91猫先生

Research Topics

1. Development of Life-Extending Drugs
2. Preparation of Reference Standards for Chinese Herbal Medicines

Patents

1. Wang, Rui-Yu; Jun, Kan; and Lu, Yen-Li.
   Patent Title: A Skin-Whitening Composition
   Taiwan Patent No.: I302102
   Patent Term: 2008.10.21–2026.03.05
2. Ko, Yun-Fei; Ma, Yi-An; Liao, Jian-Qing; Jian, Wei-Ting; Chang, Yi-Te; Chiu, Chen-Yao; Lu, Yen-Li; Wu, Tsung-Ju; Huang, Tsung-Teng; Lu, Chia-Chen; David Ou; Lai, Hsin-Chih; and Yang, Ding-Yi.
   Patent Title: Compounds Isolated from Antrodia cinnamomea, Methods for Preparing the Same, and Uses Thereof
   Taiwan Patent No.: I538674
   Patent Term: 2016.06.21–2034.07.13
3. Chen, Jin-Chyuan; Lu, Yen-Li; Huang, Tsung-Lung; Fang, Chia-You; and Pan, Tai-Lung.
   Patent Title: Activators of Mammalian SIRT1
   Taiwan Patent No.: I556818
   Patent Term: 2016.11.11–2035.08.06
4. Ma, Yun-Hua; Lu, Yen-Li; Wu, Chien-Te; Wei, Kuo-Chen; and Lu, Yi-Ching.
   Patent Title: Mixture for Enhancing Cellular Uptake of Particles and Method for Preparing the Same
   Taiwan Patent No.: I583395
   Patent Term: 2017.05.21–2032.05.21
5. Chen, Jin-Chyuan; Lu, Yen-Li; and Wang, Shu-Hui.
   Patent Title: Inhibitors of Mammalian TOR
   Taiwan Patent No.: I586351
   Patent Term: 2017.06.11–2036.02.15
6. Li, Tsung-Yen; Chang, Heng-Hung; Lu, Yen-Li; Liu, Hsuan-Miao; Chiang, Wei-Han; and Wang, Cheng-Hui.
   Patent Title: Pharmaceutical Composition and Its Use in the Treatment of Parkinson’s Disease
   Taiwan Patent No.: I770608
   Patent Term: 2022.07.11–2040.09.10

Honors and Awards

Laboratory Members and Activity Photos

Publications

1.Tsung-Ru Wu, Tsung-Teng Huang, Jan Martel, Jian-Ching Liaug, Chen-Yaw Chiu, Yann-Lii Leu, Wei-Ting Jian, I-Te Chang, Chia-Chen Lu, David M. Ojcius, Yun-Fei Ko, Hsin-Chih Lai, John D. Young “Pinicolol B from Antrodia cinnamomea induces apoptosis of nasopharyngeal carcinoma cells”&苍产蝉辫;Journal of Ethnopharmacology, 201, 117-122 (2017).

2. Sin-Guang Chen, Mei-Ling Cheng, Kuan-Hsing Chen, Jim-Tong Horng, Ching-Chuan Liu, Shih-Min Wang, Hiroaki Sakurai, Yann-Lii Leu, Shulhn-Der Wang, Hung-Yao Ho “Antiviral activities of Schizonepeta tenuifolia Briq. against enterovirus 71 in vitro and in vivo” Scientific Reports | 7:935 | DOI: 10.1038 /s41598-017-01110-x (2017).

3. Sin-Guang Chen, Yann-Lii Leu, Mei-Ling Cheng, Siew Chin Ting, Ching-Chuan Liu, Shulhn-Der Wang, Cheng-Hung Yang, Cheng-Yu Hung, Hiroaki Sakurai, Kuan-Hsing Chen, Hung-Yao Ho  “Anti-enterovirus 71 activities of Melissa officinalis extract and its biologically active constituent rosmarinic acid”&苍产蝉辫;Scientific Reports | 7:12264 | DOI:10.1038/s41598-017-12388-2 (2017).

4. Tzung-Yan Lee*, Yann-Lii Leu* and Chorng-Kai Wen “Modulation of HIF-1α  and STAT3 signaling contributes to anti-angiogenic effect of YC-1 in mice with liver fibrosis”&苍产蝉辫;Oncotarget, 8, 86206-86216 (2017)

5. Chung-Ju Yeh, Chin-Chuan Chen, Yann-Lii Leu, Ming-Wei Lin, Mei-Miao Chiu, Shu-Huei Wang “The effects of artocarpin on wound healing: in vitro and in vivo 蝉迟耻诲颈别蝉”&苍产蝉辫;Scientific Reports | 7:15599 | DOI:10.1038/s41598-017-15876-7 (2017).

6. Chin-Chuan Chen, Ju-Sui Huang, Tong-Hong Wang, Chen-Hsin Kuo, Chia-Jen Wang, Shu-Huei Wang,* and Yann-Lii Leu* “Dihydrocoumarin, an HDAC inhibitor, increases DNA damage sensitivity by inhibiting Rad52”&苍产蝉辫;International Journal Molecular Sciences, 18, 2655-2672 (2017).

7. Yu-Hsuan Lan, Hsiu-Hui Chan, Chuan-Nien Chuang, Tran-Dinh Thang, Yann-Lii Leu* “Three new chemical constituents of Korthalsella japonica”&苍产蝉辫;Phytochemistry Letters, 23, 132-136 (2018).

8. Jih-Tung Pai, Yi-Chin Lee, Si-Ying Chen, Yann-Lii Leu*, Meng-Shih Weng* “Propolin C inhibited migration and invasion via suppression of EGFR-mediated epithelial-to-mesenchymal transition in human lung cancer cells”&苍产蝉辫;Evidence-Based Complementary and Alternative Medicine, Article ID 7202548, 15 pages (2018).

9. Chi-Yuan Chen, Chin-Chuan Chen, Tzong-Ming Shieh, Chuen Hsueh, Shu-Huei Wang, Yann-Lii Leu, Jang-Hau Lian and Tong-Hong Wan* “Corylin suppresses hepatocellular carcinoma progression via the inhibition of epithelial-mesenchymal transition, mediated by long noncoding RNA GAS5”&苍产蝉辫;International Journal Molecular Sciences, 19, 380-392 (2018).

10. Ahmed Alalaiwe, Chi-Feng Hung, Yann-Lii Leu, Kohei Tahara, Hi-Han Chen, Kai-Yin Hu and Jia-You Fang* “The active compounds derived from Psoralea corylifolia for photochemotherapy against psoriasis-like lesions: The relationship between structure and percutaneous absorption”&苍产蝉辫;European Journal of Pharmaceutical Sciences, 124, 114-126 (2018).

11. Hung-Yuan Li1, Yann-Lii Leu1, Ya-Chieh Wu, Shu-Huei Wang* “Melatonin inhibits in vitro smooth myscle cell inflammation and proliferation and atherosclerosis in apolipoprotein E-deficient mice”&苍产蝉辫;Journal of Agricultural and Food Chemistry, 67, 1889-1901 (2019)

12. Chin-Chuan Chen, Ting-Yau Lee, Yann-Lii Leu and Shu-Huei Wang* “Pigment epithelium-derived factor inhibits adipogenesis in 3T3-L1 adipocytes and protects against high-fat diet-induced obesity and metabolic disorders in mice” Translational Research, 210, 26-42 (2019).

13. Po-Jen Chen, I-Ling Ko, Chia-Lin Lee, Hao-Chun Hu, Fang-Rong Chang, Yang-Chang Wu, Yann-Lii Leu, Chih-Ching Wu, Cheng-Yu Lin, Chang-Yu Pan, Yung-Fong Tsai and Tsong-Long Hwang* “Targeting allosteric site of AKT by 5,7-dimethoxy-1,4-phenanthrenequinone suppresses neutrophilic inflammation”&苍产蝉辫;EBioMedicine, 40, 528-540 (2019).

14. Yi-Hsuan Lin, Helen Luck, Saad Hhan, Pierre H, H, Schneeberger, Sue Tsai, Xavier Clemente-Casares, Helena Lei, Yann-Lii Leu, Yi-Tao Chan, Hsing-Yu Chen, Sien-Hung Yang, Bryan Cobum, Shawn Winer, Daniel A, Winer* “Aryl hydrocarbon receptor agonist indigo protects against obesity-related insulin resistance through modulation of intestinal and metabolic tissue immunity”&苍产蝉辫;International Journal of Obesity, 2019 Apr 3. doi: 10.1038/s41366-019-0340-1

15. Chen-Hsin Kuo1, Yann-Lii Leu1, Tong-Hong Wang, Wei-Che Tseng, Chun-Hao Feng, Shu-Huei Wang, Chin-Chuan Chen “A novel DNA repair inhibitor, diallyl disulfide (DADS), impairs DNA resection during DNA double-strand break repair by reducing Sae2 and Exo1 levels”&苍产蝉辫; DNA repair, 82, 102690-102700 (2019).

16. Tong-Hong Wang1, Yann-Lii Leu1, Chin-Chuan Chen, Tzong-Ming Shieh, Jang-Hau Lian, Chi-Yuan Chen* “Psorachromene suppresses oral squamous cell carcinoma progression by inhibiting long non-coding RNA GAS5 mediated epithelial-mesenchymal transition” Frontiers in Oncology, 9, article 1168 (2019).

17. H.N. Li, C.Y. Wang, C.L. Wang, C.H. Chou, Yann-Lii Leu, B.Y. Chen “Antimicrobial effects and mechanisms of ethanol extracts of Psoralea corylifolia seeds against Listeria monocytogenes and methicillin-resistant Staphylococcus aureus”&苍产蝉辫;Foodborne Pathogens and Disease, 16, 573-580 (2019).

18. Li-Fang Chou, Chi-Yuan Chen, Wan-Hua Yang, Chin-Chuan Chen, Junn-Liang Chang, Yann-Lii Leu, Miaw-Jene Liou, Tong-Hong Wang* “Suppression of hepatocellular carcinoma progression through FOXM1 and EMT inhibition via hydroxygenkwanin-induced miR-320a expression”&苍产蝉辫;Biomolecules, 10, 20-34 (2020)

19. Chi-Yuan Chen, Chi-Chuan Chen, Wen-Yu Chung, Yann-Lii Leu, Shir-Hwa Ueng, Chuen Hsueh, Chau-Ting Yeh*, Tong-Hong Wang* “Hydroxygenkwanin inhibits class I HDAC expression and synergistically enhances the antitumor activity of Sorafenib in liver cancer cells”&苍产蝉辫;Frontiers in Oncology, 10, article 216 (2020).

20. Yann-Lii Leu1, Tong-Hong Wang1, Chin-Ching Wu, Kuo-Yen Huang, Yu-Wen Jiang, Yi-Chiung Hsu*, Chi-Yuan Chen* “Hydroxygenkwanin suppression non-small cell lung cancer progression by enhancing EGFR degradation”&苍产蝉辫;Molecules, 25, 941-952 (2020)

21. Yu-Hsuan Lan *, Chia-Hung Yen, Yann-Lii Leu* “Chemical constituents from the aerial parts of Euphorbia formosana Hayata and their chemotaxonomic significance”&苍产蝉辫;Biochemical Systematics and Ecology, 88, 103967 (2020)

22. Chin-Chuan Chen, Hung-Yuan Li, Yann-Lii Leu, Yu-Ju Chen, Chia-Jen Wang, Shu-Huei Wang* “Corylin inhibits vascular cell inflammation, proliferation and migration and reduces atherosclerosis in ApoE-deficient mice”&苍产蝉辫;Antioxidants, 9, 275 (2020)

23. Chi-Yuan Chen, Jia-You Fang, Chi-Chuan Chen, Wen-Yu Chung, Yann-Lii Leu, Shir-Hwa Ueng, Li-Shan Wei, Shu-Fang Cheng, Chuen Hsueh, Tong-Hong Wang* “2-O-Methylmagnolol, a magnolol derivative, suppresses hepatocellular carcinoma progression via inhibiting class I histone deacetylase expression”&苍产蝉辫;Frontiers in Oncology, 10, article 1319 (2020).

24. Chien-Chung Yang, Li-Der Hsiao, Hsin-Hui Lin, Hui-Ching Tseng, Jiro Hasegawa Situmorang, Yann-Lii Leu, Chuen-Mao Yang* “Induction of HO-1 by 5, 8-dihydroxy-4’, 7-dimethoxyflavone via activation of ROS/p38 MAPK/Nrf2 attenuates thrombin-induced connective tissue growth factor expression in human cardiac fibroblasts”&苍产蝉辫;Oxidative Medicine and Cellular Longevity, 2000, article ID 1080168, 18 pages (2020)

25. Tong-Hong Wang, Chih-Ching Wu, Kuo-Yen Huang, Yann-Lii Leu, Shuenn-Chen Yang, Ci-Ling Chen, Chi-Yuan Chen “Integrated omics analysis of non-small-cell lung cancer cells harboring the EGFR C797S mutation reveals the potential of AXL as a novel therapeutic target in TKI-resistant lung cancer”&苍产蝉辫;Cancers, 13, 111-126 (2021)

26. Chin-Chuan Chen, Chen-Hsin Kuo, Yann-Lii Leu, Shu-Huei Wang “Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and b3-AR activation”&苍产蝉辫;Pharmacological Research, 164, 105291 (2021)

27. Yung-Fong Tsai, Chun-Yu Chen, I-Wen Lin, Yann-Lii Leu, Shum-Chin Yang, Yu-Ting Syu, Po-Jen Chen, Tsong-Long Hwang “Imperatorin alleviates psoriasiform dermatitis by blocking neutrophil respiratory burst, adhesion, and chemotaxis through selective phosphodiesterase 4 inhibition”&苍产蝉辫; Antioxidants & Redox Signaling, 35, 885-903 (2021).

28. Kuo-Yen Huang, Tong-Hong Wang, Chin-Chuan Chen, Yann-Lii Leu, Hsin-Jung Li, Cai-Ling Jhong, Chi-Yuan Chen, “Growth suppression in lung cancer cells harboring EGFR-C797S mutation by quercetin”&苍产蝉辫; Biomolecules, 11, 1271-1282 (2021).

29. Chin-Chuan Chen, Chi-Yuan Chen, Shu-Fang Cheng, Tzing-Ming Shieh, Yann-Lii Leu, Wen-Yu Chuang, Kuang-Ting Liu, Shir-Hwa Ueng, Yin-Hwa Shih, Li-Fang Chou, Tong-Hong Wang “Hydroxygenkwanin increase the sensitivity of liver cancer cells to chemotherapy by inhibiting DNA damage response in mouse xenograft models”&苍产蝉辫; International Journal of Molecular Sciences, 22, 9766-9784 (2021).

30. Jih-Tung Pai, Ming-Wei Hsu, Yann-Lii Leu, Kuo-Ting Chang, Meng-Shih Weng “Induction of G2/M cell cycle arrest via p38/p21Waf1/Cip1-dependent signaling pathway activation by bavachinin in non-small-cell lung cancer cells”&苍产蝉辫;Molecules, 26, 5161-5172 (2021).

31. Tong-Hong Wang, Chin-Chuan Chen, Yann-Lii Leu, Yun-Shien Lee, Jang-Hau Lian, His-Lung Hsieh, Chi-Yuan Chen “Palbociclib induces DNA damage and inhibits DNA repair to induce cellular senescence and apoptosis in oral squamous cell carcinoma”&苍产蝉辫; Journal of the Formosan Medical Association, 120, 1695-1705 (2021).

32. Jih-Tung Pai, Xing-Han Chen, Yann-Lii Leu, Meng-Shih Weng “Propolin G-suppressed epithelial-to-mesenchymal transition in triple-negative breast cancer cells via glycogen synthase kinase 3β-mediated snail and HDAC6-regulated vimentin degradation”&苍产蝉辫; International Journal of Molecular Sciences, 23, 1672-1700 (2022).

33. Zi-Yu Chang, Hsuan-Miao Liu, Yann-Lii Leu, Chung-Hua Hsu, Tzung-Yan Lee “Modulation of gut microbiota combined with upregulation of intestinal tight junction explains anti-inflammatory effect of corylin on colitis-associated cancer in mice”&苍产蝉辫;International Journal of Molecular Sciences, 23, 2667-2693 (2022).

34. Tong-Hong Wang,1 Yann-Lii Leu,1 Chin-Chuan Chen, Hsin-Jung Li, Shuenn-Chen Yang, Kuo-Yen Huang, Chi-Yuan Chen “Psorachromene induces apoptosis and suppresses tumor growth in NSCLC cells harboring EGFR L858R/T790M/C797S”

Phytotherapy Research, 2022, 1–11 (2022), DOI: 10.1002/ptr.7432

35. Tong-Hong Wang,1 Wei-Che Tseng,1 Yann-Lii Leu,1 Chi-Yuan Chen, Wen-Chih Lee, Ying-Chih Chi, Shu-Fang Cheng, Chun-Yu Lai, Chen-Hsin Kuo, Shu-Ling Yang, Sien-Hung Yang, Jiann-Jong Shen, Chun-Hao Feng, Chih-Ching Wu,  Tsong-Long Hwang, Chia-Jen Wang, Shu-Huei Wang, Chin-Chuan Chen “The flavonoid corylin exhibits lifespan extension properties in mouse”&苍产蝉辫;Nature Communications, 13, 1238-1254 (2022). 

36. Yu-Hsuan Lan, I-Hsiao Chen, Hsin-Hung Lu, Ting-Jing Guo, Tsong-Long Hwang, Yann-Lii Leu* “Euphormins A and B, new pyranocoumarin derivatives from Euphorbia formosana Hayata, and their anti-inflammatory activity”&苍产蝉辫;Molecules, 27, 1885-1895 (2022)

37. Ching?Chuan Yeh, Hsuan?Miao Liu, Ming?Chung Lee , Yann?Lii Leu, Wei?Han Chiang, Hen?Hong Chang, Tzung?Yan Lee “Phytochemical?rich herbal formula ATG?125 protects against sucrose?induced gastrocnemius muscle atrophy by rescuing Akt signaling and improving mitochondrial dysfunction in young adult mice”&苍产蝉辫; Molecular Medicine Reports, 25 (57), 1-20 (2022)

38. Hsiang-Ruei Liao, Yu-Yao Kao, Yann-Lii Leu, Fu-Chao Liu, Ching-Ping Tseng “Larixol inhibits fMLP-induced superoxide anion production and chemotaxis by targeting the βγ subunit of Gi-protein of fMLP receptor in human neutrophils”Biochemical Pharmacology, 201, 1-11 (2022) https://doi.org/10.1016/j.bcp.2022.115091