91猫先生

研究方向及研究室特色

探讨感染与代谢疾病中的粒线体品质管控分子机制
本实验室以一个核心科学问题作為研究主题：粒线体品质管控如何参与人类疾病的发生与进展？我们是否能将其转化為可行的治疗策略？我们致力於探讨自噬作用，尤其是粒线体自噬（尘颈迟辞辫丑补驳测）的动态调控机制，并将其视為细胞因应压力、感染与代谢失衡之关键基础机制。透过整合分子生物学、先进超微结构影像技术以及转译医学疾病模型，我们旨在阐明粒线体周转如何在不同病理情境下决定细胞命运与功能状态。
(一) 病毒与宿主交互作用：粒线体自噬作為前线调控枢纽如颁型肝炎病毒、登革病毒与兹卡病毒等病原体，会重塑宿主细胞内在环境以支持其复製与存活。我们聚焦於解析这些病毒如何操控自噬与粒线体自噬，藉以改变粒线体功能、逃避免疫监控并优化病毒增殖。透过剖析粒线体在抗病毒讯号传递与代谢重塑中的分子调控网络，我们期望揭示病毒感染致病机制的新层面，并开发崭新的抗病毒介入策略。
(二) MASLD与肝癌中的粒线体功能与粒线体自噬的失衡代谢功能异常相关脂肪性肝病（惭础厂尝顿）已成為全球迅速上升的重大公共卫生挑战，亦是肝细胞癌的重要前驱疾病。我们致力於探讨粒线体品质管控崩解如何驱动疾病从脂肪堆积进展至发炎、纤维化乃至恶性转化。透过具临床相关性的动物模型以及尖端超微结构影像平台，我们描绘惭础厂尝顿进程中粒线体的动态重塑过程，并鑑定具有治疗潜力的关键分子标的。
(叁) 粒线体自噬活化於临床治疗上的应用性恢復粒线体周转与品质管控，被视為对抗代谢性与退化性疾病的关键策略。本实验室运用高通量筛选平台与可靠的粒线体自噬分析系统，寻找能促进粒线体品质管控的小分子活化剂。我们的长期愿景，是将这些基础发现转化為安全且具机制导向的治疗方法，用以改善由粒线体功能失衡所驱动的人类疾病。
我们的使命阐明粒线体品质管控的基础生物学机制，并将其转化為创新的治疗策略，以应对病毒感染、代谢性肝病及其他相关疾病。

HONORS & ACADEMIC SERVICE

(I) AWARDS

1. 全球前 2% 顶尖科学家(World’s Top 2% Scientists) 获奖人(2021).
2. 长庚大学108年度优良教师奖(2019)
3. 科技部杰出学者养成计画 (MOST grant award for cultivation of outstanding young scholars，支持105~108叁年期研究計畫)获奖人
4. 国家卫生研究院 (NHRI)103年度Career Development Grant (CDG，支持103-107四年期研究计画)获奖人
5. 科技部补助大专校院奖励特殊优秀人才(2015)
6. 科技部补助大专校院奖励特殊优秀人才(2014)
7. Outstanding Paper Award on Hepatitis C Virus Research of Liver Disease Prevention & Treatment Research Foundation, Taiwan, R.O.C. (2011)
8. International Travel Fellowship and Invited Oral Presentation Award, 17th International Meeting on Hepatitis C Virus and Related Viruses (2011)
9. Research Article Competition Award for Post-Doctoral Research Fellow, Institution of Biomedical Sciences, Academia Sinica (2010)
10. Poster Outstanding Award, 18th Symposium on Recent Advances in Cellular and Molecular Biology (2010)
11. Poster Outstanding Award, 17th Symposium on Recent Advances in Cellular and Molecular Biology (2009)
12. The President Award in Medicine and Technology, Tien-Te Lee Biomedical
13. Foundation, Yung Shin PHARM. IND. CO., LTD (2005)
14. Post-doctoral Fellowship Award, National Health Research Institute (2005)
15. Outstanding Student Award in Academy, National Taiwan University (2004)
16. Dr. Chien-Tien Hsu Award in 12th Symposium on Recent Advances in Cellular and Molecular Biology (2004)
17. International Conference Travel Award, The Chinese Society of Cell and Molecular Biology (2003)
18. Excellent Publication Award for Graduate Student, National Taiwan University, College of Medicine (2003)

(II) ACADEMIC SERVICE

1. The editorial board member of Scientific Reports (SCI) (2019~)
2. The editorial board member of Pathogens (SCI) (2019~)
3. The editorial board member of Frontier in Microbiology (SCI) (2021~)
4. The reviewer board member of International Journal of Molecular Sciences (SCI) (2020~)
5. The reviewer board member of Cells (SCI) (2020~)
6. The reviewer board member of Microorganisms (SCI) (2020~)
7. The review board member of Welcome Trust Investigator Grant Award 2020 (UK) (2020)
8. The 9th International Symposium on Autophagy (2019) Organization Committee and Section Chair
9. The peer reviewer of research journals (SCI): Autophagy; Viruses; Apoptosis; Scientific Reports; Journal of Biomedical Sciences; Brain Research; Cell cycle; Biomedical Journal; Cellular Microbiology; IJMS; Cells; Cancers; Journal of Virology; PLoS ONE; BioMed Research International
10. The peer reviewer of research proposal and funding grant: Ministry of science and technology (MOST) research proposal; Chang Gung Memorial Hospital (CGMH) research proposal; Taipei Veterans General Hospital (TVGH) research proposal; Cheng Hsin General Hospital (CHGH) research proposal

(III) MEMBERSHIP

1. The Chinese Society of Cell and Molecular Biology (2001-present)
2. The American Society of Cell Biology (2004-present)
3. The International Conference of Hepatitis C Virus and Related Virus (2010-present)
4. The Gordon Research Conference: Autophagy (2014-present)
5. The International Symposium of Autophagy, Asia (2014-present)
6. Keystone Symposium in Molecular and Cellular Biology (2015-present)
7. Cold Spring Harbor Conferences, Asia (2015-present) 

GRNAT SUPPORT

1. 探索专一性粒腺体自噬作用在黄热病毒与宿主交互作用之生理角色(MOST 109-2320-B-182-010-MY3) (2020/8/1~2023/7/31) (NT$ 5,760,000), 补助机构: 科技部
2. 探讨人类DEAD-box helicase 3所导引之细胞自噬脂质分解作用於黄热病毒感染与宿主细胞交互作用之生理功能性角色(MOST 108-2320-B-182-011) (2019/8/1~2020/7/31) (NT$ 1,309,000), 补助机构: 科技部
3. 专一细胞自噬反应引发之选择性分解作用於调控病毒接受体分子与病毒感染力交互作用之功能性分析(MOST 105-2628-B-182-001-MY3) (2016/8/1~2019/7/31) (NT$ 4,295,000), 补助机构: 科技部
4. 探索C型肝炎病毒引发之专一选择性细胞自噬作用降解的分子以研究病毒与宿主细胞之交互作用, (NHRI-EX103 ~106-10322SC) (2014/1/1~2017/12/31) (NT$ 7,000,000), 补助机构: 国家卫生研究院
5. 细胞自噬分解作用於负向调控第一型干扰素反应之功能性分析, (MOST 102-2320-B-182-037-MY3) (2013/8/1~2016/7/31) (NT$ 6,528,000), 补助机构: 科技部
6. 探讨selective autophagy调控RLR抗病毒讯息传递之分子机转, (MOST 101-2320-B-182-043) (2012/8/1~2013/7/31) (NT$ 1,050,000), 补助机构: 科技部

Publication

1. Lin YJ, Huang LT, Ke PY, Chen GC, The deubiquitinase USP45 inhibits autophagy through actin regulation by Coronin 1B, Journal of Cell Biology, May, 2025, 224(5): e202407014.
2. Hsiao YC, Chang CW, Yeh CT and Ke PY*, Hepatitis C Virus NS5A Activates Mitophagy Through Cargo Receptor and Phagophore Formation, Pathogens, Dec, 2024, 13(12): 1139.
3. Ke PY* and Yeh CT, Functional Role of Hepatitis C Virus NS5A in the Regulation of Autophagy, Pathogens, Nov, 2024, 13(11): 980.
4. Wu CC, Tam EH, Shih YY, Lin YR, Hsueh PC, Shen HY, Woung CH, Wang LT, Tsai JC, Lin SJ, Chang CR, Ke PY, and Kuo RL, Exploration of influenza A virus PA protein-associated cellular proteins discloses its impact on mitochondrial function, Virus Research, Jul, 2024, 345: 199387.
5. Ke PY*, Regulation of Autophagosome-Lysosome Fusion by Human Viral Infections, Pathogens, Mar, 2024, 13(3): 266.
6. Ke PY*, Molecular Mechanism of Autophagosome-Lysosome Fusion in Mammalian Cells, Cells, Mar, 2024, 13(6): 500. 
7. Ke PY*, Crosstalk between Autophagy and RLR Signaling, Cells, Mar, 2023, 12(6): 956.
8. Liou LB, Wang TY, Liu IJ, Wu HC, Ke PY, Fang YF, Chen YF, α-2,6-sialic acid/IgG anti-dsDNA ratios correlate with human lupus disease activity and possible mechanisms: A pilot study, LUPUS, Jul, 2022, 31(8): 927-938.
9. Ke PY*, Chang CW, Hsiao YC, Baicalein Activates Parkin-Dependent Mitophagy through NDP52 and OPTN, Cells, Mar, 2022, 11(7): 1132.
10. Ke PY*, Autophagy and antiviral defense, IUBMB Life, Apr, 2022, 74(4): 317-338.
11. Peng HH, Wu CY, Hsiao YC, Martel J, Ke PY, Chiu CY, Liau JC, Chang IT, Su YH, Ko YF, Young JD, Ojcius DM, Ganoderma lucidum stimulates autophagy-dependent longevity pathways in Caenorhabditis elegans and human cells, Aging-us, May, 2021, 13(10): 13474-13495.
12. Klionsky DJ et al, and Ke PY, and 2290 authors, Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition), Autophagy, Jan, 2021, 17(1): 1-382.