91猫先生

授课教师

李国铭

开课单位

生医所博士班

年级-班别

1-甲

科目代号(学分)

BMD403(2)

课程名称

细胞分子生物学

开课序号

64109

主要开课序号

62563

修课学生

本校: 6人；外校: 0人

人数限制

2~60

上课时间地点

核心能力

备註

英文授课，与新兴病毒学程合开

教科书

Lecture slides

教科书ISBN

0000000000

参考书

Molecular cell biology by Harvey Lodish et al., 7th Edition (2013) (ISBN:9781464183393); Molecular Biology by Robert Weaver, 5th Edition (2012) (ISBN:9780071316866); Fields virology by Peter M. Howley et al., 7th Edition (2021) (ISBN: 9781975112578)

课程讲义网址

E-learning: https://moocs.cgu.edu.tw/mooc/index.php Microsoft Teams

整体教学目标

The course is aimed to provide a comprehensive introduction about how the various components in a cell cooperate with each other to maintain cell growth and replication by combining textbook with the latest finding in various topics of cell & molecular biology. Based on this, we will further discuss how the virus can successfully replicate by harnessing different host machineries. 本課程旨在藉由搭配教科书知識結合細胞和分子生物學各領域的最新發現，全面介紹細胞中的各種成分如何相互作用以維持細胞生長和複製。並以此為基礎進一步討論病毒如何利用宿主各式各樣的機制進行複製。

教学方法

Lecture and discussion

课程介绍

针对细胞（尤其是真核细胞）中各个基础组成如何运作以满足细胞生长復制的需求进行一般性介绍。除了经典分子生物学的中心法则，我们还将关注基因表现相关的各个领域的最新发现，包括转录、翻译、细胞核质的运送、蛋白质运输和细胞内不同胞器间的交互作用。此外，我们还将讨论 如何藉由CRISPR/Cas、调控 RNA、表观遗传控制和 RNA 修饰等操作基因的表现。最后，我们将解释病毒如何与宿主合作或抢夺宿主资源以完成病毒复製。通过这些内容，学生不仅可以了解细胞是如何运作，还可以了解病毒如何利用宿主细胞资源来促进复製。了解这些重要的分子机制，可以為未来的研究或药物研发提供方向。

弹性学习

Two courses (4 hr): I. 2024/12/24, 1. Flexible learning, on-line and Flipped Classroom, 2. Topic: Prokaryotic and Eukaryotic CRISPR and their Application, 3. Group discussion. II. 2024/12/31, 1. Flexible learning, on-line and Flipped Classroom, 2. Topic: Antiviral Restriction Factors, 3. Group discussion.

成绩考核

Group discussion: 30% Flipped Classroom: 50% Attendance/Participation: 20%

师生互动时间

星期二 12:00 pm-13:00 分机 #3727 李国铭老師联络方式: Kuo-Ming Lee, g39002007@mail.cgu.edu.tw, x-3727 龔俞安老師联络方式: Yu-An Kung, yakung@mail.cgu.edu.tw, x-3039

项次

教学主题

1

1. Physical course 2. Topic: Introduction: I. Overview of the Molecular & Cell Biology, II. Centra dogma of the Molecular Biology 3. Lecturer: Kuo-Ming Lee

2

1. Physical course 2. Topic: Compartmentalization of the Eukaryotic Cell: Nucleus, Nuclear Body, Cytoskeleton, and Extracellular Matrix 3. Lecturer: Kuo-Ming Lee

3

1. Moon Festival 2. Lecturer: Kuo-Ming Lee

4

1. Physical course 2. Topic: Genome Replication, Gene Editing (CRISPR/Cas) and Epigenetic Control 3. Lecturer: Kuo-Ming Lee

5

1. Physical course 2. Topic: Three Major Transcription Machineries of the Cell 3. Lecturer: Kuo-Ming Lee

6

1. Physical course 2. Topic: Transcription Coupled Pre-mRNA Processing (I): Capping and Splicing 3. Lecturer: Kuo-Ming Lee

7

1. Physical course 2. Topic: Transcription Coupled Pre-mRNA Processing (II): Polyadenylation and mRNA Export 3. Lecturer: Kuo-Ming Lee

8

1. Physical course 2. Topic: Translation, Regulatory RNA and RNA Surveillance 3. Lecturer: Kuo-Ming Lee

9

1. Physical course 2. Topic: Virus-Host interaction (I): Cap-independent Translation 3. Lecturer: Yu-An Kung

10

1. Physical course 2. Topic: RNA Modifications and RNA Vaccine 3. Lecturer: Kuo-Ming Lee

11

1. Physical course 2. Topic: I. Protein Maturation and Quality Control, II. Intracellular Protein Traffic: Endocytosis, Exocytosis and Membrane-Bound Extracellular Vesicles 3. Lecturer: Kuo-Ming Lee

12

1. Physical course 2. Topic: Signaling Transduction and Cell Cycle 3. Lecturer: Kuo-Ming Lee

13

1. Physical course 2. Topic: Virus-Host Interaction (II): Pattern Recognition Receptors and Innate Immunity 3. Lecturer: Kuo-Ming Lee

14

1. Physical course 2. Topic: Programmed Cell Death and Necrosis 3. Lecturer: Yu-An Kung

15

1. Physical course 2. Topic: Virus-Host interaction (III): Replication organelles and egress 3. Lecturer: Yu-An Kung

16

1. Physical course 2. Topic: Final Presentaton and Group Discussion 3. Lecturer: Kuo-Ming Lee

本課程沒有先修课程規定