陳怡婷/Yi-Ting Chen
职称： 教授
现职： 教授
电话： 03-2118800#3558
学歷： 国立清华大学化学所博士
专长领域： 生物质谱、蛋白体学、代谢体学、分析化学、系统生物学、泌尿道疾病
个人网页：
工作经歷
2024.8-迄今 长庚大学分子醫學研究中心, 副中心主任
2023.8-迄今 长庚大学生物醫學系, 教授
2018-2023 长庚大学生物醫學系, 副教授
2013-2018 长庚大学生物醫學系, 助理教授
2007-2013 长庚大学分子醫學研究中心，副研究員
2002-2007 工業技術研究院，研究員
2001 加拿大亞伯達大學研究助理
获奖
- 2017 台灣質譜學會青年學者研究獎
- 2018 財團法人李?榮教育基金會第八屆學術研究傑出青年教授獎
特殊成就
1. 2015.7-Present 台灣質譜學會理監事
2. 2017.11-Present 台灣蛋白體學會理事
专利
總专利數超過三十件1. 陳怡婷、余兆松、陳建綸、張玉生 (2013) 膀胱癌之生物標記及其檢測方法。中華民國专利發明第I390204號。
2. 陳怡婷、余兆松、陳建綸、張玉生 (2016) 尿液生物標記作為預測膀胱及腎臟癌的用途。中華民國专利發明第I522367號。
3. 陳怡婷、張鈺、陳建綸、張英勛、陳建綸、虞凱傑、張榮興(2023)，腎臟罹癌風險之判斷方法，中華民國专利發明第I817329號。
指導學生获奖
1. 长庚大学生物醫學所碩士班學生陳筱葳，Best poster Award (corresponding author), 2009 TPS International Proteomics Conference and 5th AUHUPO MPI workshop, June 19-20, 2009, Taipei, Taiwan. (台灣蛋白體年會)
2. 长庚大学生物醫學所碩士班學生陳筱葳，Best poster award (corresponding author), 2nd CGMH International Symposium on Disease Proteomics, June 6th, 2009, Taoyuan, Taiwan.
3. 长庚大学生物醫學所碩士班學生陳筱葳，Best poster award, 2010 Disease Biomarker and TPS International Proteomics Conference, April 23-24, 2010, Taipei, Taiwan. (台灣蛋白體年會)
4. 长庚大学生物醫學所碩士班學生賴岳汎，Best poster award , 2011 Translational Medicine Conference and Taiwan Proteomics Society Annual Symposium, April 27-28, 2011, Taipei, Taiwan. (台灣蛋白體年會)
5. 长庚大学生物醫學所碩士班學生陳筱葳，Dissertation award, Chinese Chemical Society, Dec. 3-4, 2011, Hsinchu, Taiwan. (中國化學會分析化學組研究生論文獎優等)
6. 长庚大学生物醫學所碩士班學生周孟楷，Best poster award , Taiwan Proteomics Society Annual Conference & Translational and Systems Biology Symposium. Nov. 11-12, 2014. Taipei, Taiwan. (台灣蛋白體年會)
7. 长庚大学生物醫學所碩士班學生蔡逸懷，第 16 屆台塑企業應用技術研討會，研發論文獎，學校組優勝，June 6, 2018。
8. 109年度 科技部大專學生研究計畫 (长庚大学醫學系王尉軒)
9. 109年度 科技部大專學生研究計畫 (长庚大学生醫系唐羨敏 )。
10. 110年度 科技部大專學生研究計畫 (长庚大学醫學系王尉軒)。
11. 长庚大学生醫系杜祥誠(大叁专题生)，第37屆生物醫學聯合年會，中華民國臨床生化學會壁報論文競賽壁報論文優勝獎 暨 2023年永信李天德醫藥基金會壁報論文優等獎，March 19, 2023.
12. 陳玟臻(大四專題生)，第28屆分析化學技術交流研討會，口頭報告優勝獎，成功大學，May14, 2023.
13. 陳玟臻(大四專題生)，111學年度食品與健康科技研討會 超濃縮研究短講競賽第一名，長庚科技大學，May 18, 2023.
14. 涂瑋儒(博士班研究生)，111學年度食品與健康科技研討會 超濃縮研究短講競賽第三名，長庚科技大學，May 18, 2023.
15. 112年度 科技部大專學生研究計畫 (长庚大学生醫系杜祥誠)
16. 112年度 科技部大專學生研究計畫 (长庚大学醫技系吳易昕)
17. 陳筱葳(长庚大学分醫中心助理)，2023長庚醫學週第15屆紀念王創辦人永慶先生學術研討論論文競賽，醫療學術類醫事組口頭報告-銅獎，Oct. 21, 2023。
18. 陳玟臻(五年一貫碩士班生)，2023MOPM多體學及精準醫學聯合研討會，海報競賽特優、大會優秀海報獎初選入圍，Nov.12, 2023.
19. 杜祥誠(大四專題生)，2023MOPM多體學及精準醫學聯合研討會，海報競賽特優，Nov.12, 2023.
20. 張鈺，研發論文暨海報競賽學校組優勝，台塑企業應用技術研討會，June 24, 2024.
21. 陳玟臻, Student Tavel Award, The 72nd The annual conference of the Mass Spectrometry Society of Japan (MSSJ). 第72屆日本質譜學會年會. June. 10-12, 2024. Tsukuba City, Japan.
22. 杜祥誠, Student Tavel Award, The 72nd The annual conference of the Mass Spectrometry Society of Japan (MSSJ). 第72屆日本質譜學會年會. June. 10-12, 2024. Tsukuba City, Japan.
23. 杜祥誠，國科會化學學門【大專生創作獎】?112年度大專學生研究計畫研究創作獎，July 2nd, 2024.
24. 113年度 科技部大專學生研究計畫(长庚大学醫學系麥文馨)
研究方向及研究室特色
我们实验室之研究方向為开发侦测及定量物生物分子(包括蛋白质及代谢物)之质谱技术，这些方法已经被用来研究细胞模式及临床组织及体液等真实样品，并经由国际合作保持技术的新颖性。我们的研究目标在於利用本实验室之专长(蛋白质体、代谢体及生物质谱技术)了解泌尿系统癌症之生物机制，利用体学的方法研究膀胱癌及肾臟癌细胞株、肿瘤组织及尿液，希望找寻早期诊断癌症之非侵入式生物标记。
并与泌尿科、肾臟科、妇产科、小儿科等临床医生合作，运用蛋白质体及代谢体等后基因体学研究方法，全面性的研究正常与疾病生物系统(细胞株及临床收集的体液或组织)中蛋白质与代谢物之群体变化，监测各个分子在疾病所扮演的角色，探讨恶性与良性泌尿系统疾病发生及恶化之生物机制，以期朝向临床应用及个人化医疗迈进。
目前实验室的研究方向如下 :
1. 以系统性方法找寻及验证泌尿系统癌症之生物标誌及其生物重要性
(Using a Systems Approach to Discover and Assess Urological Cancer Biomarkers)
我们研究了膀胱癌细胞株之分泌蛋白质体以及临床医生取得之肿瘤及尿液组成蛋白体，经由交叉比对，已经发现一系列可能随着癌症的发生而产生表现量改变的分子，未来将持续验证其重要性，并研究其与病理状况之相关性，了解其在泌尿系统研症所扮演之角色。
System approaches for biomarker discovery
and mechanism study of urological cancer
2. 发展标靶性及多重定量特性之MRM-MS技术在大量临床样品中验证疾病生物标誌之重要性 (Targeted and Multiplexed Quantitation of Proteins for Verification of Biomarker Panels using Multiple-Reaction-Monitoring MS (MRM-MS) and immune MRM-MS. Collaboration with Prof. Christoph Borchers, the Director of the University of Victoria Genome BC Proteomics Centre, Canada; and clinical teams in Chang Gang Memorial Hospital)
蛋白质体学是当今疾病生物标誌研究中最热门的研究领域之一。我们研究团队过去的研究成功地以iTRAQ技术分析发现膀胱癌病患尿液检体中多种蛋白质生物标誌，同时也已建立「液相层析多重反应监测质谱定量分析技术」(LC-MRM-MS)，首度完成於人类临床尿液样本中同步定量63个蛋白质分子的研究工作，此技术将可协助研究学者在大量检体中验证过去所找到的生物标记后选分子，未来将继续发展「免疫浓缩-液相层析多重反应监测质谱定量分析技术」(immuno-MRM-MS)及生物资讯分析方法，以扩展至其他疾病或不同型态的检体。
Development of MRM-MS assays for protein
biomarker verification
3. 利用标靶定量技术同时分析生物路径中之多种蛋白质及代谢物分子，以系统生物学的方法阐明疾病发生及进展过程中所参与的生物反应机制
(Development and Applications of Targeted Proteomic and Metabolomic Approaches in Cancer Biology to study Urological Oncology. Collaboration with Prof. Liang Li, Department of Chemistry, University of Alberta, Canada)
随着标靶定量技术的发展，我们开始可以利用质谱方法大规格的追踪参与特定生物反应机制之多种蛋白质及代谢分子，比较细胞模式在不同处理条件下的表现量，监测各个分子在疾病所扮演的角色，并在个人临床样品中验证，以期朝向个人化医疗迈进。论文与着作
(1) “MALDI-TOF MS”，Yi-Ting Chen、Y. C. Ling, Instruments Today, 19, 60-70, 1997.
(2) Y. C. Ling, L. Lin and Y. T. Chen, ?Quantitative Analysis of Antibiotics by Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry?, Rapid Commun. Mass Spectrometry. 12, 317-327, 1998 (SCI).
(3) Y. T. Chen and Y. C. Ling, ?An Overview of Supercritical Fluid Extraction in Chinese Herbal Medicine：from Preparation to Analysis?, Journal of Food and Drug Analysis, Special Issue on Chinese Herbal Medicines, 8, 235-247, 2000 (SCI).
(4) Y. T. Chen and Y. C. Ling, ?Detection of Water-soluble Vitamins by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry using Porphyrin Matrices?, J. Mass. Sepctrom. 37, 716-730, 2002 (SCI).
(5) Y. T Chen, C. Y. Tsao, J. M Li, C. Y. Tsai, S. F. Chiu, T. L. Tseng*, ? Large-scale Protein Identification of Human Urine Proteome by Multi-dimensional Liquid Chromatography and Tandem Mass Spectrometry ?, Proteomics Clin. Appl. 1, 577-587, 2007 (SCI).
(6) Hui-Chu Hsieh, Yi-Ting Chen, Jen-Ming Li, Ting-Yu Chou, Ming-Fong Chang, See-Chang Huang, Tzu-Ling Tseng, Chung-Cheng Liu, and Sung-Fang Chen*, “Protein Profilings in Mouse Liver Regeneration after Partial Hepatectomy using iTRAQ Technology”. J. Proteome Res. 8, 1004-1043, 2009 (SCI).
(7) Yi-Ting Chen*, Chien-Lun Chen, Hsiao-Wei Chen, Ting Chung, Chih-Ching Wu, Chi-De Chen, Chia-Wei Hsu, Meng-Chieh Chen, Ke-Hung Tsui, Phei-Lang Chang, Yu-Sun Chang, Jau-Song Yu*, ? Discovery of Novel Bladder Cancer Biomarkers by Comparative Urine Proteomics Using iTRAQ Technology ?, J. Proteome Research. 9, 5803-5815, 2010 (SCI).
(8) Shih-Yuan Chen, Yi-Ting Chen, Jey-Jau Lee, Soofin Cheng*, Tuning Pore Diameter of Platelet SBA-15 Materials for Enzyme Adsorption, J. Mater. Chem. 21, 5693-5703. 2011 (SCI).
(9) Yi-Ting Chen, Hsiao-Wei Chen, Derek Smith, Kung-Hao Liang, Ting Chung, Chien-Lun Chen, Yu-Sun Chang, Christoph Borchers,* Jau-Song Yu.* Multiplexed quantification of 63 proteins in human urine by multiple reaction monitoring-based mass spectrometry for discovery of potential bladder cancer biomarkers. J. Proteomics. 75, 3529-3545, 2012 (SCI).
(10) Yi-Ting Chen*, Fu-Shing Wang, Zhendong Li, Liang Li*, Yong-Chien Ling*. Development of a Matrix-assisted Laser Desorption Ionization Mass Spectrometric Method for Rapid Process-Monitoring of Phthalocyanine Compounds. Analytica Chimica Acta. 736, 69–77, 2012. (SCI)
(11) Chien-Lun Chen, Yue-Fan Lai,, Kun-Yi Chien, Jau-Song Yu, Hsiao-Wei Chen, Petrus Tang, Chia-Wei Hsu, Chi-De Chen, Yu-Sun Chang, Phei-Lang Chang, Yi-Ting Chen*, Comparative and Targeted Proteomic Analyses of Urinary Exosomes from Bladder Cancer and Hernia Patients. J. Proteome Research. 11, 5611?5629, 2012. (SCI)
(12) Yen-Heng Lin*, Ying-Ju Chen, Chao-Sung Lai*, Yi-Ting Chen, Chien-Lun Chen, Jau-Song Yu, and Yu-Sun Chang, A negative-pressure-driven microfluidic chip for the rapid detection of a bladder cancer biomarker in urine using bead-based enzyme-linked immunosorbent assay. Biomicrofluidics 7, 024103, 2013. (SCI)
(13) Chien-Lun Chen, Tsung-Shih, Lin, Cheng-Han, Tsai, Chih-Ching Wu, Ting Chung, Kun-Yi Chien, Maureen Wu, Yu-Sun Chang, Jau-Song Yu*, Yi-Ting Chen*, Identification of Potential Bladder Cancer Markers in Urine by Abundant-Protein Depletion Coupled with Quantitative Proteomics. J. Proteomics. 85, 28-43, 2013. (SCI)
(14) Chi-De Chen, Chih-Liang Wang, Chia-Jung Yu, Kun-Yi Chien, Yi-Ting Chen, Min-Chi Chen, Yu-Sun Chang, Chin-Ching Wu*, Jau-Song Yu*. Targeted Proteomics Pipeline Reveals Potential Biomarkers forthe Diagnosis of Metastatic Lung Cancer in Pleural Effusion. J. Proteome Research. 13(6):2818-29, 2014.
(15) Jun Peng, Yi-Ting Chen, Chien-Lun Chen and Liang Li, Development of a Universal Metabolome-Standard Method for Long-term LC-MS Metabolome Profiling and Its Application for Bladder Cancer Urine-Metabolite-Biomarker Discovery. Anal. Chem. 86(13):6540-7, 2014.
(16) Chiun-Gung Juo*, Chien-Lun Chen, Shiang-Ting Lin, Shu-Hsuan Fu, Yi-Ting Chen, Yu-Sun Chang and Jau-Song Yu. Mass accuracy improvement of ESI-RPLC-MS based urinary metabolomic analysis by post-run calibration using sodium formate cluster ions. Rapid Commun. Mass Spectrom. 28, 1813-1820, 2014.
(17) Hsiao-Chien Chen, Yi-Ting Chen, Rung-Ywan Tsai, Min-Cheng Chen, Shi-Liang Chen, Min-Cong Xiao, Chien-Lun Chen, Mu-Yi Hua*. A sensitive and selective magnetic graphene composite-modified polycrystalline-silicon nanowire field-effect transistor for bladder cancer diagnosis. Biosensors and Bioelectronics. 66, 198–207, 2015 . (Co-first author)
(18) Yi-Ting Chen, Li-Ping Tuan, Hsiao-Wei Chen, I-An Wei, Min-Yuan Chou, Han-Min Chen, Yu-Chang Tyan, Sung-Fang Chen*. Quantitative analysis of prostate specific antigen isoforms using immunoprecipitation and isotope dilution mass spectrometry. Anal. Chem. 2015, 87(1):545-53. (Co-first author)
(19) Chien-Lun Chen, Ting Chung, Chih-Ching Wu, Kwai-Fong Ng, Jau-Song Yu, Cheng-Han Tsai, Yu-Sun Chang, Ying Liang, Yi-Ting Chen*. Comparative tissue proteomics of microdissected specimens reveals novel biomarkers of bladder cancer. Mol. Cell Proteomics. 2015. 14(9), 2466-2478. (Co-first and corresponding author)
(20) Chih-Hsiang Chang, Chia-Hung Yang, Huang-Yu Yang, Tien-Hsing Chen, Chan-Yu Lin, Su-Wei Chang, Yi-Ting Chen, Cheng-Chieh Hung, Ji-Tseng Fang, Chih-Wei Yang, Yung-Chang Chen*. Urinary Biomarkers Improve the Diagnosis of Intrinsic Acute Kidney Injury in Coronary Care units. Medicine. 2015 Oct;94(40):e1703.
(21) Chih-Hsiang Chang, Pei-Chun Fan, Chan-Yu Lin, Chia-Hung Yang, Yi-Ting Chen, Su-Wei Chang, Huang-Yu Yang, Chang-Chyi Jenq, Cheng-Chieh Hung, Chih-Wei Yang, and Yung-Chang Chen. Elevation of Interleukin-18 Correlates with Cardiovascular, Cerebrovascular, and Peripheral Vascular Events: A Cohort Study of Hemodialysis Patients. Medicine. 2015 Oct;94(42):e1836.
(22) Cheng-Hung Lee , Kuo-Sheng Liu , Shang-Hung Chang , Wei-Jan Chen , Kuo-Chun Hung , Shih-Jung Liu* , Jong-Hwei S. Pang , Jyuhn-Huarng Juang , Chou Chung-Chuan , Po-Cheng Chang , Yi-Ting Chen , Fu-Shing Wang. Promoting Diabetic Wound Therapy Using Biodegradable rhPDGF-loaded Nanofibrous Membranes: CONSORT-Compliant Article. Medicine. 2015 Nov;94(47):e1873.
(23) Chia-Hung Yang, Chih-Hsiang Chang, Tien-Hsing Chen, Pei-Chun Fan, Su-Wei Chang, Chun-Chi Chen, Pao-Hsien Chu, Yi-Ting Chen, Huang-Yu Yang, Chih-Wei Yang, Yung-Chang Chen. Combination of Urinary Biomarkers Improve Early Detection of Acute Kidney Injury in Patients with Heart Failure. Circulation Journal, 2016, 25;80(4):1017-23.
(24) Cheng-Hung Lee, Yin-Kai Chao, Shang-Hung Chang, Wei-Jan Chen, Kuo-Chun Hung, Shih-Jung Liu,* Jyuhn-Huarng Juang, Yi-Ting Chen and Fu-Shing Wang. Nanofibrous rhPDGF-eluting PLGA–collagen hybrid scaffolds enhance healing of diabetic wounds. RSC Adv., 2016, 6, 6276–6284.
(25) Jau-Song Yu, Yi-Ting Chen, Wei-Fang Chiang, Yung-Chin Hsiao, Lichieh Julie Chu, Lai-Chu See, Chi-Sheng Wu, Hui-Tzu Tu, Hsiao-Wei Chen, Chia-Chun Chen, Wei-Chao Liao, Ya-Ting Chang, Chih-Ching Wu, Che-Yi Lin, Shyun-Yeu Liu, Shu-Ti Chiou, Shu-Li Cha, Kai-Ping Chang, Chih-Yen Chien, Chee-Jen Chang, John D. Young, Chia C. Pao, Yu-Sun Chang*, Leland H. Hartwell*, Saliva protein biomarkers to detect oral squamous cell carcinoma in a high-risk population in Taiwan, PNAS, 2016, 113, 11549–11554. (Co-first author).
(26) Yi-Ting Chen*, Hsiao-Wei Chen, Chun-Feng Wu, Lichieh Julie Chu, Wei-Fang Chiang, Chih-Ching Wu, Jau-Song Yu, Cheng-Han Tsai, Kung-Hao Liang, Yu-Sun Chang, Maureen Wu, Wei-Ting Ou Yang, Development of a multiplexed LC-MRM/MS method for evaluation of salivary proteins as oral cancer biomarkers. Mol. Cell Proteomics. 16, 799-811. 2017.
(27) Chi-hung Shao, Chien-Lun Chen, Chao-Jung Chen, Shu-Hsuan Fu, Yi-Ting Chen, Yu-Sun Chang, Jau-Song Yu, Chiun-Gung Juo*, Kun-Pin Wu*, Metabolite marker discovery for the detection of bladder cancer by comparative metabolomics. Oncotarget, 2017 Jun 13;8(24):38802-38810. 2017.
(28) Yung-Chin Hsiao, Lang-Ming Chi, Kun-Yi Chien, Wei-Fan Chiang, Szu-Fan Chen, Yao-Ning Chuang, Shih-Yu Lin, Chia-Chun Wu, Ya-Ting Chang, Lichieh Julie Chu, Yi-Ting Chen, Shu-Li Chia, Chih-Yen Chien, Kai-Ping Chang,Yu-Sun Chang, and Jau-Song Yu, Development of a multiplexed assay for oral cancer candidate biomarkers using peptide immunoaffinity enrichment and targeted mass spectrometry. Mol. Cell Proteomics. 2017 Oct;16(10):1829-1849.
(29) Cheng-Han Tsai, Yi-Ting Chen*, Clinical proteomics of genitourinary cancer for the development of biomarkers. Clinics in Oncology, 2017, 2, 1326-1327.
(30) Ting-Wen Chen, Chi-Ching Lee, Hsuan Liu, Chi-Sheng Wu, Curtis R. Pickering, Po-Jung Huang, Jing Wang, Ian Yi-Feng Chang, Yuan-Ming Yeh, Chih-De Chen, Hsin-Pai Li, Ji-Dung Luo, Bertrand Chin-Ming Tan, Timothy En Haw Chan, Chuen Hsueh, Lichieh Julie Chu, Yi-Ting Chen, Bing Zhang, Chia-Yu Yang, Chih-Ching Wu, Chia-Wei Hsu, Lai-Chu See, Petrus Tang, Jau-Song Yu, Wei-Chao Liao, Wei-Fan Chiang, Henry Rodriguez, Jeffrey N. Myers, Kai-Ping Chang* & Yu-Sun Chang*. APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism. NATURE COMMUNICATIONS. 2017, 8: 465.
(31) Yung-Chin Hsiao, Lichieh Julie Chu, Yi-Ting Chen, Lang-Ming Chi, Kun-Yi Chien, Wei-Fan Chiang, Ya-Ting Chang, Szu-Fan Chen, Wei-Shun Wang, Yao-Ning Chuang, Shih-Yu Lin, Chih-Yen Chien, Kai-Ping Chang, Yu-Sun Chang, and Jau-Song Yu. Variability assessment of 90 salivary proteins in intra-day and inter-day samples from healthy donors by multiple reaction monitoring-mass spectrometry. Proteomics Clinical Applications, 2018 Mar;12(2). doi: 10.1002/prca.201700039. Epub 2018 Feb 7.
(32) Cheng-Han Tsai1, Yi-Ting Chen*, Ying-Hsu Chang, Chuen Hsueh, Chung-Yi Liu, Yu-Sun Chang, Chien-Lun Chen*, Jau-Song Yu*. Systematic Verification of Bladder Cancer-Associated Tissue Protein Biomarker Candidates in Clinical Urine Specimens. Oncotarget, 2018, 9:30731-30747. (Co-first author and co-corresponding author).
(33) Cheng-Chia Lee, Chih-Hsiang Chang, Shao-Wei Chen*, Pei-Chun Fan, SuWei Chang, Yi-Ting Chen, Yu-Yun Nan, Pyng-Jing Lin, Feng-Chun Tsai. Preoperative Risk Assessment Improves Biomarker Detection for Predicting Acute Kidney Injury After Cardiac Surgery, PLOS ONE, 2018, 13 (9), e0203447.
(34) Wei-Cheng Lin, Archan Chakraborty, Shih-Chia Huang, Pei-Yu Wang, Ya-Ju Hsieh, Kun-Yi Chien, Yen-Hsien Lee, Chia-Chun Chang, Hsiang-Yu Tang, Yu-Tsun Lin, Chang-Shung Tung, Ji-Dung Luo, Ting-Wen Chen, Tzu-Yang Lin, Mei-Ling Cheng, Yi-Ting Chen, Chau-Ting Yeh, Ji-Long Liu, Li-Ying Sung, Ming-Shi Shiao, Jau-Song Yu, Yu-Sun Chang, and Li-Mei Pai*. Histidine-dependent protein methylation is required for compartmentalization of CTP Synthase, Cell Reports, 2018, 24, 2733–2745.
(35) Cheng-Chia Lee, Ya-Ju Hsieh, Shao-Wei Chen, Shu-Hsuan Fu, Chia-Wei Hsu, Chih-Ching Wu, Wei Han, Yunong Li, Huan Tao, Yu-Sun Chang, Jau-Song Yu, Liang Li, Chih-Hsiang Chang, Yi-Ting Chen*, Bretschneider solution-induced alterations in the urine metabolome in cardiac surgery patient. Scientific Reports, 2018, 8, Article number: 17774.
(36) Yi-Ting Chen*, Cheng-Han Tsai, Chien-Lun Chen, Jau-Song Yu, Ying-Hsu Chang*. Development of Biomarkers of Genitourinary Cancer using Mass Spectrometry-Based Clinical Proteomics, Journal of Food and Drug Analysis, 2019, 27, 2: 387-403.
(37) Yi-Ting Chen*, Hsin-Chien Huang, Ya-Ju Hsieh, Shu-Hsuan Fu, Liang Li, Chien-Lun Chen, Lichieh Julie Chu, Jau-Song Yu. Targeting amine- and phenol-containing metabolites in urine by dansylation isotope labeling and liquid chromatography mass spectrometry for evaluation of bladder cancer biomarkers. Journal of Food and Drug Analysis, 2019, 27(2), 460-474.
(38) Chia-Wei Hsu, Yi-Ting Chen, Ya-Ju Hsieh, Kai-Ping Chang, Pei-Chun Hsueh, Ting-Wen Chen, Jau-Song Yu, Yu-Sun Chang, Liang Li*, Chih-Ching Wu*. Integrated analyses utilizing metabolomics and transcriptomics reveal perturbation of the polyamine pathway in oral cavity squamous cell carcinoma. Analytica Chimica Acta. 2019, 1050, 113-122. (Co-first author)
(39) Jia-Jin Chen, Pei-Chun Fan, George Kou, Su-Wei Chang, Yi-Ting Chen, Cheng-Chia Lee, Chih-Hsiang Chang*, Meta-analysis: urinary calprotectin for discrimination of intrinsic and prerenal acute kidney injury, J. Clin. Med., 2019, 8(1), E74.
(40) Pei-Chun Fan, Jason Chih-Hsiang Changa, Chia-Ni Lin,Cheng-Chia Leea, Yi-Ting Chen, Pao-Hsien Chu, George Koua, Yueh-An Lu, Chih-Wei Yang, Yung-Chang Chen*. Serum Indoxyl Sulfate Predicts Adverse Cardiovascular Events in Patients with Chronic Kidney Disease. Journal of the Formosan Medical Association, 2019, 118, 1099-1106.
(41) Hao-Wei Chu, Kai-Ping Chang, Chia-Wei Hsu, Ian Yi-Feng Chang, Hao-Ping Liu, Yi-Ting Chen, and Chih-Ching Wu, Identification of salivary biomarkers for oral cancer detection with untargeted and targeted quantitative proteomics approaches. Molecular & Cellular Proteomics. 2019, 18(9), 1796-1806.
(42) Yi-Ting Chen*, Wei-Ting Ou Yang, Horng-Heng Juang, Chien-Lun Chen*, Hsiao-Wei Chen, Ke-Hung Tsui, Ying-Hsu Chang, Cheng-Han Tsai, Chuen Hsueh, Wei-Chao Liao, Proteomic characterization of arsenic and cadmium exposure in bladder cells", Rapid Commun Mass Spectrom. 2020;34(S1):e8578.
(43) Cheng-Chia Lee, Chih-Hsiang Chang, Ya-Lien Cheng, George Kuo, Shao-Wei Chen, Yi-Jung Li, Yi-Ting Chen, Ya-Chung Tian*, Diagnostic performance of Cyclophilin A in cardiac surgery-associated acute kidney injury. J. Clin. Med. 2020, 9, 108; doi:10.3390/jcm9010108.
(44) Pei-Chun Hsueh; Kuo-An Wu; Chia-Yu Yang; Chia-Wei Hsu; Chih-Liang Wang; Chu-Mi Hung; Yi-Ting Chen; Jau-Song Yu; Chih-Ching Wu*. Metabolomic profiling of parapneumonic effusion reveals a regulatory role of dipeptides in interleukin-8 production in neutrophil-like cells. Analytica Chimica Acta. 2020, 1128, 238-250.
(45) Jo-Chuan Liu, Yi-Ting Chen, Ya-Ju Hsieh, Chia-Chun Wu, Ming-Chyi Huang, Yu-Chao Hsu, Chun-Te Wu, Chih-Ken Chen, Srinivas Dash & Jau-Song Yu*. Association of urinary ketamine and APOA1 levels with bladder dysfunction in ketamine abusers revealed via proteomics and targeted metabolite analyses. Sci. Rep. 11, 9583 (2021). .
(46) Jia?You Lin, Bao?Rong Juo, Yu?Hsuan Yeh, Shu?Hsuan Fu, Yi?Ting Chen, Chien?Lun Chen* and Kun?Pin Wu*. Putative markers for the detection of early-stage bladder cancer selected by urine metabolomics, BMC Bioinformatics. 2021, 22, 305. .
(47) Ming-Yu Fang, Kuan-Hsun Huang, Wei-Ju Tu, Yi-Ting Chen, Pei-Yun Pan, Wan-Chi Hsiao, Yi-Yu Ke, Lun K. Tsou, Mingzi M. Zhang*. Chemoproteomic profiling reveals cellular targets of nitro-fatty acids. Redox Biology. 46, 102126 (2021). .
(48) Ya-Ju Hsieh, Kun-Yi Chien, Chun-Ming Chang, Cheng-Yu Hung, Liang Li, Wei-Fan Chiang5, Cheng-Chia Lee, Chih-Hsiang Chang, Ying-Hsu Chang, Jau-Song Yu*, Yi-Ting Chen*. Development of a Method for Dansylation of Metabolites Using Organic Solvent-Compatible Buffer Systems for Amine/Phenol Submetabolome Analysis. Analytica Chimica Acta. 2022, 1189, 339218.
(49) Eric Yi-Hsiu Huang, Yu-Kuang Chen, Chen-Pu Ou, Yi-Ting Chen, Sung-Fang Chen, William J. Huang, Kung-Hao Liang * Oncogenic roles of Polycomb Repressive Complex 2 in bladder cancer and upper tract urothelial carcinoma. Biomedicines. 2022 Nov 14;10(11):2925. doi: 10.3390/biomedicines10112925.
(50) Yi-Ting Chen, Wan-Rou Liao, Hsueh-Ting Wang, Hsiao-Wei Chen, Sung-Fang Chen*. Targeted Protein Quantitation in Human Body Fluids by Mass Spectrometry. Mass Spectrom Rev. 2023.; 42(6):2379-2403. doi: 10.1002/mas.21788.
(51) Chien-Lun Chen, Yi-Ting Chen, Wen-Yu Liao, Yu-Sun Chang, Jau-Song Yu, and Bao-Rong Juo*, Urinary Metabolomic Analysis of Prostate Cancer by UPLC-FTMS and UPLC-Ion Trap MSn. Diagnostics. 2023, 13, 2270.
(52) Yi-Ting Chen*, Wei-Ju Tu, Zong-Han Ye, Chih-Ching Wu, Shir-Hwa Ueng, Kai-Jie Yu, Chien-Lun Chen, Pei-Hua Peng, Jau-Song Yu, Ying-Hsu Chang*, Integration of the cancer cell secretome and transcriptome reveals potential noninvasive diagnostic markers for bladder cancer. Proteomics Clin. Appl. 2024 Jan 9:e2300033. .
(53) Chih-Hsiang Chang, Cheng-Chia Lee, Yung-Chang Chen, Pei-Chun Fan, Pao-Hsien Chu, Lichieh Julie Chu, Jau-Song Yu, Hsiao-Wei Chen, Chih-Wei Yang, Yi-Ting Chen*. Identification of endothelial cell protein c receptor by urinary proteomics as a novel prognostic marker in non-recovery kidney injury, International Journal of Molecular Sciences, 2024, 25(5), 2783; .