91猫先生

授课教师

顏秀娟

开课单位

生医所博士班

年级-班别

1-甲

科目代号(学分)

BMD466(2)

课程名称

自由基生物医学

开课序号

64112

主要开课序号

修课学生

本校: 1人；外校: 0人

人数限制

0~60

上课时间地点

核心能力

备註

英文授课

教科书

B. Halliwell and J. M. C. Gutteridge. Free radicals in biology and medicine, 5th Ed., 2015 (electronic version: https://doi.org/10.1093/acprof:oso/9780198717478.001.0001 ).

教科书ISBN

0000000000

参考书

Current literatures indicated in handouts.

课程讲义网址

E-learning system

整体教学目标

Free Radical Biology and Medicine or redox biology has been an important subfield invovled in various aspects of biomedical sciences. This course will provide fundamental knowledge for the understanding on the basics of reactive oxygen species (ROS)/reactive nitrogen species (RNS) and the antioxidant systems in biological systems, role of oxidative stress in the pathogenesis of diseases, and the techniques for evaluating oxidative stress or oxidative damage.

教学方法

This is a class lectured in English, but questions and interaction in Chinese are allowed. Lecturers will prepare handouts for students. Open-book midterm will be given to examine how students understand the basic concepts of this field for the lectures in the first half of the class. As the end of the semester, students will be asked to provide a slide presentation video in class and a written report for the same topic as to how this field can be applied to various subfields in biomedicine of their interests.

课程介绍

上课教室在第一医学大楼11楼第二会议室。本课程的第一部分专注於自由基生物学之基本知识:ROS/RNS之化学性质和来源; 脂质、核酸、和蛋白氧化伤害及其产物之分析方法; 体内之抗氧化系统。在第二部分，我们会讨论此领域的各项应用，包含在培养细胞中和活体内评估氧化压力之方法; redoxomics之应用; 氧化压力在病毒感染、G6PD缺乏、心血管疾病、中風、和毒藥物毒性中的角色。最後，學生要做期末口頭和書面報告，討論如何將自由基生物医学應用在有興趣的主題。

弹性学习

Videos for free radical biology and medicine (2 hours). Links to the videos will be announced on the E-learning system.

成绩考核

Midterm exam (open-book exam): 50%; Final slide presentation: 20%; Final written report: 20%; Discussion and quuestions for slide presentation: 10%; Deductions of the final grade (2 points) for each unauthorized absence in the class

师生互动时间

Monday 2-3 pm Contact information of Prof. HC Yen (顏秀娟): yen@mail.cgu.edu.tw; ext. 5207

项次

教学主题

1

1. 授课内容: Introduction to free radicals, reactive oxygen species (ROS)/reactive nitrogen species (RNS), and their roles in basic and clinical medicine 2. 授课老师: 顏秀娟 (HC Yen)

2

1. 授课内容: Chemistry of ROS/RNS and sources of ROS/RNS in biological systems 2. 授课老师: 顏秀娟 (HC Yen)

3

1. Holiday 2. 授课老师: 顏秀娟 (HC Yen)

4

1. 授课内容: Lipid peroxidation 2. 授课老师: 顏秀娟 (HC Yen)

5

1. 授课内容: Oxidative damage to nucleic acids 2. 授课老师: 郑美玲 (ML Cheng)

6

1. 授课内容: Oxidative damage to proteins 2. 授课老师: 顏秀娟 (HC Yen)

7

1. 授课内容: Antioxidant enzymes 2. 授课老师: 顏秀娟 (HC Yen)

8

1. 授课内容: Low-molecular-weight antioxidants 2. 授课老师: 顏秀娟 (HC Yen)

9

1. 授课内容: Open-book midterm exam 2. 授课老师: 顏秀娟 (HC Yen)

10

1. 授课内容: Redoxomics as a new approach in redox biology 2. 授课老师:何鸿耀 (HY Ho)

11

1. 授课内容: Oxidative stress and viral infection 2. 授课老师: 何鸿耀 (HY Ho)

12

1. 授课内容: Speicial topics on glucose-6-phosphate dehydrogenase (G6PD) 2. 授课老师: 郑美玲 (ML Cheng)

13

1. 授课内容: Considerations and techniques for accessing oxidative stress in cultured cells, animals, and in clinical studies 2. 授课老师: 顏秀娟 (HC Yen)

14

1. 授课内容: Oxidative stress in stroke and cardiovascular diseases 2. 授课老师: 顏秀娟

15

1. 授课内容: Oxidative stress and toxicity of xenobiotics 2. 授课老师: 顏秀娟 (HC Yen)

16

1. 授课内容: Student presentation for the selected topics 2. 授课老师: 顏秀娟 HC Yen)

本課程沒有先修课程規定