厂贬对脊髓微血管保护机制的物理化学模型。这些研究成果将助力推动贵尝础厂贬-搁罢於临床上的安全应用，特别是在脊椎转移癌的治疗领域。
接着，演讲将介绍本研究室目前积极发展的多项先进高灵敏度光学影像技术，包括叁维生物发光断层扫描、单像素成像及萤光寿命成像。这些技术能够精準呈现肿瘤的动态变化及其微环境特性，广泛应用於早期侦测多处转移癌、辅助放射治疗的精準定位，并有效区分肿瘤与正常组织。这些创新工具将促进癌症基础研究与临床应用的深度整合，推动跨领域的合作与发展。
Innovations in radiotherapy and imaging are transforming the landscape of cancer treatment and research. In this talk, I will present 2 significant and highly innovative directions aimed at advancing both safer and effective radiation delivery and pre-clinical cancer detection.
Radiation therapy (RT) is often limited by normal tissue toxicity, particularly in re-irradiation for recurrent vertebral metastases. FLASH-RT (ultra-high dose rate) shows promise in reducing toxicity, offering a transformative approach for safer, more effective re-irradiation. However, its effects on late-responding tissues remain unclear, limiting clinical translation. The spinal cord, given its clinical relevance and well-characterized dose-response in conventional dose rate RT (CONV-RT), serves as an ideal model to assess FLASH-RT’s ability to spare late-responding tissues and its efficacy in re-irradiating spinal metastases. We will provide an overview of ongoing FLASH spinal cord studies conducted at UT Southwestern Medical Center, including the development of a high-precision FLASH platform for in vivo spinal cord irradiation, assessment of FLASH-RT’s impact on spinal cord tolerance using a rat model, and establishment of the physicochemical model elucidating mechanisms of FLASH-mediated microvascular protection in spinal cord. By integrating spinal cord toxicity assessment with robust mechanistic approaches, this proposal will generate critical insights to inform the clinical implementation of FLASH-RT, especially for spinal metastases treatment.
In addition, we will also introduce recent developments in ultrasensitive, high-contrast optical imaging technologies, including 3D bioluminescence tomography, single-pixel imaging, and fluorescence lifetime imaging. These optical techniques enable precise, visualization of tumor dynamics and microenvironment changes. Applications include early detection of multi-focal metastases in vivo, guiding preclinical radiation delivery, and distinguishing tumor boundaries from healthy tissue. These tools are designed to enhance translational studies and offer collaboration opportunities for integrative cancer research