91猫先生

研究方向及研究室特色

利用基因工程的方式来研究特定基因在活体内的功能，是现今研究的一个重要工具。然而，除了在生化及生理上的改变之外，目前更重要的趋势是将其功能与临床上的病症相结合，以期达到促进健康的终极目标。因此我们利用操纵小鼠基因，观察其对特定疾病过程产生的影响。除了瞭解特定生理生化上的功能影响之外，我们更着重於观察因基因改变造成之受损组织或器官所产生的形态上改变。将组织或器官切片，以各种不同方式观察其型态与特定分子的改变，以期与临床上的特定病理状态作结合。

1. Effect of Pnn on the regulation of alternative splicing in brain
2. Protective effects of conditioned medium on myocardial infarction
3. Regulation of genes on the proliferation and migration of cancer cells

最近五年所发表论文

1. Ke-Hung Tsui, Kang-Shuo Chang, Hsin-Ching Sung, Shu-Yuan Hsu, Yu-Hsiang Lin, Chen-Pang Hou, Pei-Shan Yang, Chien-Lun Chen, Tsui-Hsia Feng, Horng-Heng Juang. Mucosa-Associated Lymphoid Tissue 1 Is an Oncogene Inducing Cell Proliferation, Invasion, and Tumor Growth via the Upregulation of NF-κB Activity in Human Prostate Carcinoma Cells. Biomedicines, 2021, 9, 250-265

2. SY Hsu, S Mukda, S Leu. Expression and Distribution Pattern of Pnn in Ischemic Cerebral Cortex and Cultured Neural Cells Exposed to Oxygen-Glucose Deprivation. Brain Sciences, 2020, 10 (10), 708

3. KC Chiang, KS Chang, SY Hsu, HC Sung, TH Feng, M Chao, HH Juang. Human Heme Oxygenase-1 Induced by Interleukin-6 via JAK/STAT3 Pathways Is a Tumor Suppressor Gene in Hepatoma Cells. Antioxidants, 2020, 9 (3), 251

4. Chen, C.-H.*; Hsu, S.-Y.*; Chiu, C.-C.; Leu, S. MicroRNA-21 Mediates the Protective Effect of Cardiomyocyte-Derived Conditioned Medium on Ameliorating Myocardial Infarction in Rats. Cells 2019, 8, 935

5. S Leu, SY Hsu, P Ouyang. 4260 Loss of Pnn in cardiomyocytes results in impairment of intercalated discs and arrhythmogenic cardiomyopathy in mice. European Heart Journal, 2019, 40 (Supplement_1), ehz745. 0138

6. HY Shih, SY Hsu, P Ouyang, SJ Lin, TY Chou, MC Chiang, YC Cheng. Bmp5 regulates neural crest cell survival and proliferation via two different signaling pathways. Stem Cells, 2017, 35 (4), 1003-1014

7. Yi-Chih Chang*, Shu-Yuan Hsu*, Chih-Chao Yang, Pei-Hsun Sung, Yi-Ling Chen, Tien-Hung Huang, Gour-Shenq Kao, Sheng-Yi Chen, Kuan-Hung Chen, Hsin-Ju Chiang, Hon-Kan Yip, Fan-Yen Lee. Enhanced protection against renal ischemia–reperfusion injury with combined melatonin and exendin-4 in a rodent model. Experimental Biology and Medicine, 2016, 241 (14), 1588-1602

8. Kun-Chun Chiang*, Shu-Yuan Hsu*, Sheng-Jia Lin, Chun-Nan Yeh, Jong-Hwei S Pang, Shang-Yu Wang, Jun-Te Hsu, Ta-Sen Yeh, Li-Wei Chen, Sheng-Fong Kuo, Yi-Chuan Cheng, Horng-Heng Juang. PTEN insufficiency increases breast cancer cell metastasis in vitro and in vivo in a xenograft zebrafish model. Anticancer research, 2016, 36 (8), 3997-4005

9. HT Chai, HK Yip, CK Sun, SY Hsu, S Leu. AG490 suppresses EPO-mediated activation of JAK2-STAT but enhances blood flow recovery in rats with critical limb ischemia. Journal of inflammation, 2016, 13 (1), 1-11

10. Sheung-Fat Ko*, Shu-Yuan Hsu*, Chih-Hung Chen, Pei-Hsun Sung, Meng-Shen TongYen-Yi Zhen, Yi-Ling Chen, Tien-Hung Huang, Sheng-Yi Chen, Gour-Shenq Kao, Hong-Hwa Chen, Chia-Lo Chang, Cheuk-Kwan Sun, Hsueh-Wen Chang, Hon-Kan Yip. Human lung cancer-derived microparticles enhanced angiogenesis and growth of hepatoma cells in rodent lung parenchyma. American journal of translational research, 2016, 8 (3), 1302