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长庚大学
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賴志河教授_照片

賴志河 教授 / Chih-Ho Lai Ph.D.

职称： 教授

现职： 长庚大学微生物及免疫學科

信箱： chlai@mail.cgu.edu.tw

电话： 03-2118800 #5116

学歷： 國立清華大學 博士

专长领域： 感染免疫

经歷

2016  長庚紀念醫院分子感染症醫學研究中心 研究員
2015  长庚大学微生物與免疫學系 教授
2015  长庚大学生物醫學研究所 教授
2013  中國醫藥大學微生物與免疫學系 教授
2011  德州大學西南分校泌尿外科 助理教授
2006  中國醫藥大學微生物及免疫學科 助理教授
2005  日本新潟大學傳染病控制與國際醫學研究所 博士後研究員

学歷

2005  國立清華大學 生命科學系 博士
1996  國防醫學院 微生物與免疫學研究所 碩士
1994  中國醫藥大學 醫療科技系 學士

研究方向

微生物致病机转与宿主免疫反应
开发细菌毒素应用於治疗癌干细胞
微生物相(尘颈肠谤辞产颈辞迟补)与转译医学


Laboratory of Infection and Immunity

研究论文(选录)

  • Lai CH*, Wu SY, Li SW, Ho QNU, Chiang RL, Bui NN, Wu HY. Huang YT, Chiu CH, Wang WC. Region-specific genomic variation and functional divergence of Helicobacter pylori clinical isolates from the gastric antrum and corpus. mSystems. 2025: doi: 10.1128/msystems.01029-25 (IF=4.6)
  • Chang KW, Chen JT, Chuang CN, Thao DTT, Huang YT, Wu HY, Kuo ML, Kao KC, Chiu CH, Lai CH*. Microplastic exposure aggravates pneumococcus-induced inflammation in macrophages by activating ferroptosis. Journal of Hazardous Materials. 2025: doi:10.1016/j.jhazmat.2025.139696 (IF=11.3)
  • Lien HM, Wang YY, Li SW, Lin HJ, Wu HY, Huang YT, Chen CY, Chen CC, Chiu CH, Lai CH* Anisomeles indica enriched with ovatodiolide protects against aspirin-induced gastric ulcers through gut microbiota modulation. Biomedical Journal. 2025:100893. doi: 10.1016/j.bj.2025.100893 (IF=4.5)
  • Que AT, Tran AD, Trang THN, Tran TNL, Bui NN, Lai CH*. Epidemiology and antimicrobial resistance patterns of urinary tract infection: insights and strategies from a 5-year serial cross-sectional study in Vietnam. Ther Adv Infect Dis. 2025;12. doi: 10.1177/20499361251315346 (IF=3.4)
  • Bui NN, Huang SC, Le Tran TN, Nguyen NH, Do HN, Chiu YF, Lai CH*. Association between Helicobacter pylori and Epstein-Barr virus co-infection and gastric cancer risk: A systematic review and meta-analysis. QJM An International Journal of Medicine. 2025:hcaf092. doi: 10.1093/qjmed/hcaf092 (IF=6.5)
  • Yeh JA, Huang HK, Chou AL, Lin HJ, Feng CL, Kuo CJ, Lai CH*. Helicobacter pylori eradication with high-dose proton pump inhibitor-amoxicillin dual therapy: A systematic review and meta-analysis. Int J Antimicrob Agents. 2024;63(6):107159.
  • Ma J?, Chiu YF?, Kao CC, Chuang CN, Chen CY, Lai CH?, Kuo ML*. Fine particulate matter manipulates immune response to exacerbate microbial pathogenesis in the respiratory tract. Eur Respir Rev. 2024 Sep 4;33(173):230259. (?equal contribution)
  • Chang YF, Huang YP, Chou CH, Ho MW, Lin HJ, Chen CY, Wu HY, Lai YR, Lee YH, Chiu CH, Lai CH*. RAGE participates in the intracellular transport of Campylobacter jejuni cytolethal distending toxin. J Microbiol Immunol Infect. 2024:S1684-1182(24)00118-X. 
  • Ho SM?, Tsai WH?, Lai CH?, Chiang MH, Lee WP, Wu HY, Bai PY, Wu T, Wu CL*. Probiotic Lactobacillus spp. improves Drosophila memory by increasing lactate dehydrogenase levels in the brain mushroom body neurons. Gut Microbes. 2024;16(1):2316533. (?equal contribution)
  • Huang HL, Lai CH, Tsai WH, Chen KW, Peng SL, Lin JH, Lin YH. Nanoparticle-enhanced postbiotics: Revolutionizing cancer therapy through effective delivery. Life Sci. 2024;337:122379.
  • Kuo CJ, Bui NN, Ke JN, Lin CY, Lin WR, Chang ML, Wu HY, Huang MZ, Chiu CH, Chiu CT, Lai CH*. Molecular characterization of rifabutin-resistance in refractory Helicobacter pylori infection in Taiwan. Int J Infect Dis. 2023;138:25-28. 
  • Wu HY, Kuo CJ, Chou CH, Ho MW, Chen CL, Hsu TS, Chen YC, Chiang-Ni C, Chen YM, Chiu CH, Lai CH*. Clostridium innocuum, an emerging pathogen that induces lipid raft-mediated cytotoxicity. Virulence. 2023;14(1):2265048.
  • Bui NN, Li CY, Wang LY, Chen YA, Kao WH, Chou LF, Hsieh JT, Lin H, Lai CH*. Clostridium scindens metabolites trigger prostate cancer progression through androgen receptor signaling. J Microbiol Immunol Infect. 2023;56(2):246-256.
  • Kuo CJ, Ke JN, Kuo T, Lin CY, Hsieh SY, Chiu YF, Wu HY, Huang MZ, Bui NN, Chiu CH, Chiu CT, Lai CH*. Multiple amino acid substitutions in penicillin-binding protein-1A confer amoxicillin resistance in refractory Helicobacter pylori infection. J Microbiol Immunol Infect. 2023;56(1):40-47.
  • Lai CH*, Lin TL, Huang MZ, Li SW, Wu HY, Chiu YF, Yang CY, Chiu CH, Lai HC*. Gut commensal P. goldsteinii MTS01 alters gut microbiota composition and reduces cholesterol to mitigate Helicobacter pylori-induced pathogenesis. Front Immunol. 2022;13 (916848):1-13.
  • Chou LF, Chen TW, Yang HY, Tian YC, Chang MY, Hung CC, Lai CH, Hsu SH, Tsai CY, Ko YC, Lian JH, Yang CW. Implication of the IL-10-expression signature in the pathogenicity of Leptospira-infected macrophages. Microbiol Spectr. 2022;10(3):e0259521.
  • Lo UG, Chen YA, Cen J, Deng S, Luo J, Zhau H, Ho L, Lai CH, Mu P, Chung LWK, Hsieh JT*. The driver role of JAK-STAT signaling in cancer stemness capabilities leading to new therapeutic strategies for therapy- and castration-resistant prostate cancer. Clin Transl Med. 2022;12(8):e978.
  • Chiang MH, Ho SM, Wu HY, Lin YC, Tsai WH, Wu T, Lai CH*, Wu CL*. Drosophila model for studying gut microbiota in behaviors and neurodegenerative diseases. Biomedicines. 2022;10(3):596.
  • Lee CF, Chen YA, Hernandez E, Pong RC, Ma S, Hofstad M, Kapur P, Zhau H, Chung LW, Lai CH, Lin H, Lee MS, Raj GV, Hsieh JT*. The central role of Sphingosine kinase 1 in the development of neuroendocrine prostate cancer (NEPC): A new targeted therapy of NEPC. Clin Transl Med. 2022;12(2):e695.
  • Hsu CY, Yeh JY, Chen CY, Wu HY, Chiang MH, Wu CL, Lin HJ, Chiu CH, Lai CH*. Helicobacter pylori cholesterol-α-glucosyltransferase manipulates cholesterol for bacterial adherence to gastric epithelial cells. Virulence. 2021;12(1): 2341-2351.