91猫先生

经歷

学歷

研究方向

1. 已建立 F4/80 基因剔除（knock-out）小鼠，以在體內鑑定該分子的生物學功能。
2. 目前積極參與黏附型 GPCR 家族新成員的辨識，以及對這些受體功能的闡明，包括其特異性表達模式與細胞配體的鑑定等。
3. 另一個研究方向是黏附型 GPCR 受體的轉譯後修飾，這涉及一種保守的蛋白水解切割過程及其功能角色。

研究论文(近五年)

1.       Kuan-Yu I^&, Wen-Yi Tseng^&, Wen-Chih Wang, Siamon Gordon, Kwai-Fong Ng and Hsi-Hsien Lin* 2021 Stimulation of vibratory urticaria-associated adhesion-GPCR, EMR2/ADGRE2, triggers the NLRP3 inflammasome activation signal in human monocytes. Frontiers in Immunology 11: 602016 (doi: 10.3389/fimmu.2020.602016) (SCI, IF=5.9) (corresponding author)

2.       Yi-Shu Huang, Wen-Yi Tseng, Joy Ogbechi, Louise M. Topping, Felix Clanchy, Kay McNamee, Dany Perocheau, Nien-Yi Chiang, Peter Ericsson, Anette Sundstedt, Zhongtian Xue, Leif G. Salford, Hans-Olov Sj?gren, Trevor W. Stone, Hsi-Hsien Lin, Shue-Fen Luo^* and Richard O. Williams^* 2021 Pharmacological modulation of T cell immunity results in long-term remission of autoimmune arthritis. Proc Natl Acad Sci USA May 11, 118 (19) e2100939118; (doi:10.1073/pnas2100939118) (SCI, IF=9.1)

3.       Abhishek Kumar Singh and Hsi-Hsien Lin* 2021 The role of GPR56/ADGRG1 in health and disease. Biomedical Journal 44(5):534-547 (doi:10.1016/j.bj.2021.04.012) (SCI, IF=4.4) (Invited Review article, corresponding author)

4.       Kwai-Fong Ng^&, Tse-Ching Chen^&, Martin Stacey, and Hsi-Hsien Lin* 2021 Role of ADGRG1/GPR56 in tumor progression. Cells 10, 3352 (doi.org/10.3390/cells10123352) (SCI, IF=5.2) (Invited Review article, corresponding author).

5.       Hsi-Hsien Lin*, Kwai-Fong Ng, Tse-Ching Chen, Wen-Yi Tseng* 2022 Ligands and Beyond: Mechanosensitive Adhesion GPCRs. Pharmaceuticals 15(2), 219 (doi.org/10.3390/ph15020219) (SCI, IF=4.8) (Invited Review article, co-corresponding author).

6.       Tai-Ying Chu^&, Celine Zheng-Gerard^&, Kuan-Yeh Huang, Yu-Chi Chang, Ying-Wen Chen, Kuan-Yu I, Yu-Ling Lo, Nien-Yi Chiang, Chien-Hao Huang, Hsin-Yi Chen, Martin Stacey, Siamon Gordon, Wen-Yi Tseng, Chiao-Yin Sun, Yen-Mu Wu, Yi-Shin Pan, Chien-Hao Huang, Chun-Yen Lin, Tse-Ching Chen, Kamel El Omari, Marilina Antonelou, Scott R Henderson, Alan Salama, Elena Seiradake*, and Hsi-Hsien Lin* 2022 GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation. Nature Communications 13(1):6385 (doi.org/10.1038/s41467-022-34083-1) (SCI, IF=15.7) (co-corresponding author)

7.       Cheng-Yen Kuo, Meng-Han Tsai, Hsi-Hsien Lin, Yu?Chi Wang, Abhishek Kumar Singh, Chang-Chih Chen, Jainn-Jim Lin, Po-Cheng Hung, Kuang-Lin Lin* 2023 Identification and Clinical Characteristics of a Novel Missense ADGRG1 Variant in Bilateral Frontoparietal Polymicrogyria: the Electroclinical Change from Infancy to Adulthood after Callosotomy in Three Siblings. Epilepsia Open 8:154–164 (doi.org/ 10.1002/epi4.12685) (SCI, IF=2.9)

8.       Scott R Henderson, Harry Horsley, Paul Frankel, Maryam Khosravi, Marilina Antonelou, Rhys DR Evans, Xiang Zhang, Tai-Ying Chu, Hsi-Hsien Lin, Siamon Gordon, Alan D Salama 2023 Proteinase 3 promotes formation of multinucleate giant cells and granuloma-like structures in patients with granulomatosis with polyangiitis. Annals of the Rheumatic Diseases 82(6):848-856. (doi:10.1136/annrheumdis-2021-221800) (SCI, IF= 20.6)

9.       Wen-Yi Tseng, Martin Stacey, Hsi-Hsien Lin* 2023 Role of adhesion G protein-coupled receptors in immune dysfunction and disorder. International Journal of Molecular Sciences 24, 5499 doi:10.3390/ijms24065499 (SCI, IF=4.9) (Invited Review article, corresponding author)

10.   Hsi-Hsien Lin* 2023 Functional Partnerships between GPI-anchored Proteins and Adhesion GPCRs. BioEssays 2023: e2300115. doi:10.1002/bies.202300115 (SCI, IF=2.7) (Invited Review article, corresponding author)

11.   Hsi-Hsien Lin* 2025 An alternative mode of GPCR transactivation: activation of GPCRs by adhesion GPCRs. International Journal of Molecular Sciences 26, 552. doi:10.3390/ijms26020552 (SCI, IF=4.9) (Invited Review article, corresponding author)

12.   Chi-sheng Wu, Hsin-Pai Li, Chia-Hsun Hsieh, Yu-Tsun Lin, Ian Yi-Feng Chang, AnKo Chung, Yenlin Huang, Shir-Hwa Ueng, Yung-Chin Hsiao, Kun-Yi Chien, Ji-Dung Luo, Chia-Hua Chen, Wei-Chao Liao, Jui-lung Hung, Sheng-Ning Yuan, Chun‐Nan OuYang, Wei-Fan Chiang, Chih-Yen Chien, Hui-Ching Chuang, Lichieh Julie Chu, Hsuan Liu, Chia-Yu Yang, Ana I. Robles, Henry Rodriguez, Hsi-Hsien Lin, Huang Yu Yang, Chuen Hsueh, Kai-Ping Chang, Jau-Song Yu, and Yu-Sun Chang 2025 Integrated multi-omics analyses of oral squamous cell carcinoma reveal precision patient stratification and personalized treatment strategies. Cancer Letters 614:217482. doi:10.1016/j.canlet.2025.217482 (SCI, IF=10.1)

13.   Tse-Ching Chen, Kwai-Fong Ng, Ning Chen, Yi-Ling Pan, Chun-An Cheng, Hsiao-Chun Wu, Yi-Jen Hsueh, Nien-Yi Chiang, and Hsi-Hsien Lin* 2025 Evaluation of the immunological functions of placental alkaline phosphatase (ALPP) in vivo using ALPP transgenic mice. Frontiers in Immunology 16:1499388. doi:10.3389/fimmu.2025.1499388 (SCI, IF=5.9) (corresponding author)

14.   Wen-Yi Tseng, Hong-Yi Chen, Yun-Chen Tsai, Yi-Sheng Chan, Chen-I Hsieh, Shih-Che Hung, Yun-Ju Huang, Chang-Fu Kuo, Kuang-Hui Yu, Shue-Fen Luo, Ling-Shan Yu, Hsi-Hsien Lin, Yi-Shu Huang, Richard Williams, and Yeong-Jian Jan Wu 2025 Feasibility Assessment of Radiolabeled FAPI-04 for Diagnostic and Therapeutic Use in Rheumatoid Arthritis. Biomedicine & Pharmacotherapy 187:118048. doi:10.1016/j.biopha.2025.118048 (SCI, IF=7.5)

15.   Kuan-Yeh Huang^&, Kwai-Fong Ng^&, Kuan-Yu I^&, Yu-Chi Chang, Hsin-Yi Chen, Ya-Fang Chiu, Chuan-Mao Hung, Wan-Chen Yu, Tse-Ching Chen, Martin Stacey, and Hsi-Hsien Lin* 2025 GPR56/ADGRG1 induces biased Rho-ROCK-MLC and JAK-STAT3 signaling to promote amoeboid-like morphology and IL-6 upregulation in melanoma cells. Cell Communication and Signaling 23:251. doi:10.1186/s12964-025-02267-z (SCI, IF=8.9) (corresponding author)

16.   Siamon Gordon, Annabell Roberti, Simon Yona, and Hsi-Hsien Lin 2025 F4/80, the plasma membrane antigen of mouse macrophages, an historic journey. Journal of Leukocyte Biology 117(9):qiaf126. doi:10.1093/jleuko/qiaf126 (SCI, IF=3.6) (Invited review article)

17.   Celine Zheng-Gerard*, Jana Joha*, Maria Carrasquero, Kamel el Omari, Ed Lowe, Shirish Dubey, Simon J. Draper, Yu-Chi Chang, Hsi-Hsien Lin**, Alan Salama**, Kirsty McHugh**, Elena Seiradake** 2026 Structures of proteinase 3 and the CD177 receptor complex reveal major autoantibody epitope. EMBO Reports 27(6):1580-1606. doi:10.1038/s44319-026-00716-5 (SCI, IF=6.2)(**co-corresponding authors)

18.   Tobias Langenhan*, ---, Hsi-Hsien Lin, ---, Nicole Scholz* 2026 Adhesion G protein-coupled receptors. Pharmacological Reviews 78:100116. doi:10.1016/j.pharmr.2026.100116 (SCI, IF=17.3)(Invited review article)

19.   Hsi-Hsien Lin, Kirtana Sivasubramanian, Annabell Roberti and Siamon Gordon 2026 The Mononuclear Phagocyte System: A Dispersed Organ. Biomedical Journal (SCI, IF=4.4) (submitted)

20.   Tai-Ying Chu, Kuan-Yu I, Ying-Wen Chen, Yu-Chi Chang, Martin Stacey, Elena Seiradake, Maike Bublitz-Meier and Hsi-Hsien Lin* 2026 GPR97-mediated Allosteric Activation of mPR3 Induces PAR2 Activation in Neutrophils by Unveiling Novel Tethered Agonist Peptides. (submitted)(corresponding author)

21.   Ying-Wen Chen, Jaw-Lin Wang, and Hsi-Hsien Lin* 2026 Low-intensity ultrasound induces mechano-dissociation of ADGRE2/EMR2: Evidence for Adhesion GPCRs as ultrasound-responsive receptors. Biomedical Journal (SCI, IF=4.4)(in preparation)