91猫先生

徐淑媛(Shu-Yuan Hsu)

职称：副教授

研究室名称：细胞生物学实验室

最高学歷：Ph.D.

学校/国家：长庚大学生物醫學研究所/台湾

分机号码：5088

电子邮件帐号： hsusy@mail.cgu.edu.tw

个人网页网址：

研究室现有： 博士后研究员   人

博士班研究生    人

硕士班研究生 人

专任研究助理    人

大学部专题生     人

研究方向及研究室特色：

利用基因工程的方式来研究特定基因在活体内的功能，是现今研究的一个重要工具。然而，除了在生化及生理上的改变之外，目前更重要的趋势是将其功能与临床上的病症相结合，以期达到促进健康的终极目标。因此我们利用操纵小鼠基因，观察其对特定疾病过程产生的影响。除了瞭解特定生理生化上的功能影响之外，我们更着重於观察因基因改变造成之受损组织或器官所产生的形态上改变。将组织或器官切片，以各种不同方式观察其型态与特定分子的改变，以期与临床上的特定病理状态作结合。

(1)               Effect of Pnn on the regulation of alternative splicing in brain

(2)               Protective effects of conditioned medium on myocardial infarction

(3)               Regulation of genes on the proliferation and migration of cancer cells

最近五年所发表论文：

1. Kang-Shuo Chang, Syue-Ting Chen, Shu-Yuan Hsu, Hsin-Ching Sung, Wei-Yin Lin, Ke-Hung Tsui , Yu-Hsiang Lin, Chen-Pang Hou and Horng-Heng Juang. Antioxidant Role by Inducing HO-1 Expression, Is C-X-C Motif Chemokine Receptor 2-Dependent in Human Prostate Stroma and Cancer Cells. Antioxidants 2024, 13:1489

2. Syue‐Ting Chen, Kang‐Shuo Chang, Yu‐Hsiang Lin, Chen‐Pang Hou, Wei‐Yin Lin, Shu‐Yuan Hsu, Hsin‐Ching Sung, Tsui‐Hsia Feng, Ke‐Hung Tsui, Horng‐Heng Juang. Glucose Upregulates ChREBP via Phosphorylation of AKT and AMPK to Modulate MALT1 and WISP1 Expression. Journal of Cellular Physiology 2024, 10:1

3. Syue-Ting Chen, Kang-Shuo Chang, Wei-Yin Lin, Shu-Yuan Hsu, Hsin-Ching Sung, Yu-Hsiang Lin, Tsui-Hsia Feng, Chen-Pang Hou, Horng-Heng Juan. Activating transcription factor 3 is an antitumor gene synergizing with growth differentiation factor 15 to modulate cell growth in human bladder cancer. Biomedical Journal 2024, 6:100756

4. Chin-Chuan Chang, Chih-Hung Chen, Shu-Yuan Hsu, Steve Leu. Cardiomyocyte-specific overexpression of GPR22 ameliorates cardiac injury in mice with acute myocardial infarction. BMC Cardiovascular Disorders 2024, 24(1):287

5. Kang-Shuo Chang, Syue-Ting Chen, Hsin-Ching Sung, Shu-Yuan Hsu, Wei-Yin Lin, Chen-Pang Hou, Yu-Hsiang Lin, Tsui-Hsia Feng, Ke-Hung Tsui, Horng-Heng Juang. Androgen Receptor Upregulates Mucosa-Associated Lymphoid Tissue 1 to Induce NF-κB Activity via Androgen-Dependent and-Independent Pathways in Prostate Carcinoma Cells. International journal of molecular sciences 2023, 24(7):6245

6. Chen-Pang Hou, Ke-Hung Tsui, Kang-Shuo Chang, Hsin-Ching Sung, Shu-Yuan Hsu, Yu-Hsiang Lin, Pei-Shan Yang, Chien-Lun Chen, Tsui-Hsia Feng, Horng-Heng Juang. Caffeic acid phenethyl ester inhibits the growth of bladder carcinoma cells by upregulating growth differentiation factor 15. Biomedical journal 2022, 45(5):763

7. Hsin-Ching Sung, Kang-Shuo Chang, Syue-Ting Chen, Shu-Yuan Hsu, Yu-Hsiang Lin, Chen-Pang Hou, Tsui-Hsia Feng, Ke-Hung Tsui *, Horng-Heng Juang. Metallothionein 2A with Characteristics of Antioxidant and Antitumor is Upregulated by Caffeic Acid Phenethyl Ester in Human Bladder Carcinoma Cells. Antioxidants, 2022, 11, 1509

8. Kang-Shuo Chang, Ke-Hung Tsui, Shu-Yuan Hsu, Hsin-Ching Sung, Yu-Hsiang Lin, Chen-Pang Hou, Pei-Shan Yang, Chien-Lun Chen, Tsui-Hsia Feng, Horng-Heng Juang. The Antitumor Effect of Caffeic Acid Phenethyl Ester by Downregulating Mucosa-Associated Lymphoid Tissue 1 via AR/p53/NF-κB Signaling in Prostate Carcinoma Cells. Cancers, 2022, 14, 274

9. Chen-Pang Hou, Ke-Hung Tsui, Syue-Ting Chen, Kang-Shuo Chang, Hsin-Ching Sung, Shu-Yuan Hsu, Yu-Hsiang Lin, Tsui-Hsia Feng, Horng-Heng Juang. The Upregulation of Caffeic Acid Phenethyl Ester on Growth Differentiation Factor 15 Inhibits Transforming Growth Factor β/Smad Signaling in Bladder Carcinoma Cells. Biomedicines, 2022, 10, 1625

10. Shu-Yuan Hsu, Chih-Hung Chen, Sujira Mukda, Steve Leu. Neuronal Pnn Deficiency Increases Oxidative Stress and Exacerbates Cerebral Ischemia/Reperfusion Injury in Mice. Antioxidants, 2022, 11, 466

11. Chen-Pang Hou, Ke-Hung Tsui, Kang-Shuo Chang, Hsin-Ching Sung, Shu-Yuan Hsu, Yu-Hsiang Lin, Pei-Shan Yang, Chien-Lun Chen, Tsui-Hsia Feng, Horng-Heng Juang. Caffeic acid phenethyl ester inhibits the growth of bladder carcinoma cells by upregulating growth differentiation factor 15. Biomedical Journal, 2021, October 15

12. Sheng-Jia Lin, Yin-Cheng Huang, Hao-Yuan Chen, Jia-You Fang, Shu-Yuan Hsu, Hung-Yu Shih, Yu-Chien Liu, Yi-Chuan Cheng. RGS2 Suppresses Melanoma Growth via Inhibiting MAPK and AKT Signaling Pathways. Anticancer Research, 2021, 41, 6135-6145

13. Ke-Hung Tsui, Kang-Shuo Chang, Hsin-Ching Sung, Shu-Yuan Hsu, Yu-Hsiang Lin, Chen-Pang Hou, Pei-Shan Yang, Chien-Lun Chen, Tsui-Hsia Feng, Horng-Heng Juang. Mucosa-Associated Lymphoid Tissue 1 Is an Oncogene Inducing Cell Proliferation, Invasion, and Tumor Growth via the Upregulation of NF-κB Activity in Human Prostate Carcinoma Cells. Biomedicines, 2021, 9, 250-265

14. SY Hsu, S Mukda, S Leu. Expression and Distribution Pattern of Pnn in Ischemic Cerebral Cortex and Cultured Neural Cells Exposed to Oxygen-Glucose Deprivation. Brain Sciences, 2020, 10 (10), 708

15. KC Chiang, KS Chang, SY Hsu, HC Sung, TH Feng, M Chao, HH Juang. Human Heme Oxygenase-1 Induced by Interleukin-6 via JAK/STAT3 Pathways Is a Tumor Suppressor Gene in Hepatoma Cells. Antioxidants, 2020, 9 (3), 251

16. Chen, C.-H.*; Hsu, S.-Y.*; Chiu, C.-C.; Leu, S. MicroRNA-21 Mediates the Protective Effect of Cardiomyocyte-Derived Conditioned Medium on Ameliorating Myocardial Infarction in Rats. Cells 2019, 8, 935

17. S Leu, SY Hsu, P Ouyang. 4260 Loss of Pnn in cardiomyocytes results in impairment of intercalated discs and arrhythmogenic cardiomyopathy in mice. European Heart Journal, 2019, 40 (Supplement_1), ehz745. 0138