91猫先生

Employment Records

2022.08- present       Director, Graduate Institute of Biomedical Sciences, 91猫先生

2024.02- present     Distinguished Professor, Chang Gung University

2010.08- present     Professor, Department of Microbiology and Immunology/Graduate Institute of Biomedical Sciences, 91猫先生

2021.11-present        Co-Editor-in-Chief, Biomedical Journal

2013.10-present        General Council Member, Chinese Society of Immunology

2010-present             Product Review Committee, Health Food Committee, Taiwan Food and Drug Administration, Ministry of Health and Welfare

2009-present             SBIR (Small Business Innovation Research) Evaluation Committee, Ministry of Economic Affairs

2016.08-2019.07     Dean of Research and Development, 91猫先生

2009.08-2016.07      Chairman, Department of Microbiology and Immunology, 91猫先生

2015.08-2016.07      Section Head, Graduate Studies Section, Office of Academic Affairs, 91猫先生

2017.01-2024.12      Investment Review Committee, National Development Council

2006.01-2013.12      Genetic Modified Food Review Committee, Health Food Committee, Taiwan Food and Drug Administration, Ministry of Health and Welfare

2002.08-2010.07      Associate Professor, Department of Microbiology and Immunology/ Graduate Institute of Biomedical Sciences, Chang Gung University

2000.09-2003.07      Director of Techniques, Health Research Division, Chang Gung Children’s Hospital

1996.10-2002.07      Associate Research Fellow, Medical Research Center, Chang Gung Memorial Hospital

1994.09-1996.09      Postdoctoral fellow, Hepatitis Research Center, National Taiwan University Hospital

Education

Research Interests

Publications

1.        Chang K-W, Chen J-T, Chiang-Ni C, Dang Thi Thanh Thao, Huang Y-T, Wu H-Y, Kuo M-L, Kao K-C, Chiu C-H, Lai C-H. Microplastic exposure aggravates pneumococcus-induced inflammation in macrophages by activating ferroptosis. J. Hazard Mater. 2025; 497: 139696. (DOI: 10.1016/j.jhazmat.2025.139696)

2.        Ma J, Yang T-H, Hsiung C-C, Sun H-Y, Kuo M-L^*. Isolate circulating mesenchymal stromal cells using a gradient-free and growth factor-free method. Stem Cells Int. 2025; 5545892. (DOI: 10.1155/sci/5545892)

3.        Chen J-C, Hsu M-H, Kuo R-L, Wang L-T, Kuo M-L, Tseng L- Y, Chang H-L, Chiu C-H. mRNA-1273 is placenta-permeable and immunogenic in the fetus. Mol. Ther. Nucl. Acids. 2025; 36: 102489. (DOI: 10.1016/j.omtn.2025.102489)

4.        Kuo C-Y, Huang C-Y, Chen H-M, Chen L-C, Kuo M-L^*. Antagonism of CD28 blocks allergic responses in the ovalbumin-induced asthmatic model mice. Int. Immunopharmacol. 2025; 148: 114071. (DOI:10.1016/j.intimp.2025.114071)

5.        Ma J, Chiu Y-F, Kao C-C, Chun-Ning C, Chen C-Y, Lai C-H, Kuo M-L^*. Fine particulate matter manipulates immune response to exacerbate microbial pathogenesis in the respiratory tract. Eur. Respir. Rev. 2024; 33: 230259. (DOI: 10.1183/16000617.0259-2023)

6.        Chang-Chien J, Huang J-L, Tsai H-J, Wang S-L, Kuo M-L^?, Yao T-C^?.Vitamin D ameliorates particulate matter induced mitochondrial damages and calcium dyshomeostasis in BEAS-2B human bronchial epithelial cells. Respir. Res. 2024; 25: 321-335. (DOI: 10.1186/s12931-024-02951-7)

7.        Chang-Chien J, Kuo M-L, Tseng Y-L, Huang H-Y, Tsai H-J, Yao T-C. Differential effects of long- and short-term exposure to PM2.5 on accelerating telomere shortening: from in vitro to epidemiological studies. Ecotox. Environ. Safe. 2024; 281: 116650. (DOI: 10.1016/j.ecoenv.2024.116650. Epub 2024 Jul 3.)

8.        Chen J-C*, Ou L-S, Kuo M-L, Tseng L-Y, Chang H-L. Autoantigen exposure in murine fetuses elicited nonpathogenic autoimmunity. Arch. Med. Res. 2024; 55: 103013. (DOI: 10.1016/j.arcmed.2024.103013)

9.        Huang Y-A, Chen J-C Chiang P-C, Chen L-C, Kuo M-L^*. Adeno-associated viral vector-delivered pannexin-1 mimetic peptide alleviates airway inflammation in an allergen-sensitized mouse model. Hum. Gene Ther. 2023; 33: 1107-1117. (DOI: 10.1089/hum.2023.078)

10.    Chiang P-C, Chen J-C, Chen L-C, Kuo M-L^*. Adeno-associated virus-mediated interleukin-12 gene expression alleviates lung inflammation and type 2 T-helper-responses in ovalbumin-sensitized asthmatic mice. Hum. Gene Ther. 2022; 33: 1052-1061. (DOI: 10.1089/hum.2022.034)

11.    Ting N-C, Chen Y-H, Chen J-C, Huang W-C, Liou C-J, Chen L-C, Yang S-H^?, Kuo M-L^?. Perilla fruit water extract attenuates inflammatory responses and alleviates neutrophil recruitment via MAPK/JNK-AP-1/c-Fos signaling pathway in ARDS animal model. Evid. Based Complement. Alternat. Med. 2022; 2022: 4444513. (DOI: 10.1155/2022/4444513)

12.    Lai Y-R, Chang Y-F, Ma J, Chiu C-H, Kuo M-L^?, Lai C-H^?. From DNA damage to cancer progression: potential effects of cytolethal distending toxin. Front. Immunol. 2021; 2021: 12 (DOI: 10.3389/fimmu.2021.760451)

13.    Hsu L-J, Liu C-L, Kuo M-L, Shen C-N, Shen C-R. An alternative cell therapy for cancers: Induced pluripotent stem cell (iPSC)-derived natural killer cells. Biomedicines. 2021; 9: 1323-1339. (DOI: 10.3390/biomedicines9101323)

14.    Chen L-C, Tseng H-M, Kuo M-L, Chiu C-Y, Liao S-L, Su K-W, Tsai M-H, Hua M-C, Lai S-H, Yao T-S, Yeh K-W, Wu A-H, Yu H-Y, Huang J-L, Huang S-K. Levels of 15-HETE and TXB in exhaled breadth condensates as markers for diagnosis of childhood asthma and its therapeutic outcome. Pediatr. Allergy Immunol. 2021; 32: 1673-1680 (DOI: 10.1111/pai.13587)

15.    Ma J, Liu M-X, Chen L-C, Shen J-J, Kuo M-L*. Ding Chuan Tang attenuates airway inflammation and eosinophil infiltration in ovalbumin-sensitized asthmatic mice. Biomed. Res. Int. 2021; 2021: 6692772, 10 pages. (DOI: 10.1155/2021/6692772)

16.    Chang-Chien J, Huang J-L, Tsai H-J, Wang S-L, Kuo M-L^?, Yao T-C^?. Particulate matter causes telomere shortening and cellular senescence in human lung epithelial cells. Ecotox. Environ. Safe. 2021. 222: 112484-112492. (DOI: 10.1016/j.ecoenv.2021.112484)

17.    Chen J-C, Chan C-C, Ting N-C, Kuo M-L^*. Allergen exposure in murine neonates promoted the development of allergic lungs. Biomedicines. 2021; 9: 688-703. (DOI: 10.3390/biomedicines9060688)

18.    Huang Y-A, Chen J-C, Wu C-C, Hsu C-W, Ko Albert M-S, Chen L-C, Kuo M-L^*. Reducing lung ATP levels and alleviating asthmatic airway inflammation through adeno-associated viral vector-mediated CD39 expression. Biomedicines. 2021; 9: 656-669. (DOI: 10.3390/biomedicines9060656)

19.    Chen J-C, Ou L-S, Kuo M-L, Tseng L-Y, Chang H-L, Chen S-C, Chui C-H. Fetal macrophages exposed to Salmonella antigens elicit protective immunity against overwhelming Salmonella challenge in a murine model. Biomedicines. 2021; 9: 245-260. (DOI: 10.3390/biomedicines9030245)