傅崇安 / Sebastian D. Fugmann
职称： 教授
现职： 长庚大学
电话： 03-211-8800 ext. 3478
学歷： 德国乌尔姆大学博士
专长领域： 发育生物学;免疫学;(多)体学或系统生物学;Evolutionary Biology
个人网页：
个人网页
研究方向及研究室特色：
免疫系统在有微生物入侵时，会啟动且整合相关的抵御机制。有趣的是，共生菌是有益宿主的，但病原菌则会造成宿主的疾病甚至死亡，因此是宿主的免疫反应攻击的对象。免疫力的核心机制，有吞噬作用(由巨噬细胞等负责)和毒杀作用(由各类杀手细胞进行)等。我们感兴趣的，是动物的免疫系统，如何凭藉不同的因子，让各式免疫细胞能够灵活运用这两种关键的机制以达到防御健康的效果。我们主要研究的对象是海洋无脊椎动物，例如紫海胆、美丽海葵、海豆芽等及其共生菌。近期我们在这个领域的研究即发现，在具有后天免疫物种中负责製造高亲和力抗体的酵素，在无脊椎动物中就已经存在了!
最近五年所发表论文：
1.) Trajectory mapping of the early Drosophila germline reveals controls of zygotic activation and sex differentiation. Li YR, Lai HW, Huang HH, Chen HC, Fugmann SD, Yang SY. Genome Res. 2021 Apr 15:gr.271148.120. doi: 10.1101/gr.271148.120. 2018
2.) AID/APOBEC-like cytidine deaminases are ancient innate immune mediators in invertebrates. Liu MC, Liao WY, Buckley KM, Yang SY, Rast JP, Fugmann SD. Nat Commun. 2018 May 16;9(1):1948. doi: 10.1038/s41467-018-04273-x.
3.) Lectins identify distinct populations of coelomocytes in Strongylocentrotus purpuratus. Liao WY, Fugmann SD. PLoS One. 2017 Nov 10;12(11):e0187987. doi: 10.1371/journal.pone.0187987.
4.) Evidence for parallel evolution of a gene involved in the regulation of spermatogenesis. Wang XR, Ling LB, Huang HH, Lin JJ, Fugmann SD, Yang SY. Proc Biol Sci. 2017 May 31;284(1855):20170324. doi: 10.1098/rspb.2017.0324.
5.) Collaboration of RAG2 with RAG1-like proteins during the evolution of V(D)J recombination. Carmona LM, Fugmann SD, Schatz DG. Genes Dev. 2016 Apr 15;30(8):909-17. doi: 10.1101/gad.278432.116.
6.) The identification of a novel SIRT6 modulator from Trigonella foenum-graecum using ligand fishing with protein coated magnetic beads. Singh N, Ravichandran S, Spelman K, Fugmann SD, Moaddel R. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Oct 1;968:105-11. doi: 10.1016/j.jchromb.2014.03.016.
7.) Form follows function - the three-dimensional structure of antigen receptor gene loci. Fugmann SD. Curr Opin Immunol. 2014 Apr;27:33-7. doi: 10.1016/j.coi.2014.01.011.
8.) Pharmacophore model of the quercetin binding site of the SIRT6 protein. Ravichandran S, Singh N, Donnelly D, Migliore M, Johnson P, Fishwick C, Luke BT, Martin B, Maudsley S, Fugmann SD, Moaddel R. J Mol Graph Model. 2014 Apr;49:38-46. doi: 10.1016/j.jmgm.2014.01.004.
9.) Synthesis and characterization of a SIRT6 open tubular column: predicting deacetylation activity using frontal chromatography. Singh N, Ravichandran S, Norton DD, Fugmann SD, Moaddel R. Anal Biochem. 2013 May 15;436(2):78-83. doi: 10.1016/j.ab.2013.01.018.
10.) Transcription, splicing, and release: are we there yet? Sen R, Fugmann SD. Cell. 2012 Jul 20;150(2):241-3. doi: 10.1016/j.cell.2012.07.004.
11.) Synthesis and characterization of SIRT6 protein coated magnetic beads: identification of a novel inhibitor of SIRT6 deacetylase from medicinal plant extracts.
Yasuda M, Wilson DR, Fugmann SD, Moaddel R. Anal Chem. 2011 Oct 1;83(19):7400-7. doi: 10.1021/ac201403y.
12.) Separation of mutational and transcriptional enhancers in Ig genes. Kothapalli NR, Collura KM, Norton DD, Fugmann SD. J Immunol. 2011 Sep 15;187(6):3247-55. doi: 10.4049/jimmunol.1101568.