蘇文慧 / Wen-Hui Su
职称: 副教授
现职: 生物醫學系 副教授 / Associate Professor
电话: +886-3-211-8800 ext.3564(office),3528(Lab)
学歷: 國防醫學院 博士
专长领域: 生物资讯、癌症基因体学、分子流行病学
研究方向及研究室特色
癌症做為一种遗传的疾病,许多关於癌症的变化,常是先在染色体中发生,进而影响基因的表现,而导致癌症发生,或形成癌症特殊的标誌。我们在染色体上找到与癌症相关的变化,可以分為两大类。一类為在生殖细胞(germline cells)就有的变异,例如单一核酸变异(SNP)或是复製数变异(copy number variation),让带有这些变异或基因型的人较其他人更容易得病,我们可以利用全基因体关联性分析(genome-wide association study) 的方法,来研究有哪些变异会造成对疾病的感受性的差异。进而去找到造成这种感受性差异的癌症基因。另一类,则是在体细胞(somatic cells)中成形的癌组织内,常会见到的是染色体畸变(chromosome aberration)和基因表现改变的现象,我们也可以利用生物资讯和比较基因体学的方法,将目前已有的这些资讯整合起来,试着找出与癌症的标誌基因。在我们实验室里,就是试着以系统生物学和遗传统计的方法,将这些讯息进行整合,试着找出与鼻咽癌(nasopharyngeal carcinoma)和肝癌(hepatocellular carcinoma)相关的感受性标誌及标誌基因。论文与着作
Publications:
- Wang Jin, Zhao Lei, Sun Xu, Zhou Fachen, Zhang Yixiang, Zhao Shilei, Guo Tao, Sun Zhe, Li Fengzhou, Wen-Hui Su, and Gu Chundong (2021) Genetic Mutation Analysis in Small Cell Lung Cancer by a Novel NGS-Based Targeted Resequencing Gene Panel and Relation with Clinical Features. BioMed Research International 2021 Article ID 3609028.
- Muyun Peng, Qi Huang, Wei Yin, Sichuang Tan, Chen Chen, Wenliang Liu, Jingqun Tang, Xiang Wang, Bingyu Zhang, Min Zou, Jina Li, Wenhui Su, Lientu Wang, Lihan Chin and Fenglei Yu (2020) Circulating Tumor DNA as a Prognostic Biomarker in Localized Non-small Cell Lung Cancer. Frontiers in Oncology 10: 1875
- Xiao-Yu Zuo, Qi-Sheng Feng, Jian Sun, Pan-Pan Wei, Yoon-Ming Chin, Yun-Miao Guo, Yun-Fei Xia, Bo Li, Xiao-Jun Xia, Wei-Hua Jia, Jian-Jun Liu, Alan Soo-Beng Khoo, Taisei Mushiroda, Ching-Ching Ng*?, Wen-Hui Su?, Yi-Xin Zeng?, and Jin-Xin Bei? (2019) X-chromosome association study reveals genetic susceptibility loci of nasopharyngeal carcinoma. Biology of Sex Differences 10:13 (?equal contributed corresponding author)
- Wen-Hui Su*, Yuh-Shan Jou, Jia-Hao Zhang, Chun-Ming Ho, Dar-In Tai (2018) Mutations in NOTCH1 and nucleotide excision repair genes are correlated with prognosis of hepatitis B virus-associated hepatocellular carcinoma. Journal of Cancer 9(15): 2678-2686 (*Corresponding author)
- The Telomeres Mendelian Randomization Collaboration (2017) Association between telomere length and risk of cancer and non-neoplastic diseases a mendelian randomization study. JAMA Oncology 3(5):636-651
- Jin-Xin Bei?, Wen-Hui Su?, Ching-Ching Ng?, Kai Yu, Yoon-Ming Chin, Pei-Jen Lou, Wan-Lun Hsu, James D. McKay, Chien-Jen Chen, Yu-Sun Chang, Jian-Jun Liu, Yi-Xin Zeng, and Allan Hildesheim for the International Nasopharyngeal Carcinoma Genetics Working Group (2016) A GWAS meta-analysis and replication study identifies a novel locus within CLPTM1L/TERT associated with nasopharyngeal carcinoma in individuals of Chinese ancestry. Cancer Epidemiology Biomarkers & Prevention 25(1):188-92 (?equal contributed first author)
- Wen-Hui Su*, Chi-Cking Chiu, Yin Yao Shugart (2015) Heterogeneity revealed through meta-analysis might link geographical differences with nasopharyngeal carcinoma incidence in Han Chinese population. BMC Cancer 15:598. (*Corresponding author)
- Su-Wei Chang, Cathy Shen-Jang Fann, Wen-Hui Su, Yu Chen Wang, Chia Chan Weng, Chia-Jung Yu, Chia-Lin Hsu, Ai-Ru Hsieh, Rong-Nan Chien, Chia-Ming Chu, Dar-In Tai (2014) A Genome-Wide Association Study on Chronic HBV Infection and Its Clinical Progression in Male Han-Taiwanese. PLoS One 9(6):e99724.
- Wen-Hui Su*, Yin Yao Shugart, Kai-Ping Chang, Ngan-Ming Tsang, Ka-Po Tse, and Yu-Sun Chang (2013) How Genome-Wide SNP-SNP Interactions Relate to Nasopharyngeal Carcinoma Susceptibility. PLoS One 8(12):e83034. (*Corresponding author)
- Wen-Hui Su*, Allan Hildesheim, and Yu-Sun Chang (2013) Human Leukocyte Antigens and Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma: Old Associations Offer New Clues into the Role of Immunity in Infection-Associated Cancers. Frontiers in Oncology 3(299):1-9. (Invited Review) (*Corresponding author)
- Wan-Lun Hsu, Ka-Po Tse, Sharon Liang, Yin-Chu Chien, Wen-Hui Su, Kelly Yu, Yu-Juen Cheng, Ngan-Ming Tsang, Mow-Ming Hsu, Kai-Ping Chang, I-How Chen, Tzu-I Chen, Czau-Siung Yang, Alisa Goldstein, Chien-Jen Chen, Allan Hildesheim, and Yu-Sun Chang (2012) Evaluation of Human Leukocyte Antigen-A (HLA-A), Other non-HLA Markers on Chromosome 6p21 and Risk of Nasopharyngeal Carcinoma. PLoS One 7(8): e42767.
- Lin KT, Wang YW, Chen CT, Ho CM, Su WH, and Jou YS. (2012) HDAC inhibitors augmented cell migration and metastasis through induction of PKCs leading to identification of low toxicity modalities for combination cancer therapy. Clinical Cancer Research 18(17): 4691-4701.
- C-Y Chang, S-C Lin, W-H Su, C-M Ho, and Y-S Jou. (2012) Somatic LMCD1 mutations promoted cell migration and tumor metastasis in hepatocellular carcinoma. Oncogene 31(21):2640-52.
- Sen Kao, Cheng-Kai Shiau, De-Leung Gu, Chun-Ming Ho, Wen-Hui Su, Chian-Feng Chen, Chi-Hung Lin, Yuh-Shan Jou. (2012) IGDB.NSCLC: Integrated Genomic Database of Non-Small Cell Lung Cancer. Nucleic Acids Research 40(Database issue): D972-7.
- Ka-Po Tse?, Wen-Hui Su?, Min-lee Yang, Hsiao-Yun Cheng, Ngan-Ming Tsang, Kai-Ping Chang, Sheng-Po Hao, Yin Yao Shugart, and Yu-Sun Chang. (2011) A gender-specific association of CNV at 6p21.3 with NPC susceptibility. Human Molecular Genetics 20(14):2889-2896. (SCI: Impact factor: 5.340, 23/166 GENETICS & HEREDITY) (?equal contributed first author)
- Chih-Ching Wu, Chia-Wei Hsu, Chi-De Chen, Chia-Jung Yu, Kai-Ping Chang, Dar-In Tai, Hao-Ping Liu, Wen-Hui Su, Yu-Sun Chang, and Jau-Song Yu (2010) Candidate Serological Biomarkers for Cancer Identified from the Secretomes of 23 Cancer Cell Lines and the Human Protein Atlas. Molecular and Cellular Proteomics 9(6):1100-17.
- Ka-Po Tse?, Wen-Hui Su?, Kai-Ping Chang, Ngan-Ming Tsang, Chia-Jung Yu, Petrus Tang, Lee-Chu See, Chuen Hsueh, Min-Lee Yang , Sheng-Po Hao, Hong-Yi Li, Ming-Hsi Wang, Li-Ping Liao, Lih-Chyang Chen, Sheue-Rong Lin, Yu-Sun Chang, and Yin Yao Shugart. (2009) Genome-wide association study reveals multiple nasopharyngeal Carcinoma-associated loci within the HLA region at chromosome 6p21.3. American Journal of Human Genetics 85(2):194-203 (?equal contributed first author) (NSC 99-3112-B-182-006)
- Wen-Hui Su, Chuan-Chuan Chao, Shiou-Hwei Yeh, Ding-Shinn Chen, Pei-Jer Chen, and Yuh-Shan Jou. (2007) OncoDB.HCC: An integrated genomic database of hepatocellular carcinoma revealed aberrant cancer target genes and loci. Nucleic Acids Research, 35:D727-D731.
- Ya-Hui Chang?, Wen-Hui Su?, Tso-Ching Lee, Hsiao-Fang Sunny Sun, Chia-Hsaing Chen, Wen-Harn Pan, Shih-Feng Tsai and Yuh-Shan Jou(2005)TPMD: A Database and Resources of Microsatellite Marker Genotyped in Taiwanese Populations. Nucleic Acids Research 33:D174-D177. (SCI: Impact factor: 10.162, 14/286 BIOCHEMISTRY & MOLECULAR BIOLOGY) (?equal contributed first author).