91猫先生

移到主要内容

长庚大学
:::
郭敏玲教授_照片

郭敏玲 特聘教授 / Ming-Ling Kuo Ph.D.

职称： 所长/特聘教授

现职： 长庚大学生物醫學研究所 / 长庚大学分子及臨床免疫中心助理研究員

信箱： mingling@mail.cgu.edu.tw

电话： 03-2118800 #3319 or 3320

学歷： 美國羅格斯大學 博士

专长领域： 过敏免疫、气喘药物开发、免疫调节

个人网页： https://pure.lib.cgu.edu.tw/zh/persons/jhan-jie-peng/

经歷

2024-         长庚大学特聘教授
2022-         长庚大学生物醫學研究所 所長
2021-         Biomedical Journal期刊 主編
2013-         中華民國免疫學會 理事
2010-         长庚大学微生物及免疫學科 教授
2010-         衛生福利部食品藥物管理屬健康食品審議委員會產品審查委員
2009-         經濟部SBIR評審委員
2016-2019  长庚大学研究發展處 處長
2009-2016  长庚大学微生物及免疫學科主任
2015-2016  长庚大学教務處研教組組長
2017-2024  國家發展委員會投資審議委員會委員
2006-2013  衛生福利部食品藥物管理署健康食品審議委員會基因改造食品審查委員
2002-2010  长庚大学微生物及免疫學科/生物醫學研究所 副教授
2000-2003  長庚兒童醫院健康研究ˋ部技術主任
1996-2002  長庚紀念醫院醫學研究中心助理研究員
1994-1996  國立臺灣大學醫院肝炎研究中心博士後研究員

学歷

1994  美國羅格斯大學 微生物學與分子遺傳學 博士
1988  美國俄亥俄州立大學 微生物及免疫學研究所 碩士
1985  國立台灣大學 農業化學系 學士

研究方向

人类间质干细胞的免疫调节功能
开发治疗哮喘的新药
腺相关病毒介导的基因转移以减弱哮喘反应


Laboratory of Molecular Immunology

研究论文(选录近五年)

1.        Chang K-W, Chen J-T, Chiang-Ni C, Dang Thi Thanh Thao, Huang Y-T, Wu H-Y, Kuo M-L, Kao K-C, Chiu C-H, Lai C-H. Microplastic exposure aggravates pneumococcus-induced inflammation in macrophages by activating ferroptosis. J. Hazard Mater. 2025; 497: 139696. (DOI: 10.1016/j.jhazmat.2025.139696)

2.        Ma J, Yang T-H, Hsiung C-C, Sun H-Y, Kuo M-L*. Isolate circulating mesenchymal stromal cells using a gradient-free and growth factor-free method. Stem Cells Int. 2025; 5545892. (DOI: 10.1155/sci/5545892)

3.        Chen J-C, Hsu M-H, Kuo R-L, Wang L-T, Kuo M-L, Tseng L- Y, Chang H-L, Chiu C-H. mRNA-1273 is placenta-permeable and immunogenic in the fetus. Mol. Ther. Nucl. Acids. 2025; 36: 102489. (DOI: 10.1016/j.omtn.2025.102489)

4.        Kuo C-Y, Huang C-Y, Chen H-M, Chen L-C, Kuo M-L*. Antagonism of CD28 blocks allergic responses in the ovalbumin-induced asthmatic model mice. Int. Immunopharmacol. 2025; 148: 114071. (DOI:10.1016/j.intimp.2025.114071)

5.        Ma J, Chiu Y-F, Kao C-C, Chun-Ning C, Chen C-Y, Lai C-H, Kuo M-L*. Fine particulate matter manipulates immune response to exacerbate microbial pathogenesis in the respiratory tract. Eur. Respir. Rev. 2024; 33: 230259. (DOI: 10.1183/16000617.0259-2023)

6.        Chang-Chien J, Huang J-L, Tsai H-J, Wang S-L, Kuo M-L?, Yao T-C?.Vitamin D ameliorates particulate matter induced mitochondrial damages and calcium dyshomeostasis in BEAS-2B human bronchial epithelial cells. Respir. Res. 2024; 25: 321-335. (DOI: 10.1186/s12931-024-02951-7)

7.        Chang-Chien J, Kuo M-L, Tseng Y-L, Huang H-Y, Tsai H-J, Yao T-C. Differential effects of long- and short-term exposure to PM2.5 on accelerating telomere shortening: from in vitro to epidemiological studies. Ecotox. Environ. Safe. 2024; 281: 116650. (DOI: 10.1016/j.ecoenv.2024.116650. Epub 2024 Jul 3.)

8.        Chen J-C*, Ou L-S, Kuo M-L, Tseng L-Y, Chang H-L. Autoantigen exposure in murine fetuses elicited nonpathogenic autoimmunity. Arch. Med. Res. 2024; 55: 103013. (DOI: 10.1016/j.arcmed.2024.103013)

9.        Huang Y-A, Chen J-C Chiang P-C, Chen L-C, Kuo M-L*. Adeno-associated viral vector-delivered pannexin-1 mimetic peptide alleviates airway inflammation in an allergen-sensitized mouse model. Hum. Gene Ther. 2023; 33: 1107-1117. (DOI: 10.1089/hum.2023.078)

10.    Chiang P-C, Chen J-C, Chen L-C, Kuo M-L*. Adeno-associated virus-mediated interleukin-12 gene expression alleviates lung inflammation and type 2 T-helper-responses in ovalbumin-sensitized asthmatic mice. Hum. Gene Ther. 2022; 33: 1052-1061. (DOI: 10.1089/hum.2022.034)

11.    Ting N-C, Chen Y-H, Chen J-C, Huang W-C, Liou C-J, Chen L-C, Yang S-H?, Kuo M-L?. Perilla fruit water extract attenuates inflammatory responses and alleviates neutrophil recruitment via MAPK/JNK-AP-1/c-Fos signaling pathway in ARDS animal model. Evid. Based Complement. Alternat. Med. 2022; 2022: 4444513. (DOI: 10.1155/2022/4444513)

12.    Lai Y-R, Chang Y-F, Ma J, Chiu C-H, Kuo M-L?, Lai C-H?. From DNA damage to cancer progression: potential effects of cytolethal distending toxin. Front. Immunol. 2021; 2021: 12 (DOI: 10.3389/fimmu.2021.760451)

13.    Hsu L-J, Liu C-L, Kuo M-L, Shen C-N, Shen C-R. An alternative cell therapy for cancers: Induced pluripotent stem cell (iPSC)-derived natural killer cells. Biomedicines. 2021; 9: 1323-1339. (DOI: 10.3390/biomedicines9101323)

14.    Chen L-C, Tseng H-M, Kuo M-L, Chiu C-Y, Liao S-L, Su K-W, Tsai M-H, Hua M-C, Lai S-H, Yao T-S, Yeh K-W, Wu A-H, Yu H-Y, Huang J-L, Huang S-K. Levels of 15-HETE and TXB in exhaled breadth condensates as markers for diagnosis of childhood asthma and its therapeutic outcome. Pediatr. Allergy Immunol. 2021; 32: 1673-1680 (DOI: 10.1111/pai.13587)

15.    Ma J, Liu M-X, Chen L-C, Shen J-J, Kuo M-L*. Ding Chuan Tang attenuates airway inflammation and eosinophil infiltration in ovalbumin-sensitized asthmatic mice. Biomed. Res. Int. 2021; 2021: 6692772, 10 pages. (DOI: 10.1155/2021/6692772)

16.    Chang-Chien J, Huang J-L, Tsai H-J, Wang S-L, Kuo M-L?, Yao T-C?. Particulate matter causes telomere shortening and cellular senescence in human lung epithelial cells. Ecotox. Environ. Safe. 2021. 222: 112484-112492. (DOI: 10.1016/j.ecoenv.2021.112484)

17.    Chen J-C, Chan C-C, Ting N-C, Kuo M-L*. Allergen exposure in murine neonates promoted the development of allergic lungs. Biomedicines. 2021; 9: 688-703. (DOI: 10.3390/biomedicines9060688)

18.    Huang Y-A, Chen J-C, Wu C-C, Hsu C-W, Ko Albert M-S, Chen L-C, Kuo M-L*. Reducing lung ATP levels and alleviating asthmatic airway inflammation through adeno-associated viral vector-mediated CD39 expression. Biomedicines. 2021; 9: 656-669. (DOI: 10.3390/biomedicines9060656)

19.    Chen J-C, Ou L-S, Kuo M-L, Tseng L-Y, Chang H-L, Chen S-C, Chui C-H. Fetal macrophages exposed to Salmonella antigens elicit protective immunity against overwhelming Salmonella challenge in a murine model. Biomedicines. 2021; 9: 245-260. (DOI: 10.3390/biomedicines9030245)