91猫先生

研究方向及研究室特色:

本研究室以转译医学与药理学為核心，致力於从临床问题寻找新的疾病机转与治疗策略。研究领域涵盖高血压、急性肾损伤及慢性肾臟病，并结合临床检体、细胞与动物疾病模式，探讨疾病进展的重要讯号路径及潜在治疗标的。研究室亦积极发展干细胞衍生细胞外囊泡於肾臟损伤与组织修復的应用，并运用转录体、蛋白质体及分子药理技术解析其作用机转。我们特别重视「从临床发现到实验验证，再回到治疗与诊断应用」的转译研究模式，学生可实际参与临床转译、分子生物学、动物实验及新药标的研究，培养独立思考及跨领域研究能力。

最近五年所發表論文: (*, Corresponding author):

1.          Kang-Yung Peng^#, Ssu-Ju Fu^#, Chih-Yung Tang et al. Novel gain-of-function CLCN2 germline mutation associated with nonclassical lateralizing primary aldosteronism. J Mol Endocrinol. 2026;77(1):e250176.

2.          Che-Hsiung Wu, Kang-Yung Peng, Vin-Cent Wu et al. KCNJ5-Negative Primary Aldosteronism: Histopathology and Surgical Outcomes. Hypertension. 2026;83(5):e26266.

3.          Vin-Cent Wu, Kang-Yung Peng, Jeff S Chueh et al. Carboxyl-terminal FGF-23 Production Coupling with Aldosterone via FAM20C and Predicting Cardiovascular Events in Primary Aldosteronism. JCI Insight. 2025;10(4):e166461.

4.          Chu-Wen Fang, Kang-Yung Peng*, Jeff S Chueh* et al. A comparative study of postadrenalectomy hyperuricemia and renal impairment in patients with unilateral primary aldosteronism: does histopathology subtype matter? BMC Nephrol. 2024;25(1):347.

5.     Kang-Yung Peng^#, Chi-Shin Tseng^#, Jeff S. Chueh et al. A Novel Somatic Mutation of CACNA1H p.V1937M in Unilateral Primary Hyperaldosteronism. Frontiers in Endocrinology. 2022 Jun 9;13:816476.

6.     Vin-Cent Wu, Kang-Yung Peng, Jeff S Chueh et al. Histopathologically Classical Aldosterone- Producing Adenomas Yield Various Transcriptomic Signaling and Outcomes. Hypertension. 2021;78(6):1791-1800. 

7.     Kang-Yung Peng, Hung-Wei Liao, Vin-Cent Wu et al. Pathophysiological and Pharmacological Characteristics of KCNJ5 157-159delITE Somatic Mutation in Aldosterone-Producing Adenomas. Biomedicines. 2021;9(8):1026.

8.     Kang-Yung Peng, Hung-Wei Liao, Vin-Cent Wu et al. Presence of Subclinical Hypercortisolism in Clinical Aldosterone-Producing Adenomas Predicts Lower Clinical Success. Hypertension. 2020;76(5):1537-1544.