蕭慧怡/Hui-Yi Hsiao
职称： 助理教授
现职： 助理教授
电话： 03-2118800#3717
学歷： 美国纽约大学生物学博士
专长领域： 组织工程、再生医学、干细胞生物学、淋巴水肿研究
工作经歷
2023 Aug~present: 助理教授&苍产蝉辫;长庚大学 生物醫學系
2020 Sep~2023 July: 兼任助理教授&苍产蝉辫;明志科技大学，智慧医疗博士学程
2022 Aug~ 2023 July: 副研究员&苍产蝉辫;長庚醫院 組織工程中心
2017 Aug~ 2022 July: 助理研究员&苍产蝉辫;長庚醫院 組織工程中心
研究方向及研究室特色
实验室的研究有以下两大方向：
1. 组织工程应用於硬组织与软组织的再生
组织工程的技术常被应用於再生医学。组织工程的方式大多将细胞、生物材料和生长因子结合起来，促进组织再生来修復或替换受损组织。组织工程的研究主要致力於设促进血管生成和细胞分化以用来进行新组织的再生。我们的实验室主要是结合成人干细胞和生物材料来设计客製化的3D 组织结构，其后续可应用於不同组织的再生 (Fig. 1). 實驗室研究對於再生的組織的目標涵蓋了硬組織 （硬骨、軟骨）與軟組織 （脂肪、淋巴組織、毛髮）。
2. 探討淋巴水腫的機制與治療的方針
淋巴水肿起因於淋巴回流受阻导致的组织间隙中多餘淋巴液体异常的堆积。淋巴水肿可分为原发性和继发性淋巴水肿。原发性淋巴水肿主要是先天性的淋巴系统异常发育。继发性淋巴水肿则是由感染、癌症或辐射导致淋巴系统受损引起的。在乳腺癌或妇科癌症患者进行肿瘤与淋巴结切除和放疗后，大约有40％的乳腺癌患者和20-49％的妇科癌症患者出现淋巴回流功能异常的併发症，导致淋巴液堆积在组织当中造成淋巴水肿的现象。目前对於淋巴水肿的发展过程以及引起淋巴水肿症状的具体机制了解甚少。此外，如何治疗或预防淋巴水肿的研究对於未来的临床应用也非常重要。在我们的实验室中，我们致力於研究淋巴水肿的机制，并寻找可行的淋巴水肿治疗与预防的方法（Fig.2）。
论文与着作
(Selected Publications)
1. Hsiao HY, J.W. Liu, M. Pappalardo, M.H. Cheng, The Impacts of Lymph on the Adipogenesis of Adipose-Derived Stem Cells, Plast Reconstr Surg (2023).
2. Hsiao HY, W.C. Hsieh, F.C. Chang, J.W. Liu, W.L. Kuo, D.C. Cheong, J.J. Huang, The Effect of Negative Pressure on Wound Healing and Regeneration in Closed Incisions under High Tension: Evidence from Animal Studies and Clinical Experience, 2022 J Clin Med 12(1)
3. Sakarya AH, Huang CW, Yang CY, Hsiao HY, Chang FC, Huang JJ. Vascularized lymph node transplantation successfully reverses lymphedema and maintains immunity in a rat lymphedema model. Bioeng Transl Med. 2022 Feb;7:e10301
4. Hsiao HY, Nien CY, Hong HH, Cheng MH, Yen TH. Application of dental stem cells in three-dimensional tissue regeneration. World J Stem Cells 2021Nov;13:1610-24
5. Huang CW, Chang YC, Hsiao HY, Liu JW, Chang FC, Huang JJ. Creation of a rat lymphedema model using extensive lymph node dissection and circumferential soft tissue resection: Is this a reliable model? Microsurgery 2021Nov;41:762-71.
6. Hsiao HY, Lai CY, Liu JW, Yu YY, Chang FC, Huang JJ. Fate of Fat Grafting In Vivo and In Vitro: Does the Suction-Assisted Lipectomy Device Matter? Aesthet Surg J 2021 Sep ;41:NP1323-NP36.
7. Hsiao HY, Cheng CM, Kao SW, et al. The effect of bone inhibitors on periosteum-guided cartilage regeneration. Sci Rep 2020 May;10:8372.
8. Hsiao HY, Chung CW, Santos JH, Villaflores OB, Lu TT. Fe in biosynthesis, translocation, and signal transduction of NO: toward bioinorganic engineering of dinitrosyl iron complexes into NO-delivery scaffolds for tissue engineering. Dalton Trans 2019 Apr;48:9431-53.
9. Hsiao HY, Yang CY, Liu JW, Brey EM, Cheng MH. Periosteal Osteogenic Capacity Depends on Tissue Source. Tissue Eng Part A 2018 Dec;24:1733-41.
10. Yang CY, Ho OA, Cheng MH, Hsiao HY*. Critical Ischemia Time, Perfusion, and Drainage Function of Vascularized Lymph Nodes. Plast Reconstr Surg 2018 Sep;142:688-97.
11. Ng CY, Yen H, Hsiao HY*, Su SC. Phytochemicals in Skin Cancer Prevention and Treatment: An Updated Review. Int J Mol Sci 2018 March;19(4):941
12. Hsiao HY, Yang SR, Brey EM, Chu IM, Cheng MH. Hydrogel Delivery of Mesenchymal Stem Cell-Expressing Bone Morphogenetic Protein-2 Enhances Bone Defect Repair. Plast Reconstr Surg Glob Open 2016 Aug;4:e838.
13. Hsiao HY, Liu JW, Brey EM, Cheng MH. The Effects of Negative Pressure by External Tissue Expansion Device on Epithelial Cell Proliferation, Neo-Vascularization and Hair Growth in a Porcine Model. PLoS One 2016 Apr;11:e0154328.
14. Hsiao HY, Jukam D, Johnston R, Desplan C. The neuronal transcription factor erect wing regulates specification and maintenance of Drosophila R8 photoreceptor subtypes. Dev Biol 2013 Sep;381:482-90.
15. Hsiao HY, Johnston RJ, Jr., Jukam D, Vasiliauskas D, Desplan C, Rister J. Dissection and immunohistochemistry of larval, pupal and adult Drosophila retinas. J Vis Exp 2012 Nov:4347.
16. Hsiao HY, He Q, Van Waasbergen LG, Grossman AR. Control of photosynthetic and high-light-responsive genes by the histidine kinase DspA: negative and positive regulation and interactions between signal transduction pathways. J Bacteriol 2004 Jun;186:3882-8.