91猫先生

研究方向及研究室特色：

人脑创造了许多高科技的产物，甚至建造了超级电脑，可是我们对自己脑是如何运作的却依旧非常地模糊。揭开大脑是如何运作是一个令人着迷的问题，本实验室目前的研究主题主要是专注在情绪焦虑，认知学习记忆，生理运动，脑创伤和脑中风方面。研究的方法主要是以小鼠的动物模式，来探讨基因，脑神经细胞结构，生理贺尔蒙与动物行為，希望藉此来试着解开基因与神经的运作之谜。

目前实验室的研究有以下几个议题:

1) 个体成年后，脑中增生的新神经细胞其生理上的功能為何?
2) 運動如何讓腦神經細胞更健康，是透過如何機制？
3) 要如何讓年老的神經細胞年輕化？有哪些可能的候選因子？
4) 利用基因治療來修復腦創傷或是腦中風?

最近五年所发表论文：

Selected Publications:  (*corresponding author)     

1. Chen YJ, Deng SM, Chen HW, Tsao CH, Chen WT, Cheng SJ, Huang HS, Tan BC, Matzuk MM, Flint J, Huang GJ*. Follistatin mediates learning and synaptic plasticity via regulation of Asic4 expression in the hippocampus. Proceedings of the National Academy of Sciences of the United States of America 2021 Sep 28;118(39):e2109040118.

2. Eu WZ, Chen YJ, Chen WT, Wu KU, Tsai CY, Cheng SJ, Carter R, Huang GJ*. The effect of nerve growth factor on supporting spatial memory depends upon hippocampal cholinergic innervations. Translational Psychiatry 2021 Mar 15;11(1):162
3. Chang S, Bok P, Tsai, CY, Sun CP, Liu H, Deussing  JM, Huang GJ*. NPTX2 is a key component in the regulation of anxiety. Neuropsychopharmacology 2018 Aug;43(9):1943-1953
4. Chang S, Bok P, Sun CP, Edwards A, Huang GJ*. Neuropsin inactivation has protective effects against depressive-like behaviours and memory impairment induced by chronic stress. PLoS Genetics 2016 Oct 4; 12(10): e1006356 
5. Tsai CY, Tsai CY, Arnold S, Huang GJ*. Ablation of hippocampal neurogenesis in mice impairs the response to stress during the dark cycle. Nature Communications 2015 Sep 29;6:8373. doi: 10.1038/ncomms9373. 
6. Cai N, et al., Molecular signatures of major depression. Current Biology 2015 May 4;25(9):1146-56. (co-senior author) 
7. Huang GJ, Smith AL, Gray DH, Cosgrove C, Singer BH, Edwards A, Sims S, Parent JM, Johnsen A,Mott R, Mathis D, Klenerman P, Benoist C, Flint J. A genetic and functional relationship between T-cells and cellular proliferation in the adult hippocampus. PLoS Biology 2010 Dec 14; 8(12):e1000561 
8. Huang GJ, Shifman S, Johannesson M, Yalcin B, Valdar W, Taylor J, Mott R, Flint J. High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues. Genome Research 2009 Jun; 19(6):1133-40  
9. Arnold S, Huang GJ (equal contribution), Cheung A, Era T, Nishikawa SI, Bikoff E, Molnar E, Robertson E, Groszer M. The T-box transcription factor Tbr2/Eomes regulates neurogenesis in the cortical subventricular zone. Genes & Development 2008 Sep 15; 22(18):2479-84 
10. Huang GJ*, Bannerman D, Flint J. Chronic fluoxetine treatment alters behaviour, but not adult hippocampal neurogenesis, in BALB/cJ mice. Molecular Psychiatry 2008 Feb; 13, 119-121. 
11. Huang GJ, Herbert J. Stimulation of neurogenesis in the dentate gyrus of the adult rat by fluoxetine requires rhythmic change in corticosterone. Biological Psychiatry 2006 Apr 1; 59(7):619-24 
12. Huang GJ, Herbert J. Serotonin modulates the suppressive effects of corticosterone on proliferating progenitor cells in the dentate gyrus of the hippocampus in the adult rat. Neuropsychopharmacology 2005 Feb 30:231-241