Hsi-Hsien Lin Ph.D.
闯辞产罢颈迟濒别： Professor
颁耻谤谤别苍迟闯辞产： Graduate Institute of Biomedical Sciences, 91猫先生
贰-尘补颈濒： hhlin@mail.cgu.edu.tw
笔丑辞苍别： 03-2118800 #3321
贰诲耻肠补迟颈辞苍： Ph.D., University of Tennessee, USA
贰虫辫别谤迟颈蝉别： Basic Immunology
Employment Records
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08/2023 - present
08/2025 - 01/2026
08/2024 - 01/2025
11/2020 - present
09/2016 - 02/2017 01/2016 - present
08/2013 - 02/2022
08/2011 - present
08/2007 - 07/2011 |
Head, Department of Microbiology and Immunology, College of Medicine, 91猫先生, Taiwan. Visiting Professor, Department of Biochemistry and Kavli Institute for Nanoscience Discovery, University of Oxford, UK Visiting Professor, Department of Biochemistry and Kavli Institute for Nanoscience Discovery, University of Oxford, UK Adjunct Researcher, Division of Rheumatology, Allergy, and Immunology, Chang Gung Memorial Hospital-Keelung, Keelung, Taiwan Visiting Professor, The Kennedy Institute of Rheumatology, University of Oxford, UK Adjunct Researcher, Department of Anatomic Pathology, Chang Gung Memorial Hospital-Linkou, Taoyuan, Taiwan Director, Graduate Program of Molecular Medicine, College of Medicine, 91猫先生, Taiwan. Professor/Laboratory Head, Laboratory of Molecular Immunology, Department of Microbiology and Immunology, College of Medicine, 91猫先生, Taiwan. Associate Professor/Laboratory Head, Laboratory of Molecular Immunology, Department of Microbiology and Immunology, College of Medicine, 91猫先生, Taiwan. |
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12/2004 - 07/2007 |
Assistant Professor/Laboratory Head, Laboratory of Molecular Immunology, Department of Microbiology and Immunology, 91猫先生, Taiwan. |
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07/2000 - 11/2004 |
Group leader/Senior Research Fellow, Sir William Dunn School of Pathology, the University of Oxford, UK. · Functional study of the EGF-TM7 receptors. |
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07/1998 - 07/2000 |
Research Fellow, Sir William Dunn School of Pathology, the University of Oxford, UK. · Functional study of the EGF-TM7 receptors. |
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12/97 - 06/98 |
Postdoctoral Research Scientist, Oak Ridge National Laboratory, TN, U.S.A. · Gene expression profiling using genosensor (DNA chip) technology. |
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08/1992 - 12/1997 |
Graduate Research Assistant, University of Tennessee – Knoxville, TN, U.S.A. · Studied the functions of novel genes identified by differential display in c-myb mutant mice |
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07/1989 - 07/1992 |
Research Assistant, Department of Medical Research, Veterans General Hospital – Taipei, Taiwan. · Molecular cloning and sequence analysis of a common precursor for a putative hemorrhagic protein and rhodostomin. · Studied the effect of snake venom platelet inhibitor (Rhodostomin) on cell attachment. |
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06/1987 - 06/1989 |
Graduate Research Student, Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan. · Growth and characterization of a newly established human pituitary tumor cell line. |
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06/1986 - 06/1987 |
Undergraduate Research Student, Department of Biology, National Cheng Kung University, Tainan, Taiwan. · Studied the mechanism of d-aminolevulinic acid synthetase. |
Education
Ph.D. in Biomedical Sciences, University of Tennessee - Oak Ridge Graduate School of Biomedical Sciences, USA (1997)Master of Science (M.S.) in Biochemistry, College of Medicine, National Taiwan University, Taiwan (1989)
Bachelor of Science (B.S.) in Biology, National Cheng Kung University, Taiwan (1987)
Research Interests
1. I have generated F4/80 knock-out mice to characterize the biological functions of the molecule in vivo.
2. I am actively involved in identification of new members of the adhesion-GPCR family and the elucidation of the functions of these receptors including their specific expression patterns and the identification of their cellular ligands, etc.
3. Another area of interest in the post-translational modification of the adhesion-GPCR receptor, which involves a conserved proteolytic cleavage process and its functional role.
Publications
1. Kuan-Yu I&, Wen-Yi Tseng&, Wen-Chih Wang, Siamon Gordon, Kwai-Fong Ng and Hsi-Hsien Lin* 2021 Stimulation of vibratory urticaria-associated adhesion-GPCR, EMR2/ADGRE2, triggers the NLRP3 inflammasome activation signal in human monocytes. Frontiers in Immunology 11: 602016 (doi: 10.3389/fimmu.2020.602016) (SCI, IF=5.9) (corresponding author)
2. Yi-Shu Huang, Wen-Yi Tseng, Joy Ogbechi, Louise M. Topping, Felix Clanchy, Kay McNamee, Dany Perocheau, Nien-Yi Chiang, Peter Ericsson, Anette Sundstedt, Zhongtian Xue, Leif G. Salford, Hans-Olov Sj?gren, Trevor W. Stone, Hsi-Hsien Lin, Shue-Fen Luo* and Richard O. Williams* 2021 Pharmacological modulation of T cell immunity results in long-term remission of autoimmune arthritis. Proc Natl Acad Sci USA (doi:10.1073/pnas2100939118) (SCI, IF=9.1)
3. Abhishek Kumar Singh and Hsi-Hsien Lin* 2021 The role of GPR56/ADGRG1 in health and disease. Biomedical Journal 44(5):534-547 (doi:10.1016/j.bj.2021.04.012) (SCI, IF=4.4) (Invited Review article, corresponding author)
4. Kwai-Fong Ng&, Tse-Ching Chen&, Martin Stacey, and Hsi-Hsien Lin* 2021 Role of ADGRG1/GPR56 in tumor progression. Cells 10, 3352 (doi.org/10.3390/cells10123352) (SCI, IF=5.2) (Invited Review article, corresponding author).
5. Hsi-Hsien Lin*, Kwai-Fong Ng, Tse-Ching Chen, Wen-Yi Tseng* 2022 Ligands and Beyond: Mechanosensitive Adhesion GPCRs. Pharmaceuticals 15(2), 219 (doi.org/10.3390/ph15020219) (SCI, IF=4.8) (Invited Review article, co-corresponding author).
6. Tai-Ying Chu&, Celine Zheng-Gerard&, Kuan-Yeh Huang, Yu-Chi Chang, Ying-Wen Chen, Kuan-Yu I, Yu-Ling Lo, Nien-Yi Chiang, Chien-Hao Huang, Hsin-Yi Chen, Martin Stacey, Siamon Gordon, Wen-Yi Tseng, Chiao-Yin Sun, Yen-Mu Wu, Yi-Shin Pan, Chien-Hao Huang, Chun-Yen Lin, Tse-Ching Chen, Kamel El Omari, Marilina Antonelou, Scott R Henderson, Alan Salama, Elena Seiradake*, and Hsi-Hsien Lin* 2022 GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation. Nature Communications 13(1):6385 (doi.org/10.1038/s41467-022-34083-1) (SCI, IF=15.7) (co-corresponding author)
7. Cheng-Yen Kuo, Meng-Han Tsai, Hsi-Hsien Lin, Yu?Chi Wang, Abhishek Kumar Singh, Chang-Chih Chen, Jainn-Jim Lin, Po-Cheng Hung, Kuang-Lin Lin* 2023 Identification and Clinical Characteristics of a Novel Missense ADGRG1 Variant in Bilateral Frontoparietal Polymicrogyria: the Electroclinical Change from Infancy to Adulthood after Callosotomy in Three Siblings. Epilepsia Open 8:154–164 (doi.org/ 10.1002/epi4.12685) (SCI, IF=2.9)
8. Scott R Henderson, Harry Horsley, Paul Frankel, Maryam Khosravi, Marilina Antonelou, Rhys DR Evans, Xiang Zhang, Tai-Ying Chu, Hsi-Hsien Lin, Siamon Gordon, Alan D Salama 2023 Proteinase 3 promotes formation of multinucleate giant cells and granuloma-like structures in patients with granulomatosis with polyangiitis. Annals of the Rheumatic Diseases 82(6):848-856. (doi:10.1136/annrheumdis-2021-221800) (SCI, IF= 20.6)
9. Wen-Yi Tseng, Martin Stacey, Hsi-Hsien Lin* 2023 Role of adhesion G protein-coupled receptors in immune dysfunction and disorder. International Journal of Molecular Sciences 24, 5499 doi:10.3390/ijms24065499 (SCI, IF=4.9) (Invited Review article, corresponding author)
10. Hsi-Hsien Lin* 2023 Functional Partnerships between GPI-anchored Proteins and Adhesion GPCRs. BioEssays 2023: e2300115. doi:10.1002/bies.202300115 (SCI, IF=2.7) (Invited Review article, corresponding author)
11. Hsi-Hsien Lin* 2025 An alternative mode of GPCR transactivation: activation of GPCRs by adhesion GPCRs. International Journal of Molecular Sciences 26, 552. doi:10.3390/ijms26020552 (SCI, IF=4.9) (Invited Review article, corresponding author)
12. Chi-sheng Wu, Hsin-Pai Li, Chia-Hsun Hsieh, Yu-Tsun Lin, Ian Yi-Feng Chang, AnKo Chung, Yenlin Huang, Shir-Hwa Ueng, Yung-Chin Hsiao, Kun-Yi Chien, Ji-Dung Luo, Chia-Hua Chen, Wei-Chao Liao, Jui-lung Hung, Sheng-Ning Yuan, Chun‐Nan OuYang, Wei-Fan Chiang, Chih-Yen Chien, Hui-Ching Chuang, Lichieh Julie Chu, Hsuan Liu, Chia-Yu Yang, Ana I. Robles, Henry Rodriguez, Hsi-Hsien Lin, Huang Yu Yang, Chuen Hsueh, Kai-Ping Chang, Jau-Song Yu, and Yu-Sun Chang 2025 Integrated multi-omics analyses of oral squamous cell carcinoma reveal precision patient stratification and personalized treatment strategies. Cancer Letters 614:217482. doi:10.1016/j.canlet.2025.217482 (SCI, IF=10.1)
13. Tse-Ching Chen, Kwai-Fong Ng, Ning Chen, Yi-Ling Pan, Chun-An Cheng, Hsiao-Chun Wu, Yi-Jen Hsueh, Nien-Yi Chiang, and Hsi-Hsien Lin* 2025 Evaluation of the immunological functions of placental alkaline phosphatase (ALPP) in vivo using ALPP transgenic mice. Frontiers in Immunology 16:1499388. doi:10.3389/fimmu.2025.1499388 (SCI, IF=5.9) (corresponding author)
14. Wen-Yi Tseng, Hong-Yi Chen, Yun-Chen Tsai, Yi-Sheng Chan, Chen-I Hsieh, Shih-Che Hung, Yun-Ju Huang, Chang-Fu Kuo, Kuang-Hui Yu, Shue-Fen Luo, Ling-Shan Yu, Hsi-Hsien Lin, Yi-Shu Huang, Richard Williams, and Yeong-Jian Jan Wu 2025 Feasibility Assessment of Radiolabeled FAPI-04 for Diagnostic and Therapeutic Use in Rheumatoid Arthritis. Biomedicine & Pharmacotherapy 187:118048. doi:10.1016/j.biopha.2025.118048 (SCI, IF=7.5)
15. Kuan-Yeh Huang&, Kwai-Fong Ng&, Kuan-Yu I&, Yu-Chi Chang, Hsin-Yi Chen, Ya-Fang Chiu, Chuan-Mao Hung, Wan-Chen Yu, Tse-Ching Chen, Martin Stacey, and Hsi-Hsien Lin* 2025 GPR56/ADGRG1 induces biased Rho-ROCK-MLC and JAK-STAT3 signaling to promote amoeboid-like morphology and IL-6 upregulation in melanoma cells. Cell Communication and Signaling 23:251. doi:10.1186/s12964-025-02267-z (SCI, IF=8.9) (corresponding author)
16. Siamon Gordon, Annabell Roberti, Simon Yona, and Hsi-Hsien Lin 2025 F4/80, the plasma membrane antigen of mouse macrophages, an historic journey. Journal of Leukocyte Biology 117(9):qiaf126. doi:10.1093/jleuko/qiaf126 (SCI, IF=3.6) (Invited review article)
17. Celine Zheng-Gerard*, Jana Joha*, Maria Carrasquero, Kamel el Omari, Ed Lowe, Shirish Dubey, Simon J. Draper, Yu-Chi Chang, Hsi-Hsien Lin**, Alan Salama**, Kirsty McHugh**, Elena Seiradake** 2026 Structures of proteinase 3 and the CD177 receptor complex reveal major autoantibody epitope. EMBO Reports 27(6):1580-1606. doi:10.1038/s44319-026-00716-5 (SCI, IF=6.2)(**co-corresponding authors)
18. Tobias Langenhan*, ---, Hsi-Hsien Lin, ---, Nicole Scholz* 2026 Adhesion G protein-coupled receptors. Pharmacological Reviews 78:100116. doi:10.1016/j.pharmr.2026.100116 (SCI, IF=17.3)(Invited review article)
19. Hsi-Hsien Lin, Kirtana Sivasubramanian, Annabell Roberti and Siamon Gordon 2026 The Mononuclear Phagocyte System: A Dispersed Organ. Biomedical Journal (SCI, IF=4.4) (submitted)
20. Tai-Ying Chu, Kuan-Yu I, Ying-Wen Chen, Yu-Chi Chang, Martin Stacey, Elena Seiradake, Maike Bublitz-Meier and Hsi-Hsien Lin* 2026 GPR97-mediated Allosteric Activation of mPR3 Induces PAR2 Activation in Neutrophils by Unveiling Novel Tethered Agonist Peptides. (submitted)(corresponding author)
21. Ying-Wen Chen, Jaw-Lin Wang, and Hsi-Hsien Lin* 2026 Low-intensity ultrasound induces mechano-dissociation of ADGRE2/EMR2: Evidence for Adhesion GPCRs as ultrasound-responsive receptors. Biomedical Journal (SCI, IF=4.4)(in preparation)