91猫先生

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生物医学研究所

生物医学研究所
:::
葉儀君

葉儀君 / Yi-Chun Yeh

职称： 助理教授

现职： 长庚大学

信箱： yichunyeh0201@gmail.com

电话： 03-2118800 ext.5253

学歷： 成功大学博士

专长领域： 生理研究;肾臟生理暨病理研究

个人网页：

研究方向及实验室特色：

慢性肾臟疾病是一个全球性的健康问题，也是高龄化社会公共卫生支出的巨大负担与隐忧。在台湾因肾臟衰竭须接受洗肾的人口居高不下，所耗费的医疗资源更佔健保支出之冠。

慢性肾衰的重要特徵之一是肾小管间质纤维化，病理表现是间质中产生过量的细胞外基质，及肾小管上皮细胞的萎缩，进而导致肾臟功能逐渐丧失。对於间质纤维化的详尽机制、细胞外基质物理化学性质的变化、及基质变化如何影响细胞特性的改变、又或是細胞在疾病發展過程中，如何應對不同種細胞間交互的改變等，一直是腎臟纖維化過程中尚未釐清的課題。而其中最根本的問題是：纖維化本身是否可逆? 什麼程度可逆、可清除、又或是可被停止? 而什麼情況下，則會導致不可逆、又或是造成更全面性的影響? 我們藉由細胞及動物實驗模式的建立，希望能更全面了解慢性肾臟疾病发展的过程与机制。希望队学术知识奠定更多基础，更宏观的视野外，也期待对药物的发展，台湾社会经济有长远的建树。

实验室位置：第一医学大楼8楼础区生物医学共同研究室

产学合作：昱星生物科技股份有限公司

发表论文、着作及专利

  1. Cheng YS, Chen HY, Lin YC, Lin YS, Yeh YC, Yeh YH, Cheng YH, Lin YM, Weng HY, Lin TY, Lin SC. The MAEL expression in mitochondria of human spermatozoa and the association with asthenozoospermia. Andrology, 2023 Feb 13.
  2. Dulloo I, Atakpa-Adaju P, Yeh YC, Levet C, Muliyil S, Lu F, Taylor CW, Freeman M. iRhom pseudoproteases regulate ER stress-induced cell death through IP3 receptors and BCL-2. Nat. Commun., 2022 Mar 13(1):1257.
  3. Grieve AG, Yeh YC, Zarcone L, Breuning J, Johnson N, Strisovsky K, Brown MH, Parekh AB, Freeman M. Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation. Mol Cell., 2021 Dec; 81, 4784-4798.
  4. Yeh YC, Lin YP, Kramer H and Parekh AB. Single nucleotide polymorphisms in Orai1 associated with atopic dermatitis inhibit protein turnover, decrease calcium entry and disrupt calcium-dependent gene expression. Hum Mol Genet., 2019 Jul; 21;29(11): 1808-1823, 2019.
  5. Yeh YC, Lin HH, and Tang MJ. Dichotomy of DDR1 functions in epithelial cells. Biochem Biophys Acta Mol Cell Res., 2019 Nov; 1886(11): 118473.

-Review paper.

  1. Yeh YC, and Parekh AB. Calcium Entry Channels in Non-Excitable Cells. Chapter of CRAC channels and Ca2+-dependent gene expression. Editors: Kozak JA and Putney JW. CRC Press/Taylor & Francis, 2018. -Contribute to a Book chapter.
  2. Yeh YC, Ling JY, Chen WC, Lin HH, and Tang MJ. Mechanotransduction of matrix stiffness in the regulation of focal adhesion size and number: reciprocal regulation of caveolin-1 and b1 integrin. Sci Rep., 2017 Nov; 8;7(1): 15008.

-Introduced by Extracellular Matrix News 8.44 November 9, 2017.

-Top 100 read cell biology papers from Scientific Reports in 2017.

  1. Chen HR*, Yeh YC*, Tang MJ, and Wang YK. DDR1 promotes E-cadherin stability via inhibition of Src activation-mediated E-cadherin endocytosis. Sci Rep., 8;6:36336, 2016. (*Co-first author).
  2. Yeh YC, and Parekh AB. Distinct structural domains of caveolin-1 independently regulate CRAC channels and Ca2+ microdomain-dependent gene expression. Mol Cell Biol., 35:1341-1349, 2015.

-Marked on the spotlight section.

  1. Yeh YC, and Tang MJ. Functions of DDR1 in epithelial cell differentiation. Chapter of Discoidin domain receptors in health and disease. Editors: Fridman R and Huang P. Springer Publisher, 2015.

     -Contribute to a Book chapter.

  1. Yeh YC, Tang MJ, and Parekh AB. Caveolin-1 alters the pattern of cytoplasmic Ca2+ oscillation and Ca2+-dependent gene expression by enhancing leukotriene receptor desensitization. J Biol Chem., 289: 17843-17853, 2014.

-Recommended by Faculty 1000 of Cell Biology.

  1. Yeh YC, Lin HH, and Tang MJ. A tale of two collagen receptors, integrin β1 and DDR1, in epithelial cell differentiation. Am J Physiol Cell Physiol., 303: C1207-1217, 2012.

-Review paper.

  1. Yeh YC, Wu CC, Wang YK, and Tang MJ. DDR1 triggers epithelial cell differentiation by promoting cell adhesion through the stabilization of E-cadherin. Mol Biol Cell., 22: 940-953, 2011.
  2. Lin SC, Chien CW, Lee JC, Yeh YC, Hsu KF, Lai YY, Lin SC, and Tsai SJ. Repression of dual specificity phosphatase-2 by hypoxia increases chemoresistance and cancer malignancy. J Clin Invest., 121: 1905-1916, 2011.
  3. Yeh YC, Wei WC, Sung JM, Lin SC, Chang WT, Tang MJ. TGF-β1 induces Smad3-dependent β1 integrin gene expression in epithelial-to-mesenchymal transition during chronic tubulointerstitial fibrosis. Am J Pathol., 177: 1743-1754, 2010.
  4. Wang CZ, Yeh YC, Tang MJ. DDR1/E-cadherin complex regulates the activation of DDR1 and cell spreading. Am J Physiol Cell Physiol
  5. Yeh YC, Wang CZ, Tang MJ. Discoidin domain receptor 1 activation suppresses alpha2beta1 integrin-dependent cell spreading through inhibition of Cdc42 activity. J Cell Physiol.