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生物医学研究所

生物医学研究所
:::
徐錦源

徐錦源 / Chin-Yuan Hsu

职称： 教授

现职： 长庚大学

信箱： hsu@mail.cgu.edu.tw

电话： 3416

学歷： 清华大学博士

专长领域： 生理研究;长寿机转

个人网页：

研究方向及研究室特色：


1. The mechanisms of aging and lifespan extension in honeybees.

2. The mechanism of lifespan extension at ambient temperature reduction.

3. Anti-aging drugs screen. 

   &苍产蝉辫;&苍产蝉辫;我们实验室使用蜜蜂研究老化及长寿的分子机转。因為蜜蜂族群数量大，工蜂寿命短(约1-2个月)，蜂王寿命长(约3-5年)，基因体已解码，基因组成类似脊椎动物。我们使用工蜂研究老化的分子机转，蜂王研究长寿的分子机转。我们以老化指标，粒线体能量代谢，能量调节分子，细胞能量代谢，细胞降解作用，细胞免疫作用，细胞讯息传递，分子结构解析及基因调节等主题来探讨工蜂老化的分子机转。同样地，我们也以这些主题来探讨蜂王长寿的分子机转。透过比较工蜂老化及蜂王长寿的分子机转及基因体的比对，企图找出延长人类寿命的分子机转。

&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;生物处於低温环境能延长寿命，相反地，生物处於高温环境会缩短寿命。我们使用工蜂研究低温环境延长寿命的分子机转。我们也以老化指标，粒线体能量代谢，能量调节分子，细胞能量代谢，细胞降解作用，细胞免疫作用，细胞讯息传递，分子结构解析及基因调节等主题来探讨工蜂处於低温环境延长寿命及处於高温环境缩短寿命的分子机转。透过比较工蜂老化，高温环境缩短寿命，蜂王长寿及低温环境延长寿命的分子机转及基因体的比对，企图找出延长人类寿命的分子机转。

&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;透过比较工蜂老化，高温环境缩短寿命，蜂王长寿及低温环境延长寿命的分子机转及基因体的比对，建立长寿的分子机转。由分子结构模拟中建构及中草药中筛选长寿分子机转的活化剂及老化分子机转的抑制剂，建立抗老化药物，以延长人类寿命。

诚挚地欢迎对本实验室研究主题感兴趣的同学加入本实验室的行列。

Publications:

  1. Lu CY, Weng YT, Tan B, Hsu CY* (2021) The trophocytes and oenocytes of worker and queen honey bees (Apis mellifera) exhibit distinct age-associated transcriptome profiles. GeroScience.
  2. Hsu CY*, Weng YT (2021) Long-term inhibition of ferritin2 synthesis in trophocytes and oenocytes by ferritin2 double-stranded RNA ingestion to investigate the mechanisms of magnetoreception in honey bees (Apis mellifera). PLoS ONE 16(8):e0256341.
  3. Hsu CY*, Lo HF, Mutti N.S et al. (2019) Ferritin RNA interference inhibits the formation of iron granules in the trophocytes of worker honey bees (Apis mellifera). Sci Rep 9, 10098.
  4. Lu CY, Qiu JT, Hsu CY* (2018) Cellular energy metabolism is maintained during aging in long-living queen bees. Arch. Insect Biochem. Physiol.Doi:10.1002/arch.21468.
  5. Lu CY, Chuang YL, Hsu CY* (2017) Aging results in a decline in cellular energy metabolism in the trophocytes and oenocytes of worker honeybees (Apis mellifera). Apidologie 48:761-775.
  6. Hsu CY*, Qiu JT, Chan YP, (2016) Cellular degradation activity is maintained during aging in long-living queen bees. Biogerontology 17:829-840.
  7. Lu CY, Hsu CY* (2015) Ambient temperature reduction extends lifespan via activating cellular degradation activity in an annual fish (Nothobranchius rachovii). Age doi:10.1007/s11357-015-9775-z.
  8. Hsu CY*, Lu CY (2015) Mitochondrial energy utilization maintains young status in the trophocytes and fat cells of old queen honeybees. Apidologie doi:10.1007/s13592-015-0348-z.
  9. Hsu CY*, Hu TH (2014) Energy-regulated molecules maintain young status in the trophocytes and fat cells of old queen honeybees. Biogerontology 15:389-400.
  10. Hsu CY*, Chuang YL (2014) Changes in energy-regulated molecules in the trophocytes and fat cells of young and old worker honeybees. J. Gerontol. Ser. A Biol. Sci. Med. Sci. 69:955-964.
  11. Hsu CY*, Hsieh YS (2014) Oxidative stress decreases in the trophocytes and fat cells of worker honeybees during aging. Biogerontology 15:129-137.
  12. Hsu CY*, Chuang YL, Chan YP (2014) Changes in cellular degradation activity in young and old worker honeybees (Apis mellifera) Exp. Gerontol. 50:128-136.
  13. Hsieh YS, Hsu CY* (2013) Oxidative stress and anti-oxidant enzyme activities in the trophocytes and fat cells of queen honeybees (Apis mellifera). Rejuv. Res. 16:295-303.
  14. Chuang YL, Hsu CY* (2013) Changes in mitochondrial energy utilization in young and old worker honeybees. Age 35:1867-1879.
  15. Hsu CY*, Chan YP (2013) The use of honeybees reared in a thermostatic chamber for aging studies. Age 35:149-158.
  16. Hsieh YS, Hsu CY* (2011) The changes of age-related molecules in the trophocytes and fat cells of queen honeybees (Apis mellifera). Apidologie 42:728-739.
  17. Hsu CY*, Chan Y.P. (2011) Identification and localization of proteins associated with biomineralization in the iron deposition vesicles of honeybees (Apis mellifera). PLoS ONE 6(4):e19088. doi:10.1371/journal.pone.0019088
  18. Hsieh YS, Hsu CY* (2011) Honeybee trophocytes and fat cells as target cells for cellular senescence studies. Exp. Gerontol. 46:233-240.
  19. Hsu CY*, Chiu YC (2009) Ambient temperature influences aging in an annual fish (Nothobranchius rachovii). Aging Cell 8:726-737.
  20. Hsu CY*, Chiu YC, Hsu WL, Chan YP (2008) Age-related markers assayed at different developmental stages of the annual fish Nothobranchius rachovii. J. Gerontol. Ser. A Biol. Sci. Med. Sci. 63A:1267-1276.
  21. Hsu CY*) (2008) Antioxidant activity of extracts from Pyrrosia petiolosa. Fitoterapia 79:64-66.
  22. Hsu CY*, Ko FY, Li CW, Fann K, Lue JT (2007) Magnetoreception system in honeybees (Apis mellifera). PLoS ONE 2(4): e395. doi:10.1371/journal.pone.0000395.
  23. Hsu CY* (2004) The processes of iron deposition in the common hornet (Vespa affinis). Biol. Cell 96:529-537.
  24. Liou ML, Hsu CY* (1998) Japanese encephalitis virus transports across the cerebral blood vessels by endocytosis in mouse brain. Cell & Tissue Res. 293:389-394.
  25. Hsu CY, Li CW (1994) Magnetoreception in honeybees (Apis mellifera). Science 265:95-97.

   26. Hsu CY, Li CW (1993) The ultrastructure and formation of iron granules in the honey bee (Apis mellifera). J.           Exp. Biol. 180:1-13.